6BK5


Conserved Protein Domain Family
Cbl_N
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pfam02262: Cbl_N 
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CBL proto-oncogene N-terminal domain 1
Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.
Links
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Statistics
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PSSM-Id: 426685
Aligned: 29 rows
Threshold Bit Score: 150.825
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BK5_A        36 VDARTTSRIEKATRKLLT-LCSNKRlkLKNSPPYLQGILFDTNDFFRRIFSLN-------TLDT------LRDCPYLNLA 101 Salpingoeca ros...
XP_015224249   7 LDRRTLDKVGRRLQRLQK-LCENPRlgLRNSPPYLPELVPDTLGHLRLVWGSRg-----gAAAA------SDEAEYLGLL 74  spotted gar
XP_007491645  15 KEQKSLARAIRALEHLEHaLGQDPH--LEPSPPSLADLLPQMRGLLRQVAEAQr-----lAQGGlh--epGGASDFLAGY 85  gray short-tail...
EDL23196      13 GEPRALSRAVKLLQRLEE-QCRDPR--MVTGPPSLRDLLPRTAQLLGEVAKARre----aREDPeg---pGGADDFLAIY 82  house mouse
XP_013002334  13 AEQRALGRAVRLLQSLEE-QCGDPR--LAMGPPSLRDLLPSTVRLLRAVARVRhdagpggSEGP------GGAWNFLQVF 83  domestic guinea...
XP_023398927  14 GDARALGRVVKLLERLEA-HCGDPR--LASSPPSLRDLLPRTAQLLRKVTLARra---egGRCLev---pGGAWDFLAIY 84  African savanna...
NP_001121724  30 ADRKLLEKVLKRLDKLHK-LSVDPRlaLKNSPPYLPELLSETAIHLTEVWAPYr-----gSAMAvp---rWDEGDYMRIH 100 zebrafish
XP_007249631  29 ADRKLLEKALKKLSKLHT-LCTDSRlgLKNSPPYLPDLVSETVILLTEVWDPYr-----gPAPAvp---rGDEADFLKIH 99  Mexican tetra
XP_005463987  22 GDLRLVDKTLRRLDKLQQ-LCSTPRlgLRNSPPYLPQLVSETSALLIQVWEPFq-----dFRAAgeqvphGDEAEYLRIH 95  Nile tilapia
1_pfamImport   1 GDRLLVDKLLKRLVKLRH-LCANARlgLRLSPPYLPELVSDTAALLTQVWEPYr-----gPGAAggraprGDEAEYLRVH 74 

6BK5_A       102 VRKYLIHCRIATKLF-----RDAGEEMESEDSEYRRQLNKYTLVFSHMLADLQAVYKDGHLD 158 Salpingoeca rosetta
XP_015224249  75 LRHLLDKADRAVLLF-----KDGREKMFDENSSHRRNLTKLSLIFSHMLSELRSLFPGGHFQ 131 spotted gar
XP_007491645  86 LSNLAQKGQQLAALF-----PAGS-KAFWEGSSRRRKLTKLSLIFSHMHTELRALFPDGHYC 141 gray short-tailed opossum
EDL23196      83 LANLEVKGRQVAELLpprgkKDVNQDVFREGSRFRRQLAKLALIFSHMHAELSALFPAGKYC 144 house mouse
XP_013002334  84 LANLEAKAKQVAGLLpgrgrRGASDDLFLEGSRLRQQLAKLALIFSHMHAELGALFPKGKYC 145 domestic guinea pig
XP_023398927  85 LANLEAKGRQVAMLLpprgrTEANDELFREGSRLRRQLAKLALIFSHMHAELDALFPGGQYC 146 African savanna elephant
NP_001121724 101 IRHLLDKTDRAVLLF-----KEGKEKMFEETSNYRRNLTKLSLLFSHMLNELRTIFPGGRFQ 157 zebrafish
XP_007249631 100 VRHLLDKTNRAILLF-----KEGKDKMFEERSSYRRNLTKLSLLFSHMLWELRAMFPDGRFQ 156 Mexican tetra
XP_005463987  96 IKNLFDKTERAVLLF-----KEGRRKIYEETSTYRRNLTKLTLLFSHMLWELKAFFPGGCFQ 152 Nile tilapia
1_pfamImport  75 ARNLLDKTERALLLF-----KEGREKMFDETSSCRRNLTKLSLLFSHMLWELRAVFPGGGFQ 131
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