Conserved Protein Domain Family
CrmD_SECRET
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pfam07190: CrmD_SECRET (This model is not part of the current CDD release)
Tumour necrosis factor receptor, SECRET domain
This domain, named as the SECRET domain, is found at the C-terminal end of Tumour necrosis factor receptor (CrmD) from the orthopoxvirus Ectromelia virus. This domain binds a subset of human and mouse CC, CXC and C chemokines. It is thought to be responsible for the anti-chemokine activity of CrmD. The SECRET domain monomer adopts a beta-sandwich fold, consisting of two parallel beta-sheets with five and six anti-parallel strands, and the connecting loops. This domain is also found in other uncharacterised sequences from poxvirus, including Protein OPG192 and Protein C8 from Vaccinia virus.
Links
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Statistics
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PSSM-Id: 517602
Aligned: 4 rows
Threshold Bit Score: 162.237
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0GP69       1 MSAIRFIACLclIFV---LGNCHddPYYQP------------FNKLNITLDIYTYeDL-VPYTV-DNDTTSFVKIYFKKF 63  Horsepox virus
Q8QN47       1 MINININTIL--IFAslfVASFA--NDYPPpgffedkyitntFNYISIDFELYPV-NV-SSCNR-LSTKQSSDVISTSEL 73  Cowpox virus
Q0NPJ0       1 MSSIRFIACLylISV---FGNCHedPYYQP------------FDKLNITLDIYTYeDL-VPYTV-DN------------- 50  Taterapox virus
A0A7H0DNF4   1 MYK-KLITFLfvIGA---VASYSn-NEYTP------------FNKLSVKLYIDGVdNIeNSYTDdNN----ELVLNFKEY 59  Monkeypox virus

Q0GP69      64 WITVMTKWCAPFIDTvSVYTSHDNLNIEFYTRDEYDTQSEDKICTIDVKARCNHLTKPE-VTVQK-EAYRYSLSSD---- 137 Horsepox virus
Q8QN47      74 TITVNSTDCDPVFVT-EYYSVKDKTAIAGLFTDTTKKQNTSKMCTLNIEVKCNAETEPVlIGNFTrVPEKASTHAEnftl 152 Cowpox virus
Q0NPJ0      51 ----------------DLPNPNDYQ------------------------------------------------------- 59  Taterapox virus
A0A7H0DNF4  60 TISIITESCDVGFDSiDIDVINDYKIIDMYTIDSSTIQRRGHTCRISTKLSCHYDKYPY-IHKYEgDERQYSITAE---- 134 Monkeypox virus

Q0GP69     138 -LSCFDSIDLNIDLIEtnsTDTTVLK-SYELMLPKr--------------AKSI 175 Horsepox virus
Q8QN47     153 iGNCLSDLHLYIAYVN---TDEEFEEdTATVHIGN---------------KLDI 188 Cowpox virus
Q0NPJ0      60 -------------LLS--------LR--YTLKIFG------------------L 72  Taterapox virus
A0A7H0DNF4 135 -GKCYKGIKYEISMMN----DDTLLR-KHTLKIGFtyifdrhghsntyysKYDF 182 Monkeypox virus
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