1FJR


Conserved Protein Domain Family
Methuselah_N
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pfam06652: Methuselah_N 
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Methuselah N-terminus
This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site. This family is found in conjunction with pfam00002.
Links
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Statistics
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PSSM-Id: 429053
Aligned: 31 rows
Threshold Bit Score: 202.873
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1FJR_A                5 CDYFDTVDISAAQKLQN------GSYLFEGLLVPAILTGEYDFrILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMD 78 
Q9W0R6               29 CAYAHTVNITDGLRMKD------GSYSYAGVVVPPHLMAEYSF-KVIDGVEYRAKKHLRGCVCLLKPCISFCCPENLVFD 101 fruit fly
XP_001955866         29 CAYANTVNITDGLRLKD------GSYSYAGLVIPPNMIAEYSF-KVIDGVQYRAKKHLRGCACLQKACISFCCPPDLVFD 101
EDV95978             33 CPYADTVNITDGLRLRD------GSYSFAGVLVPAELTAEYNF-KVIDGVEYKAARHLRGCVCQIKPCITFCCPPDLVFN 105
XP_002012034         31 CAYADTVNITDGLRLKD------GSYSYAGVLIPPELMAEYSF-KVIDGVEYRAEKHLRGCVCQLKPCITFCCPPDLVFN 103
WGS:AAQB:GK21004-PA  40 CAFIDTTNISGSYAMDSsf---nGSYIHNWTVIPREWVAIYDF-VIEDGVRVPARRHLRGCVCKQTPCVRFCCPDGQIYD 115
WGS:AANI:GJ12496-PA  32 CAFIDTANITGGYNMGNlggslnGSYVYNWTVIPKELVTAYDF-VIENGIRVPAARHLRACVCKLRPCVRFCCPAGQLYE 110
XP_002012035         31 CAFIDTVNITGSYNMGSsl---nNSYVHNWTVIPRELVTAYDF-IIENGIRVPAKRHLRACICKLRPCVRFCCPAGQFYD 106
NP_001261182         30 CAFIDTANITGSYGLD-------GPFVHNWTVIPRHFVAVYDF-VIENGIRIPASRHLRACVCKTKPCVRICCLRGEIYD 101
WGS:AAPP:GF24878-PA  29 CAFIDTANITDTPGRVGd----nATYFYNWTPIPHHLVAVYDF-VIDNGIRIPARKHLRACVCRLKPCVRICCPSGHLYD 103

1FJR_A               79 NG--VCYDNm---SdEELAELD-PFLNVTLDd-GSVSRRHFKNELIVQWDLPmpCDGMFYLDNReeqdKYTLFENGTFFR 151
Q9W0R6              102 AKhwNCTMPhqvrEs--------THVELTYAn-RTVDQVRIRDRFVVRTELG--CRNKFVDKKHdnfwQWDLFENGTLRR 170 fruit fly
XP_001955866        102 SKhwNCSQPhqirEs--------THIELTYGn-RSVENVRIKDRFLVRTELG--CRNKFVDRKHesfwKWDLFENGSLFR 170
EDV95978            106 AQrwNCTRPnqvrQi--------THIELSASgnRSVEQVKIMDHFVVRTELG--CRNKFVDSNHdsfwQWDLHANGSLQR 175
XP_002012034        104 AEswNCTKPkqerLi--------SHVELTYAn-LSVAQVKISEHFVVRTELG--CRNKFVDKKHdtfwQWDLHENGSLLR 172
WGS:AAQB:GK21004-PA 116 LNekQCRQPhs-mS-VNNLPPDhSHMDIELNn-GSLRHIELRSLYSIHVETP--CKHMKALRKNmeyvHWTLHENGTITH 190
WGS:AANI:GJ12496-PA 111 LQrrRCVAPt---G-DGPQPPGhSHMTVELHn-GSRLSIELRARFSVHVETP--CDHMRALTKDsvylNWTLHENGSITH 183
XP_002012035        107 LEerSCLAAq---E-QLPPPPGqSHMAVQLHn-GTQLDIELRSLFSVYEETP--CDHMKAYTKDntylNWTLHENGSIIH 179
NP_001261182        102 LEkrQCLVPv---A-GVSSLPShSHMEVELGn-GSLRLVKLQPRFSIHVETP--CEHMKAVTKGseyvHWTLHENGTISH 174
WGS:AAPP:GF24878-PA 104 ADtrQCSVPr---S-GLPPLPAhSHMEVELLn-GSLRRLELGPAFSIHIDTP--CKHMKPVTKGaeyvHWTLHENGTVSH 176

1FJR_A              152 HfdRVTLRKREYCLQHLTFADGnatsIRIAPHNC 185
Q9W0R6              171 D--NRLWSTDEYCFSPLEHNPEq---WELTPLNC 199 fruit fly
XP_001955866        171 E--NRVWSTDEYCFSPLEHKPEq---WELAPISC 199
EDV95978            176 D--DRLWSTDEYCFTPLEHN-Sa---WELAPLNC 203
XP_002012034        173 D--GRLWSTDEYCFTPLEHK-Da---WQLTPLNC 200
WGS:AAQB:GK21004-PA 191 ---RGHMFTKHYCFTPLQLANAs---WDWQPLAC 218
WGS:AANI:GJ12496-PA 184 ---REHLFTKHYCFTPLRVGNSs---WNWQPLAC 211
XP_002012035        180 ---RDYLFSKHYCFSPLLIGNSs---WSWQPLAC 207
NP_001261182        175 ---RGHIFSKHYCFTPLLHGNSt---WEWQPLAC 202
WGS:AAPP:GF24878-PA 177 ---RGHVFSKHYCFTPLLLGNSt---WDWQPLAC 204
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