3NO4


Conserved Protein Domain Family
Creatininase

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pfam02633: Creatininase 
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Creatinine amidohydrolase
Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.
Statistics
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PSSM-Id: 426892
Aligned: 382 rows
Threshold Bit Score: 97.7011
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NO4_A               31 EAYlq--qsK--GIIFPIGSTEQHGPTGLIGTDAICAEAIAAG----VGDA--Tg---------AI-----------VGP 80 
jgi:Sthe_1012        19 ADLlk--qrP--VGILPIGAIEAHGPDLPLGTDVIIATAIAER----A-----Aallte-eglpVL-----------VLP 73 
jgi:Hoch_5093        15 AALpl--rrT--AALLPVGAVEAHGPHLPLATDVIIAEAMARR----G-----Aerlqa-rglsAV-----------LLP 69 
CAN92153             16 AALls--ggApcVALVPVGSVEPHGPHLPLGTDTLIGEAAAEQ----A-----Grrlwa-rgvaAL-----------LAP 72 
WP_016332152         13 AALasdarvP--VLLLPVGAVEPHGPHAPLGTDPLISRGMCER----A-----AarlagdpglrVL-----------ILP 70  Amycolat...
CHGC:AMES_6860       13 ASLpddervP--VLLLPVGAIEPHGPHAPLGTDPLISRGMCER----A-----AerlaadddvhVL-----------VLP 70 
goetting:Awo_c33050  14 AQCnk--ekT--IVFIGFAPIEEHGRHLPLGVDVYETQYWMDNslskLEVEfgeh-------------------tflTMP 70 
WP_013969230         13 EKMpr--seT--VFFQVIAPVEEHSHHLPLGTDIFLGETWAKKainiLEKNkpnl-------------------nciMMP 69  Treponem...
goetting:Awo_c31990  19 EAAik--qnA--CVLLPVSVVEEHGPHLCTGTDIYLTQSLSQQ---------------------IKqklvaknhpvvIAP 73 
CCY44498             15 CQVlr--ekS--IAYLPVGPLEWHGPAMPYGTDAMAAGESARR----TAMItgGa----------------------VVP 64 
3NO4_A               81 TINVGX-A---LHH-TA---FPGT--------------ISLRPSTLIQVVRDYVTCLAKAGFSKFYFINGHGG--NIaTL 136
jgi:Sthe_1012        74 PLPYGA-S---FIA-TC---FPGT--------------SPAEPDAFRAYLTSVLLNLLPQGYRCICICNAHREpaHAeAV 131
jgi:Hoch_5093        70 PLAYTA-A---GFA-AG---FAGT--------------LAMRPETVTAMVVDIGRGLAAHGFGLLAIANAHLDptHIgSL 127
CAN92153             73 PIGYGV-T---DFA-AG---FAGA--------------ISIPAPALTAFLRAVAEAYLSAGLSHVCFINNHLEpeHDrAV 130
WP_016332152         71 EVPYGV-T---RFA-AG---FAGG--------------VSIGEETLYALLTEICGALTEQGLTRILLVNNHFEpaHLaVL 128 Amycolat...
CHGC:AMES_6860       71 EVPYGV-T---RFA-AG---FAGG--------------IHIGEETLHSLLVDIGAALIAQRLGRILLVNNHFEpaHLvTL 128
goetting:Awo_c33050  71 VITYGH---------ASmkgLPGN--------------IHLSQQLLYELVLVTVDNILEWGIKNIVIISGHADpkHTiAI 127
WP_013969230         70 ILPVAA---------GSmkgFPGC--------------LYQRAKDVRKVLYSVLQNLAQFGFQNIIVVASHGDpmHQiCV 126 Treponem...
goetting:Awo_c31990  74 PFYWGV-N-------SItdgFVGS--------------FSIKPETMTLMLLEILENLNKWGFKKIFLLNFHGDfiHIkTI 131
CCY44498             65 TMFMGTeTprdNEFlQTaglQPNTyvvgmdfpknsipsMYLRAELFAVMLREQVRLLVNLGFKLIVIVNGHGAvaQEeAI 144
3NO4_A              137 KAAFSETYAHL---EDLqiana----------------qqvqcQVANWFXCGSVYKLAK-------ELYGDQEg--SHAT 188
jgi:Sthe_1012       132 WASARAAA------AATg-------------------------VPAVFPDVRDSRWASV-------LGDEFRSr-pRHAG 172
jgi:Hoch_5093       128 KRAGEELAd-----SGVt-------------------------IGFAFPDVTRKPWALR-------LSDEFRSg-aCHAG 169
CAN92153            131 RAATSDLPLGr---ASVa-------------------------CPLA------RRWART-------LSAEFRSg-aCHAG 168
WP_016332152        129 RRVAET--------AG-----------------------------VGFVDLVRRRYAAR-------LTDEFRSg-eCHAG 163 Amycolat...
CHGC:AMES_6860      129 RRAAETLNFAYd--GR-----------------------------VALLELVRRRHAER-------LTDEFRSg-eCHAG 169
goetting:Awo_c33050 128 EQVCEKVNNENgivAFApmgaifsgevaia-denqdpdmkqkmMAFPn---------------------------dFHAG 179
WP_013969230        127 EKACEMINSKYgdvAISplgsivfsgkrpknganlsseleillKKYKf---------------------------dFHAG 179 Treponem...
goetting:Awo_c31990 132 VEIVAHANKMN---IEAyfl--------------------ldkNLLSQMHFNQDLSYLVsieldprKVNLETTvidIHAG 188
CCY44498            145 HRIAKETTAETdstVIGvrat------------------yalkEGDLn---------------------------gGHGS 179
3NO4_A              189 PSEVALTQYVYPEAIKQAPL-----SPEVAsgh--riYSAADFRVRY-PDG---RX---Gs----------NPGLATPEH 244
jgi:Sthe_1012       173 RAETSIMLAAQPGAVLHDGMahlpeVPIDLp-----aRLRKGARTLS-EAGgtlGYf--G-----------DPARANAAE 233
jgi:Hoch_5093       170 QYEGSMVLAERPELVREELRaqlapNPASLs-----vAIRAGHTSFE-EAGgprAYf--G-----------DPAAATADE 230
CAN92153            169 RYETSLVLAAASALVRKDIAealpdLGLSLs-----eGIKAGAKSFR-ALGmdaAYt--G-----------SPREASEDE 229
WP_016332152        164 QYETSLVLADRPDLVDATVQralpaVHVDL--------ARGGVTDFA-SAGmteAYc--G-----------TPAQATAEE 221 Amycolat...
CHGC:AMES_6860      170 RYETSLVLADRPELVDQTLMrtlphVPVSL-------AAAPADGGFR-EMGmtdAYc--G-----------KPAEATARE 228
goetting:Awo_c33050 180 WIETSNMLEIRKDLVKHDFIkqpdiVVSDKe-----mINPEVVMKKTaGYG---HL---G-----------YPKEASVAL 237
WP_013969230        180 WVETSMIMAEKQELIKSDILsmpdiEVTDRe-----mINPSVYLKKTaEWG---HL---G-----------YPKLSNPEL 237 Treponem...
goetting:Awo_c31990 189 ATETSWMALSYNKLVDTEKAktlkpTNLTRsdlkewlKGGEVAKSVT-PLG---YC---G-----------NPSNIDL-- 248
CCY44498            180 VKETAVQMYLNGGSVDLSKFppreeP---------------LRMP---DYG---ILnlfGphfpkdmimdpDPRDATAEL 238
3NO4_A              245 GKQFYDLAVKELS 257
jgi:Sthe_1012       234 GERLLASLAGivr 246
jgi:Hoch_5093       231 GQATIATLGEILE 243
CAN92153            230 GRALLDLLATMIV 242
WP_016332152        222 GEKTFSVLTDILV 234 Amycolatopsis keratiniphila
CHGC:AMES_6860      229 GEETFSTLTDLLV 241
goetting:Awo_c33050 238 GKTLNHSVIEKIr 250
WP_013969230        238 GNELNNITSSDla 250 Treponema caldarium
goetting:Awo_c31990 249 --KKIKTLTAVLS 259
CCY44498            239 GKQYLEHGAEKNA 251
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