6BK5


Conserved Protein Domain Family
Cbl_N

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pfam02262: Cbl_N (485634 is an unknown moldel)
CBL proto-oncogene N-terminal domain 1
Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.
Statistics
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PSSM-Id: 485634
Aligned: 26 rows
Threshold Bit Score: 151.236
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BK5_A         36 VDARTTSRIEKATRKLLTLCSNKRlkLKNSPPYLQGILFDTNDFFRRIFSLN--TLDT------LRDCPYLNLAVRKYLI 107 Salpingoeca ro...
XP_004364071   71 LDSRTLDRLSSRVQKILKLIKSKKltLRNSPPFLQELLAEIYQHLKLILSKA--ELET------LRQIPYLTITLQNIFL 142
XP_001745549   40 IDTKTLLRIDKNTERLITLCQNPRlnLKNSPPFLQGILFDTREHLHALFERN--PLEA------LRQNAFVSIFLIKFLS 111
8_pfamImport    1 KERQMVDKSLKKLDRLHNLCTNPRlgLKNSPPYLPDLVRETLTLLHQVWEPYlgYSSAggqfprGDEATYLGVHVRNLLD 80 
XP_009024674   59 VDKKSIEKSWKLMDKVVKLCQQPKmnLKNSPPFILDILPDTYQHLKQISLKYedKMST------LNDIEYFRIFLDNLIT 132
1_pfamImport    1 SDRKTFDKLYKLMDLVIKACNTPKlnLKNSPPFILDIIPDTFTQLIAIFTR---DPNV------MRSNEYMGLFMSNAQL 71 
Q19019         64 EDRRFLLKACKFMDQVVKSCHSPRlnLKNSPPFILDILPDTYTHLMLIFTQ---NNDI------LQDNDYLKIFLESMIN 134 Caenorhabditis...
13_pfamImport   1 IDKRTVEKTWKLMNKVVKLCNNPKiiLKNSPPFILDILPDTYQHLRLIYNKYedRMNY------LNENEYFRVYIDNLNK 74 
XP_001967682   33 TDKKTLEKTWKLMDKVVKLCQQPKmnLKNSPPFILDILPDTYQRLRLIYSKNedQMHL------LHANEHFNVFINNLMR 106
3_pfamImport    1 IDKKYIEKSSKLMDKVAKFCQQSKmnLKNSPPYILDILPDTYNHLRLIMLRYedRLQV------LNECEYFRIFLDNLIK 74 
6BK5_A        108 HCRIATKLFRDAG-EEMESEDSEYRRQLNKYTLVFSHMLADLQAVYKDGHLD 158 Salpingoeca rosetta
XP_004364071  143 KLYNISSLIKKGKhEDLQQEESHIRRQLTKFTLILSHIVTDFKAVFPNGKFC 194
XP_001745549  112 HCKRASNLFKEAG-DRMEDEQSEDRRELNRLTLVFSHMLADFKSLTQDAKLD 162
8_pfamImport   81 KTEKAMLLFKDGR-EKIFDETSSCRRNLTKLSLLFSHMLWELKAMFPGGHFQ 131
XP_009024674  133 KCKKCLKLFKDSK-EKIFEEHSEYRRSLTMLSLMFSHMLAELKALFPSGVFA 183
1_pfamImport   72 KCKEVLKLFKSSA---IYNDESHERRKLTKLSLVFSHMLSELRAFFQNGEFV 120
Q19019        135 KCKEIIKLFKTSA---IYNDQSEERRKLTKMSLTFSHMLFEIKALFPEGIYI 183 Caenorhabditis elegans
13_pfamImport  75 KCKETIRLFKEGK-DAMFDETGPCRRNLTKQSLVFSHMLSELKAIFPDGLFA 125
XP_001967682  107 KCKQAIKLFKEGK-EKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFA 157
3_pfamImport   75 KCKEAIKLFREGR-ERMFDENSQQRRSLTKLSLVFSHMLAELKAEFPDGRFI 125
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