Conserved Protein Domain Family
Zwilch

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pfam09817: Zwilch (490657 is an unknown moldel)
RZZ complex, subunit zwilch
The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores.
Statistics
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PSSM-Id: 490657
Aligned: 14 rows
Threshold Bit Score: 570.195
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001954734  27 PPTYLASIAG-------------------VseTGKKVVLVFkedrsg------------------saykiqHITPKKALP 69 
XP_003463521  31 PFIYEADVQVqliskgq-----pnpvksiL--GEHDVIFLV------------------------------EKAPLEKEE 73 
Q8R060        31 PFIYEADVQVqliskgq-----psllktiL--NENDSVFLV------------------------------EKVVLEKEE 73  house mouse
A6QM04        31 PFIYEADIQVqliskgq-----pnplkniL--HENETIFIV------------------------------EKVPLEKEE 73  domestic cattle
XP_001511193  31 PFTYQTDVQVrlvsagq-----qsplesfW--NGKDMVFIV------------------------------EKAPIKEEE 73 
Q95XP9        27 PVLLLDKYRVrvlpltsipfvmnhssvsqLslSSEDVLVVDfpskgtgsgag---------kaekkmifkkKIEPMEDSF 97  Caenorhabditis ...
XP_003098253  27 PVLLLNKYRIrllplsslpfvqnysnisqLslNSDDVLVIDspigatekyskks----ienskksmikeedESMEMEE-- 100
P0C664        27 PVLLLDKYRVrlvpitelplvsnysntsqLglNSEEVLVIDspiesaekqktssllnrrenkktiksekedESMDMETAE 106 Caenorhabditis ...
EGT35445      15 vksWLNKYRVrlmsvsslpfvsnysnisqLgfNSDDILVVDstvelfqkekrssi---ldnaekrsnikidDSMETEDFE 91 
Q9VA00        29 PPTYLVSMVG-------------------AaeAGKKIVLVFkedrng-------------------avarlRTTPTRAAP 70  fruit fly
XP_001954734  70 KLEgTSemdltgs---------plkddclVDAIADLSLDLQLEHsNPWKLeeefqrGVPVDQA-RGIISTEPFQQ-SEGT 138
XP_003463521  74 TSH-EE-----------------------LQSEETAISDFSAGE-NVGPL------PLSVGRA-RQFIGLYTMAH-NPNM 120
Q8R060        74 TSQvEE-----------------------LQSEETAISDLSAGE-NIRPL------ALPVGRA-RQLIGLYTMAH-NPNM 121 house mouse
A6QM04        74 PSPiEE-----------------------LQSEDTAISDLSTGE-NVGLL------ALPIGRA-RQLIGFYTMAH-NPNM 121 domestic cattle
XP_001511193  74 ANHvED-----------------------IQPEETVISELSVGE-NVGPL------GLSIGRA-RQLMALYTMSQ-NPNM 121
Q95XP9        98 EDKeNVneggplmtsf---ltleklrkgmVGDVEIIGYECETSFfDANPI------PLSDGVSlQRYIRLNCSEHfSPSI 168 Caenorhabditis ...
XP_003098253 101 -DKeNEggengplvtsf-ltleklqkgapLNDIEIVGLDCEVQFfDANPI------PFEDGVSlQRFLRLESSAHfSPAV 172
P0C664       107 GDKeNTvsetgggplvtsfltldklekdgVNDVEIVGLDCEIQFfDANPI------PFEDGISlQRFLRLESSKNfSAAV 180 Caenorhabditis ...
EGT35445      92 QDKeNNtvdggplvtsf--ltldklqknaVDDVEIVGLDCEVQFfDVNPI------PFADGISiQRYLRLESSKHfSPAV 163
Q9VA00        71 KKEgSAdldltgs---------plkddclVDAIADLSIDLQLDHsNPWKLeeeyqrGIPVDKA-RSIVCSEFLQL-AEGL 139 fruit fly
XP_001954734 139 GSV------------WFLCDGTDLGQTQLLQYEFNKSH-----FSRGILSYHg--VVPAYMVTSQFLVKQHSMVGGGAPM 199
XP_003463521 121 THLkverpvtalpplWVRCDGSDPEATCWLGAELVTAGdsvtgVVLYAVSCK---ADKNYFLSLENLKNVHKTRHHLSTA 197
Q8R060       122 THLkikqpvtalpplWVRCDGSDPEGTCWLGAELITTNdiiagVILYVLTCK---ADKNYSEDLENLKTSHKKRHHVSAV 198 house mouse
A6QM04       122 THLkinrpvtalpplWVRCDGSDPEGISWLGAELISTSsnitgIVLYMVTCK---VDKNYSVNLEDLKKSHKKRHHLSTL 198 domestic cattle
XP_001511193 122 THLeisrpvpvlpplWVRCDGSDPEGTCWLGAEPLKTKssitgIMFHIVTSTgpvADKSCLVKLEDLKKRHKKRHHSSTV 201
Q95XP9       169 STLp----------vWISTTSSKFPSICWLAAGRTNRN----------VQFAa--ATR----VLGHFNNENSERVVKQLN 222 Caenorhabditis ...
XP_003098253 173 DKLp----------iWISTISQNIPSVCWIASGRTQKN----------IQFSg--VTR----VIGHF-NEINQKLIKQLN 225
P0C664       181 DKLp----------iWISTIGHHFPSVCWLAAGRTNKN----------VQVSg--ATR----ILGYF-NENSQKLVKQLN 233 Caenorhabditis ...
EGT35445     164 DKLp----------vWISTISSHFPSVCWLAAGRTTKN----------IQVSg--VTR----VLGYF-NENSQKIVKQMN 216
Q9VA00       140 GSV------------WFLCDGSDLGQTQLLQYEFNPTH-----FSRGILSYQg--VRPAYLVTSQALVRHH----GKTPD 196 fruit fly
XP_001954734 200 ET---SIENSYQVNP---------------QMTIRCSWTTNas------------lPLLVNLHDCEVVLNHTFRAG---- 245
XP_003463521 198 TAkgfAQYELFKSSVlddva-----aqshtAITLDLSWSPV---------------NEMLEVPPLSSAATLNIKVEs--- 254
Q8R060       199 TArgfAQYELFKSDDlddtv-----apsqtTVTLDLSWSPV---------------DEMLQTPPLSSTAALNIRVQs--- 255 house mouse
A6QM04       199 TAsgfARYELFKSTAlddtv-----aasqtTITLDISWSPV---------------DEILQTPPLSSTATLNIKVEs--- 255 domestic cattle
XP_001511193 202 ATrgfARYELFRSTAlddti-----salesSITLDVSWSPV---------------DEVLQIPPLTSAATLNIKVEs--- 258
Q95XP9       223 QAcgtSQLNKYRAVYeeirkiatenrpapgEVTIDVRWSTK---------------STLVLLEHPDNAADCTIKIDlgwg 287 Caenorhabditis ...
XP_003098253 226 EAagaAQVNRYRAVYdgirkiatptrespgEVIIDMRWNTK---------------SSLVLLEQPDNAADCIIKIDlgwr 290
P0C664       234 EAcgaAQVNRYRAVYdvirkiatptreapgEVIIDMRWNTK---------------SSLVLLEQPDNAADCTIKIDlgwg 298 Caenorhabditis ...
EGT35445     217 EAcgaAQVNRYRAVYegirkiatptrdapgEVIVDMRWNTKvwiklkvvikcfliqSSLVLLEQPDNAADCTIKIDlgwr 296
Q9VA00       197 ET---LIENSYQVNP---------------HMRLRCSWTSSaa------------lPLLVNLNDCDVALNHTFRVG---- 242 fruit fly
XP_001954734 246 -ECTPLTQDFMNQLRILVYIREDIVSYHKDIQHGKMRDPTYRCGTGIdMDELrESINKTMTDvSGFI--DPYSNGLAEFD 322
XP_003463521 255 gEPRGCLTHLHRELKFLLVLADGLRTGVTEWLEPLEAKSAVDLVQEF-LNEL-NKLDGFGDS-TKKD--TEAVKHDAAAV 329
Q8R060       256 gESRGCLSHLHRELKFLLVLADGIRTGVTEWLEPLETKSALEFVQEF-LNDL-NKLDEFDDS-TKKDkqKEAVNHDAAAV 332 house mouse
A6QM04       256 gEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEF-LNEL-SKLNEFGDS-TKKD--TEIVKHDAAAV 330 domestic cattle
XP_001511193 259 gDPRSLLYHLHRELKFLLVLAGGLKTGITEWPEPLEAKPAVELVQEL-LTDLkNKLDGFVTS-GKKE--AEEVKCDTAAV 334
Q95XP9       288 dKRFFVDDEIFEQLFFVLNLADVLANPDNEVIFPMAPPAN--------FDDLvQEMDALVEAsSRED------------- 346 Caenorhabditis ...
XP_003098253 291 dNRFFIDESIFEQLFFVLNLADVLANPEKEVIFPMEYVK---------FGDLvKEMDDIVEAcSHED------------- 348
P0C664       299 dNRFFIDETIFEQLFFVLNLADVLANPEKEVVFRSESDK---------FDDLvQEMKQLVEAcSHED------------- 356 Caenorhabditis ...
EGT35445     297 dKRFFIDEAIFEQLFFVLNLADVLANPEKEVVFPSESAK---------FDDLvQDMNELVDScSQED------------- 354
Q9VA00       243 -DCGPLTQDFMNQLRILVYIREDIVSYHTDVKQGVSRDPTYRCGSGIdMDELrESINQTMTDvSGLI--GRYSISNAEFD 319 fruit fly
XP_001954734 323 IEEVvqRAKVRRLTDLTDKLWELLKCC-ASYKDLKVAFSLLFQCAARCNIVN--TPTNKNRLAEIITELSNRRLAMPCLS 399
XP_003463521 330 DRAV--LITVRDDLDFVEQLWCKMSSSvVSYQDLVKCLMLVMQSLQQDDIQPwlHSESNSLLSKLIHQSYHGAMDAVPLS 407
Q8R060       333 VRSM--LLTVRGDLDFAEQLWCRMSSSvVSYQDLVKCFTLILQSLQRGDIQPwlHSGSNSLLSKLIHQSYHGAMDSVPLS 410 house mouse
A6QM04       331 DGSIecLLTVRGDLDFAEQLWCKMSSSvISYQDLVKCFSLVIQSLQRGAIQPwlHSGSNSLLSKLIHQSYYGTMDTVSLS 410 domestic cattle
XP_001511193 335 DESIkwLFMERGDLDFAEQLWCKMRKSiASYQDLVKCFTLVIQALKCGDIQPwlHSGSSSLLGKLIQQSYHGTMDVVSLS 414
Q95XP9       347 --NVfvSNENFRGGDITDKVWNIVRKC-NDVKQVTLLFRNFLQALAYGKIKShaQERNKSHLASLIRISKSSEFKIPVLE 423 Caenorhabditis ...
XP_003098253 349 --NVfaSNE--KNEEVTDKVWNIVRKC-GDIKHATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFRMPILE 423
P0C664       357 --NVfaSNE--KSEQVTDKVWNIVRKC-SDVKQATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFRMPILE 431 Caenorhabditis ...
EGT35445     355 --NVfvSNE--KSEEVTDKVWNIVRKC-GDVKHATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFRMPILE 429
Q9VA00       320 IEDVvqRAKVRQLTDLTDKLWELLKCC-HSYKDLKIAFSMLFQCAARCNIVN--TPTNKNRLAKIITELANRRLAMPCLS 396 fruit fly
XP_001954734 400 GAEPLELLLEIGLEKVLKDYEFIYSESKLCSTHLLRDTNetandegspqnvpqvrkslhnavrgdpaaga-gmrktllhh 478
XP_003463521 408 GTVPLQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFI----------------------------------------- 446
Q8R060       411 GTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFI----------------------------------------- 449 house mouse
A6QM04       411 GTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFI----------------------------------------- 449 domestic cattle
XP_001511193 415 GSTPIQMLLEIGLDKIKKDYINCFIGQELASLNHLEYFI----------------------------------------- 453
Q95XP9       424 RLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILqtcendlp--------------------------------- 470 Caenorhabditis ...
XP_003098253 424 RLSTIEMMMEIGVESLRGRIINKFSSTLQFPADELTFILktcenelt--------------------------------- 470
P0C664       432 RLSTIEMMMEIGVESLRGRIINKFSDTLQFPSDELTFILktcendls--------------------------------- 478 Caenorhabditis ...
EGT35445     430 RLSTIEMMMEIGVESLRGRIINKFSSTLQFPTDELSFILktcendls--------------------------------- 476
Q9VA00       397 GAEPLELLLEIGLEKLYKDYEFIYTESKMCSTNLLKDDSsgasmddgspqnlpqlrkslhnavrgdptpgagmrktllhh 476 fruit fly
XP_001954734 479 nasaktgnakygkvdddsgfkNSHFDEQESLERVSKLFQIHCTL---EHLLMIHINLNLPNVYSDVCSELLKKAPKIVDA 555
XP_003463521 447 ---------------------SPLVEIQEQVHRVQKLHHILELSv--SCMLFLKPQHEFLFSLTQSCIKYYKQNPLDEQH 503
Q8R060       450 ---------------------SPSVSTQEQVCRVQKLHHILEILv--ICMLFIKPQHELLFSLTQSCIKYYKQNPLDEQH 506 house mouse
A6QM04       450 ---------------------SPSVDTQEQVHRVQKLHHILEIVv--SCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQH 506 domestic cattle
XP_001511193 454 ---------------------TSAVDIQEQVHRVQKLHHMLEIVi--SCTVLLKLKHEILFPLTQSCIKYYQQNPLNEQH 510
Q95XP9       471 --------------agngamnSAAISLLPITMALATANRIYELLnekDHVILPDLTRRILQKYTASMIEKSRRGETETEY 536 Caenorhabditis ...
XP_003098253 471 --------------tgegalnSSVVSLLPITMALATVNQIFGLLnekDYVLLPELARRVLTKFTSGMIEKAKRGETETDY 536
P0C664       479 --------------tlegtlhSSVVSLLPITMAMATIHQIFGFLnvkDLVVLPDLARRVLTKYTTGMVEKAKRGETETDY 544 Caenorhabditis ...
EGT35445     477 --------------tvedalnASVVSLLPIAMALATVSQIFGLLnekDHVILPDLARRVLTKFTSGMVEKAKKGETETEY 542
Q9VA00       477 hgavnsrstkyagsdddagfkNSHFDEHESTERISKLFQIHCTL---EHLLMMHIHLNLANVYNDVCSELLKKPPKLVES 553 fruit fly
XP_001954734 556 IDEnvNDVMDIQLSALYvrehlEGKEPYSRHISMRSh---nKFREIKTTFYFNS-------------------------- 606
XP_003463521 504 VFQ--LPVRPACVKSFY-----QSEKPQKWKVEING-----GQKKVKTVWQLSD-------------------------- 545
Q8R060       507 IFQ--LPVRPAAVKNLY-----QSEKPQKWRVELSN-----SQKRVKTVWQLSD-------------------------- 548 house mouse
A6QM04       507 IFQ--LPVRPTAVKDLY-----QNEKPQKWRVEINS-----GQKKVKTVWQLSD-------------------------- 548 domestic cattle
XP_001511193 511 LFQ--LPIRPTAIKKFY-----QSESPQTWRVEVSSg---pGQ-EVKTLWQLSD-------------------------- 553
Q95XP9       537 TFEttLPLLRMYKEGFM-----SKR-PCIWTCENSNtvganVQARVLTSLELQPslehinrlvnd-----srpvwtatee 605 Caenorhabditis ...
XP_003098253 537 TFEttLPLLRMSKEKFM-----DKR-PRIWTCENMStvgahCQTRIMTSLELESsmehvsrivnagrpireiveteetqr 610
P0C664       545 VFEttLPLLRMNKEAFM-----HKR-PRIWTCENTNtvganVQTRAMTTLELEPslehvcrlvnas---rpvrpidednr 615 Caenorhabditis ...
EGT35445     543 TFEttLPLLRMSKENFM-----DKR-PRIWTCENTNtvganVQTRIMTALELESsvehvsrivnas---rpvremkeene 613
Q9VA00       554 IDDqlSDVMDIRLSAHYvrdhlDGKDPYSRHITMRSh---nKFRELKTTFYFNS-------------------------- 604 fruit fly
XP_001954734 607 ENICPPELAKCFQCD-DKEMVKER 629
XP_003463521 546 SSPVEHLNYPKPDFS-DLTLNGSL 568
Q8R060       549 SSPVDHSSFHRPEFP-ELTLNGSL 571 house mouse
A6QM04       549 SPPIDHLNFHRPDFS-ELTLSGSL 571 domestic cattle
XP_001511193 554 NPPVEHLSFSKQDLS-ESTFNSNI 576
Q95XP9       606 KPAMIK------DLNaDYTVVHTI 623 Caenorhabditis elegans
XP_003098253 611 KPTIE-------ELNaDYTVSHTv 627
P0C664       616 KPTEE-------ERNaDYTVSHTI 632 Caenorhabditis briggsae
EGT35445     614 KPTAE-------ELDaDYTVSHTv 630
Q9VA00       605 ENICPPNLAQCFQCD-DKEMVKER 627 fruit fly
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