Conserved Protein Domain Family
MelC1

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pfam06236: MelC1 
Tyrosinase co-factor MelC1
This family consists of several tyrosinase co-factor MELC1 proteins from a number of Streptomyces species. The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase MelC2 to facilitate the incorporation of copper ion and the secretion of tyrosinase indicating that MelC1 is a chaperone for the apotyrosinase MelC2.
Statistics
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PSSM-Id: 399323
Aligned: 7 rows
Threshold Bit Score: 94.9367
Threshold Setting Gi: 81623335
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFG04697      21 VTGAAAGSAlaGLATATADSpp-pAKATAAPagttgPDSFDEVFQGRRIQGLPAEGGaahargahargahGHAGHGP--- 96  Streptomyces cl...
WP_015662974  15 ALAAASGAA--TLAAPAARAa---GHHPGSS-----PAPFDEVYKGRRIQGRAASGG-------------GHHDHGG--- 68  Streptomyces da...
WP_015038019  14 AAGAAAGAA--GLALAGSSVadapRPAAPAAg----PAPFDEVYQGRRITGGPAHGGg-----------hHGGHHGG--- 73  Streptomyces
Q9KYH1        60 AEAATTGPL---PAHPGPHAaesaESVEGAAegv-egAAFDETYRGRRIRGIRSa--------------aGRAVGAG--- 118 Streptomyces co...
AEV85905      16 ATVVTGGVAgaQALSTSSSSaqapAGARTSAd----PRDFDVEYRGKRITGv-----------------hGADTPGAlrs 74  Actinoplanes sp...
EST19890      15 ALAATATVT--ALAAPTASAa---GHGRPMPmp-kpPENFDEVYKGRRIQGRPMSGGg-----------hHHHEHGS--- 74  Streptomyces ro...
WP_020938192  15 ALAATAGAA--GLVAPAASAapatGHQHGS------PESFDEVYKGRRIQGRPSGMGs------------HHHEHGG--- 71  Streptomyces co...
EFG04697      97 ------AYRVLIDGRELHVMR----HGKM----GWSSAINHYERFATP--------LDAARTAVVSLKGAAVVPF 149 Streptomyces clavuli...
WP_015662974  69 ------GYGVFVDGVELHVMR----NADG----SWISVVSHYDPVATP--------RAAARAAVDELQGAALLPF 121 Streptomyces davaone...
WP_015038019  74 ------GYSVTIDGAELHVMQ----NADG----TWISVINHYEPVATP--------KALARAAVRELQGAPLVPL 126 Streptomyces
Q9KYH1       119 ------TWQVTVDGRPLHLMR----RADG----SWLSMVDHYRSYPTP--------LAAARGAVDELGPGEHLRD 171 Streptomyces coelicolor
AEV85905      75 vsgsrqPHQVHINGRRLAVMQielpAAGGgvtlGFISALNHYEPVLIDtdknrdglLKLTRRAVDALGDSELTal 149 Actinoplanes sp. SE5...
EST19890      75 ------GFEVLIDGVQLHVMR----NADG----SWISIVSHYDPVTTP--------RAAARAAVDELQGAALLPF 127 Streptomyces roseoch...
WP_020938192  72 ------GWSVFVDGVELHVMR----NADG----SWISVVSHYDPVPTP--------RAAARAAVDELQGAPLLPF 124 Streptomyces collinus
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