1FJR


Conserved Protein Domain Family
Methuselah_N

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pfam06652: Methuselah_N 
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Methuselah N-terminus
This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site. This family is found in conjunction with pfam00002.
Statistics
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Aligned: 34 rows
Threshold Bit Score: 199.006
Threshold Setting Gi: 29337243
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1FJR_A                5 CDYFDTVDISAAQKLQN------GSYLFEGLLVPAILTGEYDFrILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMD 78  fruit fly
Q9W0R6               29 CAYAHTVNITDGLRMKD------GSYSYAGVVVPPHLMAEYSF-KVIDGVEYRAKKHLRGCVCLLKPCISFCCPENLVFD 101 fruit fly
WGS:AAPP:GF24877-PA  29 CAYANTVNITDGLRLKD------GSYSYAGLVIPPNMIAEYSF-KVIDGVQYRAKKHLRGCACLQKACISFCCPPDLVFD 101 Drosophi...
EDV95978             33 CPYADTVNITDGLRLRD------GSYSFAGVLVPAELTAEYNF-KVIDGVEYKAARHLRGCVCQIKPCITFCCPPDLVFN 105 Drosophi...
WGS:AAPU:GI16746-PA  31 CAYADTVNITDGLRLKD------GSYSYAGVLIPPELMAEYSF-KVIDGVEYRAEKHLRGCVCQLKPCITFCCPPDLVFN 103 Drosophi...
WGS:AAQB:GK21004-PA  40 CAFIDTTNISGSYAMDSsf---nGSYIHNWTVIPREWVAIYDF-VIEDGVRVPARRHLRGCVCKQTPCVRFCCPDGQIYD 115 Drosophi...
WGS:AANI:GJ12496-PA  32 CAFIDTANITGGYNMGNlggslnGSYVYNWTVIPKELVTAYDF-VIENGIRVPAARHLRACVCKLRPCVRFCCPAGQLYE 110 Drosophi...
WGS:AAPU:GI16747-PA  31 CAFIDTVNITGSYNMGSsl---nNSYVHNWTVIPRELVTAYDF-IIENGIRVPAKRHLRACICKLRPCVRFCCPAGQFYD 106 Drosophi...
AAL39868             30 CAFIDTANITGSYGLD-------GPFVHNWTVIPRHFVAVYDF-VIENGIRIPASRHLRACVCKTKPCVRICCLRGEIYD 101 fruit fly
WGS:AAPP:GF24878-PA  29 CAFIDTANITDTPGRVGd----nATYFYNWTPIPHHLVAVYDF-VIDNGIRIPARKHLRACVCRLKPCVRICCPSGHLYD 103 Drosophi...
1FJR_A               79 NG--VCYDNm---SdEELAELD-PFLNVTLDd-GSVSRRHFKNELIVQWDLPmpCDGMFYLDNReeqdKYTLFENGTFFR 151 fruit fly
Q9W0R6              102 AKhwNCTMPhqvrEs--------THVELTYAn-RTVDQVRIRDRFVVRTELG--CRNKFVDKKHdnfwQWDLFENGTLRR 170 fruit fly
WGS:AAPP:GF24877-PA 102 SKhwNCSQPhqirEs--------THIELTYGn-RSVENVRIKDRFLVRTELG--CRNKFVDRKHesfwKWDLFENGSLFR 170 Drosophi...
EDV95978            106 AQrwNCTRPnqvrQi--------THIELSASgnRSVEQVKIMDHFVVRTELG--CRNKFVDSNHdsfwQWDLHANGSLQR 175 Drosophi...
WGS:AAPU:GI16746-PA 104 AEswNCTKPkqerLi--------SHVELTYAn-LSVAQVKISEHFVVRTELG--CRNKFVDKKHdtfwQWDLHENGSLLR 172 Drosophi...
WGS:AAQB:GK21004-PA 116 LNekQCRQPhs-mS-VNNLPPDhSHMDIELNn-GSLRHIELRSLYSIHVETP--CKHMKALRKNmeyvHWTLHENGTITH 190 Drosophi...
WGS:AANI:GJ12496-PA 111 LQrrRCVAPt---G-DGPQPPGhSHMTVELHn-GSRLSIELRARFSVHVETP--CDHMRALTKDsvylNWTLHENGSITH 183 Drosophi...
WGS:AAPU:GI16747-PA 107 LEerSCLAAq---E-QLPPPPGqSHMAVQLHn-GTQLDIELRSLFSVYEETP--CDHMKAYTKDntylNWTLHENGSIIH 179 Drosophi...
AAL39868            102 LEkrQCLVPv---A-GVSSLPShSHMEVELGn-GSLRLVKLQPRFSIHVETP--CEHMKAVTKGseyvHWTLHENGTISH 174 fruit fly
WGS:AAPP:GF24878-PA 104 ADtrQCSVPr---S-GLPPLPAhSHMEVELLn-GSLRRLELGPAFSIHIDTP--CKHMKPVTKGaeyvHWTLHENGTVSH 176 Drosophi...
1FJR_A              152 HfdRVTLRKREYCLQHLTFADGnatsIRIAPHNC 185 fruit fly
Q9W0R6              171 D--NRLWSTDEYCFSPLEHNPEq---WELTPLNC 199 fruit fly
WGS:AAPP:GF24877-PA 171 E--NRVWSTDEYCFSPLEHKPEq---WELAPISC 199 Drosophila ananassae
EDV95978            176 D--DRLWSTDEYCFTPLEHN-Sa---WELAPLNC 203 Drosophila grimshawi
WGS:AAPU:GI16746-PA 173 D--GRLWSTDEYCFTPLEHK-Da---WQLTPLNC 200 Drosophila mojavensis
WGS:AAQB:GK21004-PA 191 ---RGHMFTKHYCFTPLQLANAs---WDWQPLAC 218 Drosophila willistoni
WGS:AANI:GJ12496-PA 184 ---REHLFTKHYCFTPLRVGNSs---WNWQPLAC 211 Drosophila virilis
WGS:AAPU:GI16747-PA 180 ---RDYLFSKHYCFSPLLIGNSs---WSWQPLAC 207 Drosophila mojavensis
AAL39868            175 ---RGHIFSKHYCFTPLLHGNSt---WEWQPLAC 202 fruit fly
WGS:AAPP:GF24878-PA 177 ---RGHVFSKHYCFTPLLLGNSt---WDWQPLAC 204 Drosophila ananassae
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