3NO4


Conserved Protein Domain Family
Creatininase

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pfam02633: Creatininase 
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Creatinine amidohydrolase
Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.
Statistics
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PSSM-Id: 335018
View PSSM: pfam02633
Aligned: 448 rows
Threshold Bit Score: 85.6242
Threshold Setting Gi: 503873257
Created: 17-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO4_A        31 EAYLQQSKGIIFPIGSTEQHGPTGLIGTDAICAEAIAAGV-----GDatgAIVGP-----TINVGXALHH-TA---FPGT 96
gi 505823928  24 GEAVKRAPIAVLAFGSVENHSTHLPLSADTLQGTELIKRAaekltEK-----GLPalpafCVPYGV-ETNrFErqnTLGN 97
gi 504037704  12 EEYFTKSDMVIIPIGSIECHGRHMPLGTDTMIPDKILSLVeq-qtDR---ILIAP-----TIPYGACESL-WP---FPGT 78
gi 503017678  12 EKYFKESDLVIIPIGSIECHGKHMPLGTDTLIPDKIIELLrr-qeDR---FLIAP-----TIPYGACESL-YP---FPGT 78
gi 505823938  12 ETYFKTHDTVLLTVGSIECHGRHLPLGTDTMIPNRILELLee-knKD---ILIVP-----TIPFGSCDSL-EP---FPGT 78
gi 547793399  12 ERYFKENDMVILPIGSTECHGRHMPLGTDTLIPDKILDLIeek----ndnILIAP-----MIPYGAC----QSladYPGT 78
gi 291563441  12 QEYFEKNDMVLVSIGSIECHGRHMPLGTDTLIPNHLLEKIek--kSD---VLIAP-----TIPYGSTPGL-AP---YPGS 77
gi 514048683  12 NDYLKEHDSIMLVLGSTENHGRHMPLGTDTMIPDKIAELTek--qSH---IMIAP-----TLPYGATDSL-MG---FPGT 77
gi 524511719  12 EGYFKEKDIAIIPVGSTENHGSQLCLGTDFLIPRRLCEMMder-----lnILIAP-----TVPFGVGDQH-IN---FPGT 77
gi 503757634  13 GKL-DRAIPVIVPLGLVEAHGPHLATSVDIDTANYFSRKV-----AEntgAILAP-----CVNYGFA----DEmrdYPGT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO4_A        97 ISLRPSTLIQVVRDYVTCLAKAGFSKFYFINGHGGNIATLKAAFSetyahledlqianaqqvqcqvanwfxcgsvyklak 176
gi 505823928  98 VSLSQKTFIQMVTELSLSLVKNGFKRLVFCVSHTENLAAMHVAAKdlgdehdvpvivvnwip----------pmndewpk 167
gi 504037704  79 INLGNDLLYQLVKQIVLNLRRHGARKFLVVNGHGGNIKALERIGYeldsegcmmallnw----------------wqnvw 142
gi 503017678  79 VNLGTDLLYELMKTIVENLKRHGAKKFVVLNGHGGNIKALERIGYeldadgclmailnw----------------wlnvw 142
gi 505823938  79 INLGVDLLYQLLRRIVDSLKLHGARKFIFLNGHGGNVRTIEKLGIeldkegcllsllnw----------------wlnvw 142
gi 547793399  79 IDIDSDILYQYVYQIVDGLYKHGARKILVLNGHGGNIKTIERIGLefdkkgamvvmlnw----------------wlmaw 142
gi 291563441  78 IDIDSEVLYQFCRQVFLSLYRHGARKFVFLNGHGGNIKMIQRLGMefedkdclvamlnw----------------wmmaw 141
gi 514048683  78 ISIGVDGLYDILTRITDSLYEYGFRRFIILNGHGGNSKSIEMLGKrmhprgayvaclnw----------------wlmag 141
gi 524511719  78 ITIGYDGLYDLMTRIVDQLYGFGIRKFVFLNGHGGNTPVLQRVALelderhamgailnw----------------wllag 141
gi 503757634  78 LGVTVETFMAIVQDLIQRFYKTGFKKIVFITGHGANKTACELAFFkiweahpdfkgvc------------------wnww 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO4_A       177 elygdqegSHATPSEVALTQY------VYPEAIKQAPl-SP------------------EVASGHRIYSAADFRVRY-PD 230
gi 505823928 168 flknaahqGHGGEDETACVMA------VTPHLVDIS------------------------------------------NS 199
gi 504037704 143 emnplwkgGHGGGEETAAIMA------IDPSLVDTSQieLPlelkdvsat-ikasgfntVKYKEVTLTIPRLTNHVT-TN 214
gi 503017678 143 emnpewkgGHGGGEETAAVMA------IDPDLVDRSYidLPleitdlsdt-ikgsgfntVQYDNITVTIPRLTNHVT-SN 214
gi 505823938 143 emdpawkgGHGGGEETAGIMG------IDPSLVDMNEinKDmilkdvspa-fkatgfntVEYKGIQVTIPRLTNHVT-DN 214
gi 547793399 143 dmkpewkgGHGGGEETAGIMA------VDPSLVDMSQidLPlemtnltdn-lvatgfrtVRFKGVEIEILRNTPKVT-DN 214
gi 291563441 142 dmnpawkgGHGGGEETAAILG------IDPSLVDKSEigGElqfkhlsdn-lkttgfrsVEYKGVTVEIPRKTPHVT-DN 213
gi 514048683 142 elnpdwagGHGGAEETAGVMA------VDPSLIDYDHidEPlimqsdvyetmpstgwdkVSFMGATVVIPRRAMNYN-AN 214
gi 524511719 142 eldprwkgGHGGGEETAAMLA------IDPSCVHMEYfmPFepkdlspd--ltfagsfnVNCNGVSVPVPRHVDRYS-SC 212
gi 503757634 140 sdcgitgiHHADKGETEVAMAvgtpskM--EAVRDFEvnKPwykia------------------------sryelDPdSG 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
3NO4_A       231 GRX------------------------------------GsNPGLATPEHGKQFYDLAVKELS 257
gi 505823928 200 GSYhppedtnpvksaglhyyggalgiytpigadktpgfvG-DPSDADAKAGEICYDLYADWIA 261
gi 504037704 215 GWIg----------------------------------sD-HPKYATEAWGTEMLQAMADYIV 242
gi 503017678 215 GWIg----------------------------------pD-HPKYATVEWGSEMLQTFTNFMV 242
gi 505823938 215 GWIg----------------------------------pD-HPNTATEEWGKKMLQAMADYLA 242
gi 547793399 215 GWIg----------------------------------pD-HPNTATVEWGQEMVQTTANYIL 242
gi 291563441 214 GWIg----------------------------------pD-HPSTATEEWGKEMLETTANYIV 241
gi 514048683 215 GWYg----------------------------------tD-APNKATKEWGDRMVQTMADYAA 242
gi 524511719 213 GWYg----------------------------------pD-SPETATKEWGEEMLKATADFCV 240
gi 503757634 194 GIN------------------------------------G-KPSLADIENGNKICDKAVEALT 219
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