Conserved Protein Domain Family
MFP2b

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pfam12150: MFP2b 
Cytosolic motility protein
This domain family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are found in nematodes. They complex with MSP (major sperm protein) to allow motility. Their action is quite similar to the action of bacterial actin molecules.
Statistics
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PSSM-Id: 403393
Aligned: 10 rows
Threshold Bit Score: 550.898
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003141621   8 EDTWAFGPIGSPFPDNPVHALDQPNQYVALWYKHGKPIHGRAWNNGGVLECSFPYKNAELTGAKDLGGQIQILQYK---- 83 
EFO15477       8 EDIWAFGPIGSPFPDNPVRATGQQNMYVALWYKHGKPIHGRAWNNGGVIECSFPYNKAELTGAKDLGGQIQVLQYK---- 83 
KAF8368195     8 EDTWAFQPIGAPFPENPVKVLGQQNMYVALWYKHGKPIHGRAWNNGGVVECSFPYLKAELTGAKDLGGQIQVLQYK---- 83 
XP_003139314   8 EDEWAFGPIGSPFPDNPVRVLGQPNMYVALWYKFGVPIHGRAWNNGGVLECSFPYKKAELTGTKDLGGQIQVLQYK---- 83 
1_pfamImport   1 DDIWTNQKVGTPFPTNVVKAPGETNKYVALWYRHGKPIMGRAWNDSGVMQCTFVLEDKVFTGS-DVGGVIQLLLLE---- 75 
XP_003117292   7 DDIWTFQKVGTPFPSNVAKAPGETNKYVALWYKHGKPVMGRAWNDSGVVKCTFVTDNKIYSGP-DVGGSIQLLVID---- 81 
Q94401         6 EDSWAFQPIGSPFPEAPVRVPNQNNQYVALWYKHGKPIHGRAWNNDGVVECSFPYNKAELKGKLDLGGQIQILQYK---- 81  Caenorhabditis ...
CRZ24696       6 EDTWAYNTIGSPFPDNPVRVKGQQNMYVALWYKFGKPIHGRAWNNNGNVECSFPYSKVELTGARDLGGQIQILTCSeqdp 85 
NP_495864     14 DDIWTLQKVGTPFPPNVAKAPGETNKYVALWYKHGKPVMGRAWNDSGVVKCMFVLDDKIYSGA-DVGGSIQLLILD---- 88  Caenorhabditis ...
NP_501838      8 EDTWAFQPIGAPFPPSPVKCMGEQNMYVALWYKHGKPIHGRSWNNGGVVECSFPYKEAELTTKQQLEGQIQVLQYL---- 83  Caenorhabditis ...
XP_003141621  84 -GDHNLLGFWYEWIKYKDRFE-KTEE-RQKLKCGDSLPILWKNRKAGPLMGYLD-ATELAHFSHDGKTEILQGTVLDDMY 159
EFO15477      84 -GDHLTLGFWYNWIKYKDRFE-KFEKgAELLRCGDSFPIFWNDRNEGPLLGYVDnKTEIARFSHDGKVEEVSGGALNDML 161
KAF8368195    84 -GDHRNLGYWYNWIKYSQRFD---GEhREILRCGDSIPLLWANRPQGAILGYVDnKTEIARFSHDGISEDKSGGELADMM 159
XP_003139314  84 -GDHNTLGFWYEWIKYKDRFE-KTDI-RQIVHCGDSMPILWQDRPEGALLGYLDnKTELAHFSHNGKAESLQGTPLSNMW 160
1_pfamImport  76 -PPNKKKSFHYDWVSFKKAKSlTSEGkYEMVRCDYNSPVYWAEHG---FLGCINtQLQIAHFV-DNDSKILTTNKTEDLQ 150
XP_003117292  82 -PGEKPCPFHYDWVNYKKAQSlTIEGkYEMVRCEYSASVYWPEHG---LLGCVStNRLVAYFV-DNDSQIISTKKMDDLL 156
Q94401        82 -GDYNSLGYWYEWLPLKQRHE-NNEGiREIVRCGNSVPVLAKLKDGTDKLGFLDlNTEVALFSNAGTTEKYEGGATANFM 159 Caenorhabditis ...
CRZ24696      86 vEQFKKSGFWYEWRPYKDR---ENDQlLQLVRCGQSTPVLMPTKDGNTFLGYIDmGKDVANVGYKGKNETLAGGEIQNLL 162
NP_495864     89 -HIEKSKSFHYDWVNFKKAQSlTIEGkYEMVRCEYSASMYWPEHG---LLGCVNtEKLVAHFV-DNEMQIKTTKKLEHLL 163 Caenorhabditis ...
NP_501838     84 -GDHNNQGFWYEWIKYKDRIE-KIDDkHQLVRCGDSFPIFWK-RAEGNLLGYVDnKTEEAWFSFNGKVIKQLGPQLNEMY 160 Caenorhabditis ...
XP_003141621 160 IIVRNLKggppgceckkCyvppppppkpeepppppPPGPPPP--RIMRDEWMDLRMGDPWPT-RKLVQALGKTLDTIPKE 236
EFO15477     162 IIVRELKggppncvcheC-----------------SAGPPKPvvRVTLDEWADFRYGDPWPTtGKPVQALNRALSTLSDE 224
KAF8368195   160 IIVRELKggppncecpvC-----------------AKLPPKPviRVMLNEWADFRAGDPWPA-RKMVKALDKSLDTLAGE 221
XP_003139314 161 IIVRNTKggpptcgckqCykpp---------ppkpPPGPPPP--RVMIDEWIDLRAGDPWPKdKKLIKALNKNLDTHPGE 229
1_pfamImport 151 VL---------------Ckisg---------sresADKAAALnkMTNVNDWEDFNWGSYWPInKNVMSI---PKQL---G 200
XP_003117292 157 VL---------------CkiagakeahapekdkekSSVGYSLrlSTHINDWEDFNWGSPWPTnKNVMST---PKNISPVG 218
Q94401       160 TIFRNLR-------------------------------PPPTglKVYDDLWYDLRYGDNFPS--NAVPADGRALNTETG- 205 Caenorhabditis ...
CRZ24696     163 VLFRNIK-------------------------------APPTgiKIYEDTWIDLKYRDPFPTaKNPIPGGGRKLKNDDGS 211
NP_495864    164 VL---------------Ckiagsrda--tekekekGSTGSASklLTVVNDWEDFNWGSAWPSnKNVMSI---PKNIPSAG 223 Caenorhabditis ...
NP_501838    161 IITRNCIggpphcpcavCg---------------aAPPPPKPvpRVERDEWMDIREGDPWPT-RQLVKALDKTLDTLPGV 224 Caenorhabditis ...
XP_003141621 237 DPDQYVALWYQQGEPIMGRIWkDSNGKVAAAFGWNGHEYR-DKVGSLQVLVELGHNVRGYDYSWQPFSVCGTFGEKEWLP 315
EFO15477     225 NPNQYVALWYQSGEPVMGRIW-NDGGKIAACFGWGGHEYR-KNIGSIQVLFELPEQIRGFDYAWKPFKEAAQFGAKEWIP 302
KAF8368195   222 SPDQYVALWYQAGEPVMGRVW-NEGGKIAANFSWNGKEFK-TNIGSIQILFELSEHVRGFDYGWIPYQQAATFGEKEWHP 299
XP_003139314 230 NPEQYVALWYQQGEPVMGRIW-NNNGKVAACFGWNNNEYR-EKIGSLQILVELPDFVRGYDYDWKLFSVCASFGEKEWFP 307
1_pfamImport 201 VPDQYVALWYRHGKPIMGRAW-PKNGKIDASFVDANREFTgPTVGSLQLLIALPPTTVGYDYVWMNYTLAMDYRDKDFVP 279
XP_003117292 219 F-DQFVALWYRHGKPIMGRAW-PKNGRIEASFVDSNREFTgATVGSLQLLISLPPTTVGYDYVWMAYGQAVDYRDKDYVP 296
Q94401       206 PHMQYVALWYKHGDPVFGRSYpSSAGKTMAHFGKNNQENAgPEVGSMQLLTVPEASCMGLEYKWMPLSEGKSSG---WTT 282 Caenorhabditis ...
CRZ24696     212 ETYSYVALWYKHGEPVFGRAYpDPAGKTLASFGWNGQENAgAELGSMQMIVIPQPENLGFEYKWMSYKEVKG-GAGAFKP 290
NP_495864    224 I-DQFVALWYRHGKPIMGRAW-QSNGRIEASFVDAKREFTgATVGSLQLLISLPPTTVGYDYVWMTYTQAIDYRDKDYVP 301 Caenorhabditis ...
NP_501838    225 NPDQYVALWYMQGEPVMGRVW-NEGGKVAANFSWFNNEYC-KNVGSIQLLIYLPDSVRGFDYGWIPFPEAAQFGDKAWHP 302 Caenorhabditis ...
XP_003141621 316 VYVdy-kGIISPCVITWE-GKQILGKVDIRNEKASAAFSGKENIMIGPKVQ-SQLVLCRKAR 374
EFO15477     303 VHVdhhkGNISPAVLIID-GKEILGKADIRNERATVGHGGTEKVYVGPAVH-TCVVLCRKAK 362
KAF8368195   300 VHVahhkGDISPAVIVID-GKQILGKVDIKNERACAGHGGKEVMHVAGAVH-SSVVLCRRAK 359
XP_003139314 308 VYVdr-kGIISPCVCTID-GKEILGKVDIRNEKASAAFSGKEHVMVGPSVQ-KQMVLCRKAR 366
1_pfamImport 280 VHL----SYVVPALVPVG-TKLLLGQVNMKTECATVAIDGKVTKLEGGPVK-SISVLCRREM 335
XP_003117292 297 VHL----SYICPAVVPVN-GKLILGQVNMKTECATVALDGTVTQLDGGPVK-SIFVLCRREM 352
Q94401       283 VHI----GNSAPCILKDDkGLEVLGNLDLTIEKASAGYGGKEKIMTGAAVA-KLKVLFKRRL 339 Caenorhabditis elegans
CRZ24696     291 LHV----GDCVPCVLKTAkGAELLGNLHMKMEKATAGFGGKDSAVVGPAVM-NFLVLCRNgh 347
NP_495864    302 VHL----SYICPAIVPVD-GKFFLGQVNMKTECATVALNGSVTQLDGGPVK-SIMVLCRKEM 357 Caenorhabditis elegans
NP_501838    303 VHVnnhkGDISVGVVNVAgGKQILAKVDVRNEKYGYGYQGKEHSATAKNCAdNTIVLCRKAK 364 Caenorhabditis elegans
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