Conserved Protein Domain Family
BUD22

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pfam09073: BUD22 (490104 is an unknown moldel)
BUD22
BUD22 has been shown in yeast to be a nuclear protein involved in bud-site selection. It plays a role in positioning the proximal bud pole signal. More recently it has been shown to be involved in ribosome biogenesis.
Statistics
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PSSM-Id: 490104
Aligned: 63 rows
Threshold Bit Score: 59.4645
Created: 21-Aug-2024
Updated: 23-Aug-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS97129       52 YtDVLRMLKKARGFERQRLVRRIaeeKTQSKtgkkskgkkakksaadnvdgdgdgdtDQRSERLQRLE------------ 119 
EKD01031      688 RtKLHQLFKQAKREESQRLIKKI---KFLSK--------------------------KGSSSEADELD------------ 726 
Q5KCW5         93 K-SLHPVFKQAKTFETRRLIKKI---KFLRN--------------------------KDVKDETADLE------------ 130  Cryptococcus ...
XP_001835950   34 Q-EVYQACKKAKTFETQKLVKKL---KGLRKd-------------------------SSDTNAVQEHE------------ 72  
2_pfamImport    5 R-EVRKAAKKAKTFETQKLLKKL---KDLRRk-------------------------AEKPNEITDAE------------ 43  
EMD39958       37 R-EVRKAAKKAKIFEVQKLVKRL---KSLRAk-------------------------DPAADAIAGLE------------ 75  
XP_007399343   24 K-ELKKAAKKAKDFEIRKLVKRL---KGLRVk-------------------------KPAPPELRDLE------------ 62  
NP_492224     116 V-ALRATCLTAKNQLMSRIVRQK---KQLE---------------------------SKKSQKVDGKSkeerdrkiarlv 164 
XP_006959516   44 NvDLRRATKDAKTSERQRLQKKI---TQAEKksa--------------------kgeEIDRVQLEETQ------------ 88  
XP_009269864  122 HvDLRRAVKDARVSEHKRLQKKL---TQLEKmss--------------------kgeKVDSQQQEEAQ------------ 166 
ERS97129      120 REVEVLKTLDYEVTAR-VHLANAMLRTRGLAEAPgplgahlqLASEVLS-----------QRTKAYRTDDIHNVTSALYN 187 
EKD01031      727 TQLKLLGAVDLHILSA-NHLKLKLRKHYLLKKDG--------MPSDVESviggg--qtvkASGSNATPEVIAKVENRLCS 795 
Q5KCW5        131 SQLKIIHDIQLQPLAK-SHLLVKLRKHPLFKQTP--------LPSEISSllsppsattasFAGTSATPALINKAENRLCS 201  Cryptococcus ...
XP_001835950   73 AQLTALKELDIHSIAR-TAFKTKVLKDRTLRDSEl-------IMSGLEKeitnti-------ipspasTPLGKVQSRLLS 137 
2_pfamImport   44 AQLDAIKHITLDVIAD-TALRTKMNKDHILSTNEd-------LQHALSMellpspi------asaaagSHLAKVQSRLLS 109 
EMD39958       76 AELEALKHVDHEPVAK-SALKSKLKKDRILASNTh-------AQAAIAAelttdll------tpsaagTPAARVESRLLS 141 
XP_007399343   63 EQLVLLKEIDHKTIAS-MALKTKLKKDKQLSENEn-------LVAAISQelscli-------vpaqpgSNLAKVQGRLLS 127 
NP_492224     165 EEILGLKTFDKDSVAKfAALNTKSLAELKINGKT----------------------------------EVAERLMYKLVC 210 
XP_006959516   89 NQLNETKDYDGLIAAQ-HTFFSKLSKH-----SSgayktreeVILALKNlnfdfpni------aqasnapeGKLAARFMS 156 
XP_009269864  167 NQLIETKEYDGLPAAQ-HTFFSKLSKH-----NQgafksreeVIHALNKlsfnwpai------slpsnapqGKVAARFMS 234 
ERS97129      188 RPFVRDAVAKAVA-GM---CQLLGLPP----------PEKSVSRVRKQRKEEDEEED------------EEEEKDSVDdd 241 
EKD01031      796 AKNVADGVKGIVSwCLaepGSSLNLDKmkekknkknaKPESDEDSDDASEGDDEREDdva-------nvVGELDSDDEvv 868 
Q5KCW5        202 AKIVAERMKNVVSwTVcegGAKLVIEKkpatisagkgGSKKAAESTDEEDDEQEEGEeanv-----gdiSRSMVNGSD-- 274  Cryptococcus ...
XP_001835950  138 SKHLSSQISISID-GL---KVILDPEYapqqkkqrttSAEPPNAASIASSKRTRTQRhskegslqaadvGSESEDSED-- 211 
2_pfamImport  110 SKVLASEISIVIG-GI---KATINPAFaaaqd-aaseGESDADVPAVPRKTKRVSADkst-------------------- 164 
EMD39958      142 SKTLAAEVHAVVD-SL---KEVIVPTKkakke-aqteEKEGDGEDDDDNADVERPAKa---------------------- 194 
XP_007399343  128 HKVIAAEVHTIVE-DV---RTTVFPELkltavteasdGELHEDVPLRPTKKVKMVSAgp---------eKTDEGDSDD-- 192 
NP_492224     211 QSIIVEKIQSIREkYTewnKTAAFFMQrlgqq-yankPEKKSKKSTEKKELNIENLEd----------lNNEDEDSEN-- 277 
XP_006959516  157 IEQVSKVAKAGVD-SV---SSILGDSA----------AEKQKQSEQLEDSKESAEDDevd-------dkLESNTTSDKpa 215 
XP_009269864  235 IEQISSVAKSAVD-SV---VSILGDGA-------------------------KKENEvnvqa--eqvpaDDKQIKNDKtl 283 
ERS97129      242 trrhtqantpkdktIAWRSESSEDEEADDDNDEDTEDnmeyneaddkaie------------------------------ 291 
EKD01031      869 ve--------ekaaDAAGWESGDLGGEGSDEDDEEGEdgwesgsvggee------------------------------- 909 
Q5KCW5        275 ---------------SEEDSDDERVLQDRAAD----Aagwes-------------------------------------- 297  Cryptococcus ...
XP_001835950  212 ------------------DDLRDEEGADDESEDGDGAdgwesgsisgdedyvgrl-----------------------ap 250 
2_pfamImport  165 -----------hghSMSVPEKNEEDGGNAEEDENILDdgwesgtisggdqas---------------------------- 205 
EMD39958      195 --------------KKRESAAKLHVEAADDSDAEVDDagwesgsihgenededqpadd----------------gwesgs 244 
XP_007399343  193 -------------------ESSLNNRVTISDEEEVADdgwdsgtvhgesdseeeed---------------------nka 232 
NP_492224     278 -------------------EKEEEIEENEEDydqsd-------------------------------------------- 294 
XP_006959516  216 p-----------reQKATPTIDSSALIAKLTGALGGVvrddededndaqsdagsdisaplsgytsgeasneedalkdwpe 284 
XP_009269864  284 qp--------ptqiKKERPATDNSALIAKLTNSLGGTvrddddeeeedqeadsdaplsgytsgeasddalqnwpdpdads 355 
ERS97129      292 ---relakfesrlgsDEDDDEDesdendseddglgsgsdddsdgdldddavvaklrakyaaavakglwqdddrdrddfsg 368 
EKD01031      910 ----gtgedawiasaSDSDAPDyaalanl--------------------------------------------------- 934 
Q5KCW5        298 ----------gsvsgFDSEGGE---------------------------------------------------------- 309  Cryptococcus ...
XP_001835950  251 sspvgsdeensgseqDDDDDSD---------------------------------------------------------- 272 
2_pfamImport  206 -edewesgsvddvhhGTKEDGD---------------------------------------------------------- 226 
EMD39958      245 vdggrpggtallgdeSSDEDEDe--------------------------------------------------------- 267 
XP_007399343  233 edngvasevktkdgeSDDEDTvsrs------------------------------------------------------- 257 
NP_492224     295 ----------iemldSDEEEAGee-------------------------------------------------------- 308 
XP_006959516  285 peeevdesneeeeeeSDDEDEG---------------------------------------------------------- 306 
XP_009269864  356 dgdddnddinnddinNDDDDAD---------------------------------------------------------- 377 
ERS97129      369 edsdgadfeeeqdDEQGEGGEEEEEFGGFSDDGEVDDESESESDED-----------------LRPRKRKATSATTFDgT 431 
EKD01031      935 -------kggageDWSSGSEGDSDAGSASDSSSGSSVAVERPPAKKvkaevskkaekpvkaekKPEKKAAKAEKPKPDgT 1007
Q5KCW5        310 ----------------VDIASESESESDNSDAIAVPSAKRAKTAVPplppk--------skplKSEKADKPPKSAKDLtS 365  Cryptococcus ...
XP_001835950  273 ----------------------------------------PESDEDtkpmkkanaggstssktPKVASGASSKPAKIN-E 311 
2_pfamImport  227 ------------------------------------YSSGSEGNLAapss----------pplPNESKPHQGKAKTVGsQ 260 
EMD39958      268 ----------------------------------dPSASDSEVQPPprkv----------akpSTATHDAKGKSKATSaE 303 
XP_007399343  258 ------------------------------------------------------------kqpPRKTPPPRASTSKKG-E 276 
NP_492224     309 --------------------------------------------------------------aAKNRRNLLLGLIGVQ-E 325 
XP_006959516  307 -------------------------------------------------------------------------------G 307 
XP_009269864  378 -----------------------------------------------------------------------------N-G 379 
ERS97129      432 SHFLPSL-MG-GYVSdGGDDa-----dGVADDE--------EAAArmlggpRKNRRGQRARQAIWEK-------KYKQLA 489 
EKD01031     1008 SMFLPSL-AA-GFTA-GDSD-------SDPDMDydpdgvigNKAAp-----RKNRRGQRARQAIWEK-------KYGKNA 1065
Q5KCW5        366 SIFLPSL-SV-GFTR-GDDDd------SDPDLDddpngvagKQPVv-----RKNRRGQRARQAIWEK-------KYGKNA 424  Cryptococcus ...
XP_001835950  312 STFLPSL-QV-AYIS-GSDDsd----aEAEVAEp-----------------RKNRRGQRARRAIWEK-------KYGRNA 360 
2_pfamImport  261 STFLPSL-AV-GFAR-GDSDsdw-sesEAKDADg----------------iKKNRRGQRARRAIWEK-------KFGKNA 313 
EMD39958      304 STFLPSL-SV-GFTR-GDSDasdlsdsEAKAADn----------------gRKNRRGQRARRAIWEK-------KYGRNA 357 
XP_007399343  277 STFFPSL-AV-GFTR-GDSDasdlsdaEVARAEgg---------------aRKNRRGQRARRAIWEK-------KYGKNA 331 
NP_492224     326 DKNRPSL--------------------APKKRKlveeedeeVETV----------KNQKKMKQIFEKelkskevKNPKKS 375 
XP_006959516  308 NTILDSLnAGvGYIS-GSDD-------DISDAEe------kVAP-------RKNRMGQRARRAILEK-------KYGRGA 359 
XP_009269864  380 NALLNSLnTGvGYIS-GGSD-------DISDAEe------kVAP-------RKNRMGQRARRMIHEK-------KFGRGA 431 
ERS97129      490 KHvLEQEKKGTDAGGKDGGKDKKank---------------------------------------ngkQKDggGGWD--- 527 
EKD01031     1066 KHiVKQREEEKKKAAKKEGRVGGsnf---------------------------------------vppSRD--SGYK--- 1101
Q5KCW5        425 KH-VVKAHEEEKLQAQKTREKAEak-----------------------------------------grTRD--SGWG--- 457  Cryptococcus ...
XP_001835950  361 NH-KKAEAKAApttavkqn-----------------------------------------pegrsfahPKQprGG----- 393 
2_pfamImport  314 NH-VKRYQDDPSRRERPTERRRGsqplgqrnsdrp---------------------rkrdtsnqqhqqPPD--AGWNrre 369 
EMD39958      358 NH-VKKEHETTAQNPRQKG------------------------------------------------------AGWNqkg 382 
XP_007399343  332 NHfKKRETFGAVKGYPNKTSDRDvngsrdnprgns----------------------qankrphaqaqSRN--VTYSqr- 386 
NP_492224     376 NKsTKKPTKSAPIVKKVEEKKVEenevsddesdqktlvmkvdlskggkiakaqkfsttapksakivapVSE--------- 446 
XP_006959516  360 NH-IQKK--FEEQKQLERAKKFGk-------------------------------------------nKLD--SGWKgrq 391 
XP_009269864  432 NH-VQKK--FEEDKQLERAKRMGr-------------------------------------------nKLD--SGWKgrq 463 
ERS97129      528 ---AKRGAVDASDK--------PRWLrrkmgllgrvgp-----vggggkgagsnATPPAGAKKEIPNANAQVSGTLHPSW 591 
EKD01031     1102 ---TYRPAPESAPVlakpggtfGSSApar-----------------------tpGAATAGGASGPGAGGDEKKGKNHPSW 1155
Q5KCW5        458 ---AKSGKAVGPAVaagpaqtaA-------------------------------VSHTQKVYSEPKQSQTEQKKSLHPSW 503  Cryptococcus ...
XP_001835950  394 ---VRRGPLVSGPNsaaiqgkqRAF-----------------------------GQKPPTGAAAPSTNSNPSNKPLHPSW 441 
2_pfamImport  370 psnSHTKSIVGT------------------------------------------RSTIVSSAGSSQRNDRHDERPLHPSW 407 
EMD39958      383 gprNAGPPGRRGPPpsqvrpnvPHQ-----------------------------GHASEGRPQPRPTKTEVQDKPLHPSW 433 
XP_007399343  387 -----------------------------------------------------aSSSHVSSVQTGPTTRKERDKPLHPSW 413 
NP_492224     447 ---------DENDDdesssfflPKSGvvaprkiipkkpsenvekvdkrfqkgtqKKSEAVVEKKKGSSKSAVSGEMHPSW 517 
XP_006959516  392 qqqsggykeaerkdfk-------------------rdfkkfdknakqdgksgsgRPPPRNNKPPQKPTKAEDEGPLHPSW 452 
XP_009269864  464 qrqsedqkpnkdlnggykkdf---------kkdnktdsnhsskhdrgyknhskpHSKPSVPIKPGTDAAADDQGQLHPSW 534 
ERS97129      592 EAARKAKD--KAQTAAFEGKKIVFD 614 
EKD01031     1156 EAARRRKEaeQKLKNAPKATKIVFD 1180
Q5KCW5        504 EAAKLRKQkmGVVQTEIKAQKIVFD 528  Cryptococcus neoformans
XP_001835950  442 EAKKKLKEk-QSGIVPSQGKKIKF- 464 
2_pfamImport  408 EAKKKQK---TAGIVPSQGKKIVF- 428 
EMD39958      434 EAKKRLKEkqNPTIMAPQGKKITFs 458 
XP_007399343  414 EAKRKLKEkqNPALIAPRGKKIVFe 438 
NP_492224     518 IASQLKKK--ELASAKPCGKKITFg 540 
XP_006959516  453 AAKKAQAKaiENAPAP---TKITFD 474 
XP_009269864  535 AAKKAQAEaiANAPAP---TKITFD 556 
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