3NO4


Conserved Protein Domain Family
Creatininase

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pfam02633: Creatininase 
Creatinine amidohydrolase
Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.
Statistics
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PSSM-Id: 396965
Aligned: 404 rows
Threshold Bit Score: 96.1556
Threshold Setting Gi: 347945022
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NO4_A               31 EAY--LQQSK--GIIFPIGSTEQHGPTGLIGTDAICAEAIAAG----Vgd--aTG---------AI-----------VGP 80 
jgi:Sthe_1012        19 ADL--LKQRP--VGILPIGAIEAHGPDLPLGTDVIIATAIAER----A-----AAllte-eglpVL-----------VLP 73  Sphaerob...
jgi:Hoch_5093        15 AAL--PLRRT--AALLPVGAVEAHGPHLPLATDVIIAEAMARR----G-----AErlqa-rglsAV-----------LLP 69  Haliangi...
CAN92153             16 AAL--LSGGApcVALVPVGSVEPHGPHLPLGTDTLIGEAAAEQ----A-----GRrlwa-rgvaAL-----------LAP 72  Sorangiu...
WP_016332152         13 AALasDARVP--VLLLPVGAVEPHGPHAPLGTDPLISRGMCER----A-----AArlagdpglrVL-----------ILP 70  Amycolat...
CHGC:AMES_6860       13 ASLpdDERVP--VLLLPVGAIEPHGPHAPLGTDPLISRGMCER----A-----AErlaadddvhVL-----------VLP 70  Amycolat...
goetting:Awo_c31990  19 EAA--IKQNA--CVLLPVSVVEEHGPHLCTGTDIYLTQSLSQQ---------------------IKqklvaknhpvvIAP 73  Acetobac...
WP_010073837         19 ENL--IKQEA--VVLLPVAVIEEHGPHLPLGTDTYLTYAMFKH---------------------IQdeldkvnvksvIAP 73  Clostrid...
goetting:Awo_c33050  14 AQC--NKEKT--IVFIGFAPIEEHGRHLPLGVDVYETQYWMDNslskLevefg-------------------ehtflTMP 70  Acetobac...
6_pfamImport          7 CQV--LREKS--IAYLPVGPLEWHGPAMPYGTDAMAAGESARR----TamitgGA----------------------VVP 56 
3NO4_A               81 TINVGX-A---LHH-TA---FPGT--------------ISLRPSTLIQVVRDYVTCLAKAGFSKFYFINGHGG--NIATL 136
jgi:Sthe_1012        74 PLPYGA-S---FIA-TC---FPGT--------------SPAEPDAFRAYLTSVLLNLLPQGYRCICICNAHREpaHAEAV 131 Sphaerob...
jgi:Hoch_5093        70 PLAYTA-A---GFA-AG---FAGT--------------LAMRPETVTAMVVDIGRGLAAHGFGLLAIANAHLDptHIGSL 127 Haliangi...
CAN92153             73 PIGYGV-T---DFA-AG---FAGA--------------ISIPAPALTAFLRAVAEAYLSAGLSHVCFINNHLEpeHDRAV 130 Sorangiu...
WP_016332152         71 EVPYGV-T---RFA-AG---FAGG--------------VSIGEETLYALLTEICGALTEQGLTRILLVNNHFEpaHLAVL 128 Amycolat...
CHGC:AMES_6860       71 EVPYGV-T---RFA-AG---FAGG--------------IHIGEETLHSLLVDIGAALIAQRLGRILLVNNHFEpaHLVTL 128 Amycolat...
goetting:Awo_c31990  74 PFYWGV-N-------SItdgFVGS--------------FSIKPETMTLMLLEILENLNKWGFKKIFLLNFHGDfiHIKTI 131 Acetobac...
WP_010073837         74 PFYWGI-N-------VAtsgFPGS--------------FTVKVDTMKAVLKDTIECLYNWGFKNVYILNMHGDslHSKTI 131 Clostrid...
goetting:Awo_c33050  71 VITYGH---------ASmkgLPGN--------------IHLSQQLLYELVLVTVDNILEWGIKNIVIISGHADpkHTIAI 127 Acetobac...
6_pfamImport         57 TMFMGTeTprdNEFlQTaglQPNTyvvgmdfpknsipsMYLRAELFAVMLREQVRLLVNLGFKLIVIVNGHGAvaQEEAI 136
3NO4_A              137 KAAFSETYah---lEDLqianaqQvq---------------------cQVANWFXCGSVYKLAK-------ELYGDQEg- 184
jgi:Sthe_1012       132 WASARAAA------AAT------G------------------------VPAVFPDVRDSRWASV-------LGDEFRSr- 167 Sphaerob...
jgi:Hoch_5093       128 KRAGEELAd-----SGV------T------------------------IGFAFPDVTRKPWALR-------LSDEFRSg- 164 Haliangi...
CAN92153            131 RAATSDLPlg---rASV------A------------------------CPLA------RRWART-------LSAEFRSg- 163 Sorangiu...
WP_016332152        129 RRVAET--------AG----------------------------------VGFVDLVRRRYAAR-------LTDEFRSg- 158 Amycolat...
CHGC:AMES_6860      129 RRAAETLNfa--ydGR----------------------------------VALLELVRRRHAER-------LTDEFRSg- 164 Amycolat...
goetting:Awo_c31990 132 VEIVAHANkm---nIEA------Yfll-------------------dkNLLSQMHFNQDLSYLVsieldprKVNLETTvi 183 Acetobac...
WP_010073837        132 VETVKEIYev---sQKD------Kkvyniipef------fqkimglddSEPYLLIQKEDHDEPP-------VNDENPYm- 188 Clostrid...
goetting:Awo_c33050 128 EQVCEKVNnengivAFA------PmgaifsgevaiadenqdpdmkqkmMAFPn--------------------------- 174 Acetobac...
6_pfamImport        137 HRIAKETTaetdstVIG------Vraty-----------------alkEGDLn--------------------------- 166
3NO4_A              185 -SHATPSEVALTQYVYPEAIKQAPL-----SPEVASgh--rIYSAADFRVRY-PDG---RX---Gs----------NPGL 239
jgi:Sthe_1012       168 pRHAGRAETSIMLAAQPGAVLHDGMahlpeVPIDLP-----ARLRKGARTLS-EAGgtlGYf--G-----------DPAR 228 Sphaerob...
jgi:Hoch_5093       165 aCHAGQYEGSMVLAERPELVREELRaqlapNPASLS-----VAIRAGHTSFE-EAGgprAYf--G-----------DPAA 225 Haliangi...
CAN92153            164 aCHAGRYETSLVLAAASALVRKDIAealpdLGLSLS-----EGIKAGAKSFR-ALGmdaAYt--G-----------SPRE 224 Sorangiu...
WP_016332152        159 eCHAGQYETSLVLADRPDLVDATVQralpaVHVDL--------ARGGVTDFA-SAGmteAYc--G-----------TPAQ 216 Amycolat...
CHGC:AMES_6860      165 eCHAGRYETSLVLADRPELVDQTLMrtlphVPVSL-------AAAPADGGFR-EMGmtdAYc--G-----------KPAE 223 Amycolat...
goetting:Awo_c31990 184 dIHAGATETSWMALSYNKLVDTEKAktlkpTNLTRSdlkewLKGGEVAKSVT-PLG---YC---G-----------NPSN 245 Acetobac...
WP_010073837        189 dIHAGGFETSLMLLEFKELVNEEMAkgfesSKTTFEllrkwQQGGVEGREIT-PLG---YC---G-----------NPSN 250 Clostrid...
goetting:Awo_c33050 175 dFHAGWIETSNMLEIRKDLVKHDFIkqpdiVVSDKE-----MINPEVVMKKTaGYG---HL---G-----------YPKE 232 Acetobac...
6_pfamImport        167 gGHGSVKETAVQMYLNGGSVDLSKFppreeP---------------LRMP---DYG---ILnlfGphfpkdmimdpDPRD 225
3NO4_A              240 ATPEHGKQFYDLAVK 254
jgi:Sthe_1012       229 ANAAEGERLLASLAG 243 Sphaerobacter thermophilus DSM 20745
jgi:Hoch_5093       226 ATADEGQATIATLGE 240 Haliangium ochraceum DSM 14365
CAN92153            225 ASEDEGRALLDLLAT 239 Sorangium cellulosum So ce56
WP_016332152        217 ATAEEGEKTFSVLTD 231 Amycolatopsis keratiniphila
CHGC:AMES_6860      224 ATAREGEETFSTLTD 238 Amycolatopsis mediterranei S699
goetting:Awo_c31990 246 IDL----KKIKTLTA 256 Acetobacterium woodii DSM 1030
WP_010073837        251 INLKEAKEFTDAFVK 265 Clostridium cellulovorans
goetting:Awo_c33050 233 ASVALGKTLNHSVIE 247 Acetobacterium woodii DSM 1030
6_pfamImport        226 ATAELGKQYLEHGAE 240
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