Conserved Protein Domain Family
Hpre_diP_synt_I

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pfam07456: Hpre_diP_synt_I 
Heptaprenyl diphosphate synthase component I
This family contains component I of bacterial heptaprenyl diphosphate synthase (EC:2.5.1.30) (approximately 170 residues long). This is one of the two dissociable subunits that form the enzyme, both of which are required for the catalysis of the biosynthesis of the side chain of menaquinone-7.
Statistics
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PSSM-Id: 429470
Aligned: 34 rows
Threshold Bit Score: 88.3822
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0AVK2         12 LLSLAIILHLFEALIPIPFPIPGVKLGLANIVTLLALVLFDFKTAFLIAFLRTMLGSLLSGTIfNiAFFLSFAGAITSTC 91  Syntrophomonas...
Q9X1P1         40 LTALSSTFYVLENLLPFPV--PFGRWGFSNSVVLMIASEIGFGDALIVASAKSILGALFSGRFlSpSFLTGFFGAVSASL 117 Thermotoga mar...
Q8RGD4         15 LVLLGLYLSLIENIIPKPF--PWMKIGLSNISVLIAFEKFNSKMALQTILLRVFIQALMLGTLfTpNFIISFSAGLISTL 92  Fusobacterium ...
Q73LD9         22 FGGFCFFLSAIEIMIPKPV--PFFRIGLANLPVILGIDLFSFPAFVLLLVIKVLGQALISGTLfSyIVLFSAIGTFSSGL 99  Treponema dent...
O83368         20 LGGMCFFLSTVEHVIPKPL--PFFRVGLANLPLLISPDLLPFCAYARLVFLKVIGQALVSGTLfSyVFVLSLAGSTASGA 97  Treponema pall...
Q67R05         44 LTAAGLALALLERQLPPPAPVPGVRWGLANAATLAALALDGPAAGLLVWFCRFILAQIFAGTLfGpAFFVGGAGGLLAWA 123 Symbiobacteriu...
Q3A8J2         20 FSALAIGVHTLEVLLPSPL--PWLRLGLANILTLCALFLYGGRAAWLVTFTRIGIGSLLLGTLfSpTFFLALAGGTIATA 97  Pelobacter car...
jgi:Mmc1_0235  17 LAVAAVAAHMLEATLPGLG--PWFKPGLANVFTVVAFFYLDREAAIWVALIRVLGGSLAMGAFlTpSFFLSGAGMLGAIV 94 
Q3SF14         20 LAAVAIGITLAEAAIPSPV--PGIKPGLANIVVLLVLLQYGWRTAAWVSAMRVLAGSLLLGSLfApGFWLSAAGATVSLL 97  Thiobacillus d...
Q5P3C7         20 LATAAIVLTVAEAAIPLPL--PGVKPGLGNIVILIVLLRWGWRDAVWVGLLRVFASSLLLGQLfApGFFLSLAGSLTSLA 97  Aromatoleum ar...
Q0AVK2         92 FMAILlFLLPpifhhyDRGFSLVGISIGGAAAHNLGQLAMAAL-L------IKHSGIFYYLPIMLLSSIPTGFLTGLILR 164 Syntrophomonas...
Q9X1P1        118 VESFL-ARFD---------FGYLSLSAMGSFVNNLVQLIVISF-L------VGSTKTFLLFPLMVILGLVSGTVNAFLAS 180 Thermotoga mar...
Q8RGD4         93 FMIFL-YNF-------RKYLSLLSISCISAFTHNLLQLIVVYF-LlfrnisLNSKSIIIFIVIFLGLGVIMGLITGIITT 163 Fusobacterium ...
Q73LD9        100 LMYAM-RKIP------RKTISFMGISLAGAFVSNSLQFLLAVL-L------MFGKSAVYIIPPVFSLGTLTALFLGWFAS 165 Treponema dent...
O83368         98 LMYAL-RFVP------CRYLSCVGISVMGAFCSNVIQLTLARV-L------VFGAGVWYVLPLFCALGAVSSTLLGALTG 163 Treponema pall...
Q67R05        124 AMALF-AR--------GRRLGPAGVSAAGAVAHHVGQLAAAAA-V------TSTPGVLALLPLLLVLGPPVGLLTGALVG 187 Symbiobacteriu...
Q3A8J2         98 LMTTA-HVLA------GCRLSPVGVSLLGAVGHLFGQLLVAGW-L------LQHDGLWRLLPLLLVLGLVTGTINGLAAN 163 Pelobacter car...
jgi:Mmc1_0235  95 VMLLP----P------LPGMGAVGLSILMALAHMCAQVAAAHLlF------VQHSGLFYLLPWFLLGAWCTGWFNGVLAH 158
Q3SF14         98 VLGLA-RHLP------ARYFGPVSLSILAAFGHIGGQLALAGWwL------LPGAALIGLIPVFAAAALIFGTVNGVVVA 164 Thiobacillus d...
Q5P3C7         98 TLGVA-KHLP------RRWFGPVSLSVFAAFAHIGGQLALARAwL------VPHDGVFYLVPVFAAAATLFGLINGLVAA 164 Aromatoleum ar...
Q0AVK2        165 E----L 166 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
Q9X1P1        181 RmggiV 186 Thermotoga maritima
Q8RGD4        164 Kinlkr 169 Fusobacterium nucleatum subsp. nucleatum
Q73LD9        166 E----F 167 Treponema denticola
O83368        164 H----F 165 Treponema pallidum
Q67R05        188 L----L 189 Symbiobacterium thermophilum
Q3A8J2        164 L----L 165 Pelobacter carbinolicus DSM 2380
jgi:Mmc1_0235 159 G----L 160
Q3SF14        165 R----L 166 Thiobacillus denitrificans ATCC 25259
Q5P3C7        165 Rl---L 167 Aromatoleum aromaticum EbN1
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