1FJR


Conserved Protein Domain Family
Methuselah_N

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pfam06652: Methuselah_N 
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Methuselah N-terminus
This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site. This family is found in conjunction with pfam00002.
Statistics
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PSSM-Id: 310923
View PSSM: pfam06652
Aligned: 33 rows
Threshold Bit Score: 199.781
Threshold Setting Gi: 29337243
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FJR_A          5 CDYFDTVDISAAQKLQ---N------GSYLFEGLLVPAILTGEYDFrILPDD-SKQKVARHIRGCVCKLKPCVRFCCPHD 74
gi 121992929   57 CTFFDTVNLTGYTPFP---N------GSYSYEGVLIPSHLVGQYNY-IYKDLvERVDVDWHPRGCICRLKACLNICCPWG 126
gi 964135411   53 CKFHDTVNLTGHTRFP---N------GSYEYEGIIIPEHLVGNYDYvFRSLA-DRVEVPNHVRGCVCKLKPCLNICCPWG 122
gi 968034819   67 CSFFDTVNLTGYPSFP---N------GSYNYEGVIIPSHYVGTFDY-IYKDLvDRIDVTPHVRGCICKLKPCINICCPWG 136
gi 195375325   32 CAFIDTANITGGYNMG---NlggslnGSYVYNWTVIPKELVTAYDFvI-ENG-IRVPAARHLRACVCKLRPCVRFCCPAG 106
gi 195435986   40 CAFIDTTNISGSYAMDssfN------GSYIHNWTVIPREWVAIYDFvI-EDG-VRVPARRHLRGCVCKQTPCVRFCCPDG 111
gi 195012410   33 CAFIDTVNITGSYRMDgslN------NSYVHNWTVIPKEFVTDYDFvI-ENG-IRVPTERHLRACICKQRPCVRFCCPNG 104
gi 19922966    30 CAFIDTANITGSYGL----D------GPFVHNWTVIPRHFVAVYDFvI-ENG-IRIPASRHLRACVCKTKPCVRICCLRG 97
gi 1013919380  30 CAFIDTANITESYGLD----------GPFVHNWTVIPRHFVAVYDF-VIKNG-IRIPANRHLRACVCKTKPCVRICCLWG 97
gi 15428722    17 CNFYDTVNLTGHRLFP---N------GSYDYYGTIVPAELVGTYDY-IHSSLtERIEVREHVRGCVCKFKSCLNICCPWR 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FJR_A         75 HIMD-N-G--VCYDNm--SdeelaeldPFLNVTLDDGSVSRRHFKNELIVQWDLPmpCDGMFYLDNREE-QdK-YTLFEN 146
gi 121992929  127 QVYN-S-EkeECNNDt--Tdtri-wpqPVMNVTFDNSSTQSVNIFKQFAVQSFRP--CPKMFSLQPEINdFdD-YLLFQN 198
gi 964135411  123 QIYN-S-GrgECMNDt--Mdhre-wpkPVLNVTFAENITMEVNISQQFAVQSFRP--CAKMFSLQPEIN-DfDaYLIFQN 194
gi 968034819  137 QIYN-Y-Te--CQKDt--Ntkqk-wpePLINVTLNNGSVQSVNIYEQFVVQSFRP--CTEMFSLVPEVN-SyDtFQLYEN 206
gi 195375325  107 QLYE-L-QrrRCVAPt--GdgpqppghSHMTVELHNGSRLSIELRARFSVHVETP--CDHMRALTKDSV-YlN-WTLHEN 178
gi 195435986  112 QIYDlN-Ek-QCRQPhsmSvnnlppdhSHMDIELNNGSLRHIELRSLYSIHVETP--CKHMKALRKNME-YvH-WTLHEN 185
gi 195012410  105 QLYD-LqDh-KCVPHs--AehpqppghSHMTVGLRNGTQLQMEIASRFSVHVETP--CDNMRAVIKDGD-YfN-WTLYED 176
gi 19922966    98 EIYD-L-EkrQCLVPv--AgvsslpshSHMEVELGNGSLRLVKLQPRFSIHVETP--CEHMKAVTKGSE-YvH-WTLHEN 169
gi 1013919380  98 EIYD-L-GrrQCLVPa--ArvsslpshSHMEVELGNGSLRLVKLQPRFSIHVETP--CEHMKAVTKGSEyV-H-WTLHEN 169
gi 15428722    87 QVFN-S-EvdGCIIDh--SdnrtwpdpPMLNITFRNESTILVNMFTQFAIQSFRP--CPKMFSLQPETNnWdD-YLLFEN 159
                         170       180       190
                  ....*....|....*....|....*....|....*....
1FJR_A        147 GTFFRHfdRVTLRKREYCLQHLTFADGNatsIRIAPHNC 185
gi 121992929  199 GSMLRLddHNYINKSEFCLVVSYVNETDl-yYSLNPANC 236
gi 964135411  195 GSMFRVddKVFIEKNQYCLVPTFVNESDl-vYSLNPANC 232
gi 968034819  207 GTLFREddQHYIFKNEFCLVPTSINDTDl-yYTINPANC 244
gi 195375325  179 GSITH---REHLFTKHYCFTPLRVGNSS---WNWQPLAC 211
gi 195435986  186 GTITH---RGHMFTKHYCFTPLQLANAS---WDWQPLAC 218
gi 195012410  177 GSIIH---REHLFTKHYCYTLVLLGNRT---WSWQPLAC 209
gi 19922966   170 GTISH---RGHIFSKHYCFTPLLHGNST---WEWQPLAC 202
gi 1013919380 170 GTISH---RGHIFSKHYCFTPLLHGNST---WEWQPLAC 202
gi 15428722   160 GSMLRVddKLLIRKNEFCMVPTYVNESDm-fYTIHPANC 197
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