Conserved Protein Domain Family
RNase_H2-Ydr279

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pfam09468: RNase_H2-Ydr279 (490396 is an unknown moldel)
Ydr279p protein family (RNase H2 complex component)
RNases H are enzymes that specifically hydrolyze RNA when annealed to a complementary DNA and are present in all living organisms. In yeast RNase H2 is composed of a complex of three proteins (Rnh2Ap, Ydr279p and Ylr154p), this family represents the homologs of Ydr279p. It is not known whether non yeast proteins in this family fulfil the same function.
Statistics
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PSSM-Id: 490396
Aligned: 82 rows
Threshold Bit Score: 60.861
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003664233 130 FLLLPALCGAptitTTtttttgrdqerqgqneqeeqsqqrqqKKRLFLSLDDHL--DATADP------------------ 189
EGN99664     106 FLIIQILLASqpndGS---------------------------PGNFRPIDDIF--EEAAVKlaktpiestp--avqdas 154
Q5KB28        81 FIVIPLILALvpngP----------------------------PPPFQPLHDLLsaASTSTSfalplpftsgtkgkspnr 132 Cryptococcus ne...
XP_009270395  83 FIVASLLLSVpdhaR-----------------------------STYSRFEDIT--DTLRNAh----------------- 114
XP_714251    118 YLLISLFSNInqqkSQqqsqqss-------------lssenlFNDNFKSLEDLK--DQLLN------------------- 163
XP_036667880 123 YLLITIFEKHgd------------------------------kfSRFHTLDDIR--DRLSS------------------- 151
XP_001526203 101 YLLISIFHTHqekfR-----------------------------NTFKTIDDIR--DSLES------------------- 130
XP_007374371  96 YLLISILSSQke--------------------------------dRFITVDDFM--DRVAw------------------- 122
XP_001384175 106 WLLIAIFYKHnq------------------------------fsKNYISAEDVM--DKIAG------------------- 134
XP_002619377  98 YFVISVMWHKkelyG-----------------------------GRYHAMDDIL--DNFSA------------------- 127
XP_003664233 190 ----SGHLADLL---As-CPATRRRVEARLAAVCDAV--------------------P--AG-D------------ETMY 226
EGN99664     155 aipsQRDIMQLAsldC---------IKAAMSRICDVK--------------------EitTE--------------ITVY 191
Q5KB28       133 segvNEDIERLLtlkN---------VKRAFKACCEKK--------------------VisTApPspdpssspqpptQSFY 183 Cryptococcus ne...
XP_009270395 115 ---tDCDILPLLhtnA---------AKAGLERCCESK--------------------E--LAaD------------EMVY 148
XP_714251    164 ------EYREDTnnnDwvLEIPDQLYHQSLINLCDVI--------------------T--ENiD------------ESFY 203
XP_036667880 152 ----------LElghDwvYDIPRVVFLKSLANICESIieggggngdgngeegnrslsDaiEDaG------------DRFF 209
XP_001526203 131 -----------LgeyTwvYDVPERIYLLSLDSICESI--------------------I--EGnQ------------ERFY 165
XP_007374371 123 -----------------sHNLPESVISNALVQICDEL--------------------D--QG-D------------AKFY 150
XP_001384175 135 -------VFSGNgndQwvHKIPYFLYEQSLAKISESI--------------------D--ES-G------------DSFF 172
XP_002619377 128 ----------YVkpqKslQDIRPHLVK-SIESLCQVV--------------------E--EG-G------------EPFY 161
XP_003664233 227 RVSEAKLARELLAKAKRIVgEEaskLPASMEERFVRRELEPPVLGVRIArgtgsgsesgsgsgtatpassssegesqess 306
EGN99664     192 RFSPDNLLAYLRSKVERLSkPEileKSRSLIRSMAKDGL----------------------------------------- 230
Q5KB28       184 RPSQDLIIQHLKRKAGFFAgPEefeKFDHLVRGLGRDGL----------------------------------------- 222 Cryptococcus ne...
XP_009270395 149 KLSEPRYLGYLDAKIARC-------LSTVVAQRDIKC-------VE---------------------------------- 180
XP_714251    204 RFDLSKILHWLNEKVLALQkYI------LTNDNSILTKLKLELNP----------------------------------- 242
XP_036667880 210 KYSETKSLEWINSKIVALQqWIlhsDDDKRTTNSIMSKIKKGLHDPTRN------------------------------- 258
XP_001526203 166 KYSVNKAMDWVNGKVIALSnFI-----FEEKGNSIMRRIQLELNDP---------------------------------- 206
XP_007374371 151 KFSLDKSIQFVNEKITKLVeFF------TNEKNTVIEKVRAELND----------------------------------- 189
XP_001384175 173 KFSLKKSFEFVEKKVERLQtYF------ASGDNSVLVTIKGKLTDT---------------------------------- 212
XP_002619377 162 KFSTEKAMKFVSTKIDSLTdLL-----HSSPDYALTGFIRNKLN------------------------------------ 200
XP_003664233 307 vssassaetaassgseestktttstaatsvaadsdegDGVATSATGASDEVVRLQRLRVAFSFICSRYVS-PAIAAMLN 384
EGN99664     231 -------------------------------------------MEDGREDLLELGRVKAACDLI-SQYIP-PSIYQTLL 264
Q5KB28       223 ------------------------------------------LEKDIDEELLSSARLRAACDHL-AQWLP-GPVLSKLV 257 Cryptococcus neo...
XP_009270395 181 ---------------------------------------PPTHHLLTPELTLQSYKRNMVECVLYN--VP-YSLHTIVR 217
XP_714251    243 ----------------------------------------SMSNNNIEDQLLNDLGLLYSIDYIFNSYLD-DGVNSFLR 280
XP_036667880 259 -------------------------------------EDTSTNQEEEQNQLMDQMAMIYAIDYVCDSYIP--DTKSKII 298
XP_001526203 207 ----------------------------------------TSIEGHINEEVLQNTVMCCAIDYVCFSYLC-KGVREVLV 244
XP_007374371 190 ----------------------------------------PTSTEVVSQQLVSELTLQYAIDYVCGSYIAePTFKQDLI 228
XP_001384175 213 ----------------------------------------TLAEHTIPEPILKSMVLRYAVDYVCDSYIG-SEFKKEFI 250
XP_002619377 201 ------------------------------------------AYEEAPDEIFQLQIKKYAVEFIFGSYLT-QEIKHDFM 236
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