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Signal-peptide peptidase, presenilin aspartyl protease SPP is a family of signal-peptide aspartyl proteases. The family carries the characteriztic catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type with nine transmembrane regions. UniProtKB:Q18K19 is part of the TCDB family 1.A.54.3.4, the presenilin er Ca(2+) leak channel (presenilin). |
Jiyao W et al.(2023). "The conserved domain database in 2023.",