2O3A


Conserved Protein Domain Family
Trm56
?
pfam01994: Trm56 
Click on image for an interactive view with Cn3D
tRNA ribose 2'-O-methyltransferase, aTrm56
This family is an aTrm56 that catalyzes the 2'-O-methylation of the cytidine residue in archaeal tRNA, using S-adenosyl-L-methionine. Biochemical assays showed that aTrm56 forms a dimer and prefers the L-shaped tRNA to the lambda form as its substrate. aTrm56 consists of the SPOUT domain, which contains the characteriztic deep trefoil knot for AdoMet binding, and a unique C-terminal beta-hairpin.
Links
?
Statistics
?
PSSM-Id: 426555
Aligned: 81 rows
Threshold Bit Score: 169.564
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2O3A_B          56 WGGDFFIK-AVSWKKLLREFD---GLKVHLTMYGIPLPQKLEEIKRADK-----VLVVVGAEKVPPEVYELCDLNISIGT 126 Archaeoglobus...
Q5V3R4          58 FGGPFDVAsTEEPKRLIRDFE---GRVVHLTMYGEPVQEVEADVREANTae--pLLVVVGAEKVPFEVYEHADWNVGVTN 132 Haloarcula ma...
jgi:Halru_1278  58 FGGPFTAElVEKPAAVVRNWE---GPIAHLTMYGEPVQTVESEIRSTVTegddpLLVVVGAEKVPFEMYEQADWNVGVTN 134
ERJ07731        58 FGGPFEVEiTDSPLGRLRSWK---GPIVHLTMYGQPVQRVEDEIRASHRee--pLLVVVGAEKVPFEVYDRADWNLGVTN 132
WP_020446738    58 FGGPFAVEsTERTISILEEWE---GSIAHLTMYGEPVQTVEEEVRTAHRee--pLLVVVGAEKVPWDVYEHADWNLGVTN 132 Salinarchaeum...
O27185          55 WGGPFSVVyRRNWQGVIDSWKkdgGEVIHLTMYGLPARDVVPGIMDNGKd----KLIVVGGARVPGKVYSLADYNVGVTN 130 Methanothermo...
CDG65734        55 WGGNFQVEyCKKWGNLLEEWKdkgGEIVHLTMYGEQVQDVTPQIRSSPRd----KLVVVGGSRVPSKVYQEADWNVSVTT 130
Q2NF55          54 WGGDFEVEyQKAYRPVIKEHKqkgFEIIHLTMYGKHVEDVVPTIRDNNRd----KLIIVGGSRVPTDVYEAADWNLSVTN 129 Methanosphaer...
agres:mru_1893  55 WGGDFEIEyNNSYMEVIMNWRekgGKIVHLTMYGAQAHEVVDEVRESSDd----ILIIVGGAKVPTKVYKNADWNVSVTT 130
jgi:Mfer_0122   54 WGGPFSIEyCKNWRKVIKNWKskgGEVIHLTMYGLPVQKVIDKLKN-DKd----KLIVVGSSKVPGEVFELADWNVAVTN 128

2O3A_B         127 QPHSEVAALAVFLDRVL-GKVFDISFDDAKIKVIPSERGKRVV 168 Archaeoglobus fulgidus
Q5V3R4         133 QPHSEVASLAVFLDRLFeGRELDREWENPDRVVVPQETGKRVV 175 Haloarcula marismortui ATCC 43049
jgi:Halru_1278 135 QPHSEIAGLAVFLDRLFdGDELDREWVDASRKVVPKETGKLVL 177
ERJ07731       133 QPHSEIAALAVFLDHLFdGRELDREWTDAEKRVIPKETGKRVE 175
WP_020446738   133 QPHSEVAALAVFLDRLFeGQELDREWDDAERAVVPKAEGKLVE 175 Salinarchaeum sp. Harcht-Bsk1
O27185         131 QPHSEVSSLAVFMHMLLdGAEFDLKFEDARIEVIPQARGKMLR 173 Methanothermobacter thermautotrophicus str. Delta H
CDG65734       131 QPHSEVSALAIFLHMLYdGKELDLEFENGDMKVIPSARGKNVV 173
Q2NF55         130 QPHSEVAALAICLHYMMdGSELKTVYDDGKMQIVPNNEHKEVI 172 Methanosphaera stadtmanae DSM 3091
agres:mru_1893 131 QPHSEVAALAIFQHLLMeGKEFDLEFKDPVFEVIPTAHGKTVN 173
jgi:Mfer_0122  129 QPHSEVSSLAVFLHMFFeGSELEKKFKNAKIKIIPSKKGKKII 171
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap