Conserved Protein Domain Family
RNase_H2-Ydr279

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pfam09468: RNase_H2-Ydr279 
Ydr279p protein family (RNase H2 complex component)
RNases H are enzymes that specifically hydrolyze RNA when annealed to a complementary DNA and are present in all living organisms. In yeast RNase H2 is composed of a complex of three proteins (Rnh2Ap, Ydr279p and Ylr154p), this family represents the homologs of Ydr279p. It is not known whether non yeast proteins in this family fulfil the same function.
Statistics
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Aligned: 91 rows
Threshold Bit Score: 41.9858
Threshold Setting Gi: 74683166
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:MYCTH_2306825   130 FLLLPALCGaptitTTtttttgrdqerqgqneqeeqsqqrqqKKRLFLSLDDHLDATADP---SGHLADLL---As-CPA 202 Thermoth...
CCE86857            101 YFLISVMHGedn------------------------------faKRFITLEDIIDSLGS----------KYdgqEwvNSV 140 Milleroz...
XP_001486062        100 FIFITIMAEsdt------------------------------fsKRYISYQDILDTIGSq-------------nPwiNDL 136 Meyerozy...
Q6BWG7              101 YYLMSIMYNnds------------------------------faKRFITFEDFSDTISS----------LFeynAwvGAV 140 Debaryom...
EEQ36413             98 YFVISVMWHkkelyG-----------------------------GRYHAMDDILDNFSA----------YVkpqKslQDI 138 Clavispo...
WGS:AATM:SJAG_00400  74 PFVLPVLQEltwnrQN--------------------------EPVRYVVLEDIKDSFAARgpaYALVLQILpn------- 120 Schizosa...
EPY53527             75 IFMLPVLQEltwnrRS--------------------------EPCRFISFDDILDHFNAQgahYSRVSRVLes------- 121 Schizosa...
O94627               75 ALVLPIIQEltwsrRK--------------------------EPNRYVSFEDFIEHFDNMgphYPRVSEVLsp------- 121 Schizosa...
EOQ98745             83 FIVASLLLSvpdhaR-----------------------------STYSRFEDITDTLRNAh-tDCDILPLLhtnA----- 127 Wallemia...
XP_011274091        104 YILITYFILqleqgK---------------------------EFRRYQSLEDITDVLEES---IPIILQL---------- 143 Wickerha...
jgi:MYCTH_2306825   203 TRRRVEARLAAVCDAVP--AG-DETMYRVSEAKLARELLAKAKRIVgEEAskLPASMEERFVRRELEPPVLGVriargtg 279 Thermoth...
CCE86857            141 PFAIYIRALGMICEKIE--EN-DETFYKYSKDKAFTFLQNKIDEVTkYL-----LSKPDVALNKKIMSELLTS------- 205 Milleroz...
XP_001486062        137 SDTLIINCLGKICETVV--EN-QETFYKYSSEKTAEMLSEKVNKLEkLI------SNSSFVINDTIRQILHDP------- 200 Meyerozy...
Q6BWG7              141 PMTMYKSALSEICETIE--EN-DEIFYKYSNAKVIEYLHRKVSQLLaYL-----SSQSDLSIILKIKQELYRP------- 205 Debaryom...
EEQ36413            139 RPHLVK-SIESLCQVVE--EG-GEPFYKFSTEKAMKFVSTKIDSLTdLL-----HSSPDYALTGFIRNKLN--------- 200 Clavispo...
WGS:AATM:SJAG_00400 121 ---aFLRALNVACSKKEssNGmPET-YQLSKKQVLTYLQQKIQVAVdNLPpsICSHLLQQLTPVEYGKNV---------- 186 Schizosa...
EPY53527            122 ---kLENTVHRICKVNAaiGSlPRT-YQLDKDAVIQMLHRKLRVAEeNLPtsIIRELNHQLAPLDLDSPI---------- 187 Schizosa...
O94627              122 ---nLLNTLHRICKVNEpvGSlPKT-FQLDESSVVKILLRKAKVAQeNLPpsIVTELKKQLAPLDLRTPL---------- 187 Schizosa...
EOQ98745            128 ----AKAGLERCCESKE--LAaDEMVYKLSEPRYLGYLDAKIARC-------LSTVVAQRDIKC-------VE------- 180 Wallemia...
XP_011274091        144 PGSLLNTSLENICDSIN--EN-DEKFYKFSEEKTINYLKTKSELISqNF---------PKSIESTIVSPLLYP------- 204 Wickerha...
jgi:MYCTH_2306825   280 sgsesgsgsgtatpassssegesqessvssassaetaassgseestktttstaatsvaadsdegdgVATSATGASDEVVR 359 Thermoth...
CCE86857            206 -------------------------------------------------------------------SIDATKIPSEVLQ 218 Milleroz...
XP_001486062        201 -------------------------------------------------------------------SSANLEIPSDIYN 213 Meyerozy...
Q6BWG7              206 ------------------------------------------------------------------ISEGSNDIPSDILQ 219 Debaryom...
EEQ36413            201 ---------------------------------------------------------------------AYEEAPDEIFQ 211 Clavispo...
WGS:AATM:SJAG_00400 187 --------------------------------------------------------------------------PDDIVA 192 Schizosa...
EPY53527            188 --------------------------------------------------------------------------PGDMFQ 193 Schizosa...
O94627              188 --------------------------------------------------------------------------PQDLLE 193 Schizosa...
EOQ98745            181 ------------------------------------------------------------------PPTHHLLTPELTLQ 194 Wallemia...
XP_011274091        205 -------------------------------------------------------------------ANIDEKIPEDIKK 217 Wickerha...
jgi:MYCTH_2306825   360 LQRLRVAFSFICSRYVSPAIAAMLN 384 Thermothelomyces thermophilus ATCC 42464
CCE86857            219 ESTTKHSIDLICGSYVPVHVKQELC 243 Millerozyma farinosa CBS 7064
XP_001486062        214 LAVMQHCIDLVC-CYIPFKVRELVI 237 Meyerozyma guilliermondii ATCC 6260
Q6BWG7              220 LSIIRHSIDLICGSYTPIEIRNQVM 244 Debaryomyces hansenii
EEQ36413            212 LQIKKYAVEFIFGSYLTQEIKHDFM 236 Clavispora lusitaniae ATCC 42720
WGS:AATM:SJAG_00400 193 LAKRRCAIGFVCDGIIM-PFASELT 216 Schizosaccharomyces japonicus yFS275
EPY53527            194 LACKEHAAYLVFEDFSK-DWFNQIA 217 Schizosaccharomyces cryophilus OY26
O94627              194 LSCKWHAASLVCEDLQP-EWYNKLA 217 Schizosaccharomyces pombe 972h-
EOQ98745            195 SYKRNMVECVLYN--VPYSLHTIVR 217 Wallemia ichthyophaga EXF-994
XP_011274091        218 LALIKYSIHLI-SSYLHPKTESRLn 241 Wickerhamomyces ciferrii
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