1OFE


Conserved Protein Domain Family
Glu_synthase
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pfam01645: Glu_synthase 
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Conserved region in glutamate synthase
This family represents a region of the glutamate synthase protein. This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organizms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster.
Links
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Statistics
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PSSM-Id: 396287
Aligned: 13 rows
Threshold Bit Score: 493.003
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1OFE_A    798 SPEMSKSLHKAVAAykvggngnngEAYDHYELYRQYLKDR-PVTALRDLLDFNADQPA-----------ISLEEVESVES 865  Synechocystis sp....
CBS88067  832 EGGIIHTLQQAVTN----------DSYTTFKKYSEQVNKR-PPMQLRDLLEFRTTKAA-----------VPVDEVESITS 889 
P39812    802 NPKTIHTLQWACRR----------NDYNLFKQYTKAADEE-RIGFLRNLFAFDGNRKP-----------LKLEEVESAES 859  Bacillus subtilis...
Q12680    872 EPTAIASLQDTVRN----------KNDVSWQLYVKKEMEAiRDCTLRGLLELDFENSVs----------IPLEQVEPWTE 931  Saccharomyces cer...
Q8ILB1   1084 HPETISLLQKATRS----------GNKDTYKKYSELQNELiNHCEIRGQLEINYKKCPsynkikkkhepINIHLVEPVNK 1153 Plasmodium falcip...
Q9ZNZ7    909 NPEMSKLLHKAVRE----------KSETAYAVYQQHLSNR-PVNVLRDLLEFKSDRAP-----------IPVGKVEPAVA 966  thale cress
P09831    796 NPDVVRTLQQAVQS----------GEYSDYQEYAKLVNER-PATTLRDLLAITPGENA-----------VNIADVEPASE 853  Escherichia coli ...
O34849    118 EMHVNQTPKIETQI-----------YKMDADNLFKRKEHAeHIKADPYFLHPDDVQVIg------------EHTCEKPFY 174  Bacillus subtilis...
Q58746    107 PIYFDKIVLDACQV-----------TNPSIDPLREPMELRtYIGKKPKQLEFEFVEEEidgkk--ikkaKLKTKIAPNLK 173  Methanocaldococcu...
O29309    114 RIYWDHIVLNASQV-----------TNPSIDPLREPMELRtFLGRKQDRLEFKYSEDFed--------iEITTELYPNVQ 174  Archaeoglobus ful...
O26208    250 PN-FDDIIILPAQA-----------SIPPVDKYREPCNTSvVLGDR-------FAEEPl--------------------v 290  Methanothermobact...
O26296    121 PT-FDDLVIIPAQV-----------SRPPIDKYREPCNTRvVIGDR-------YAENPl--------------------e 161  Methanothermobact...
O27702     15 KIVQIKRIAHSGEVp--------vESMGSEKRLPLGLDDLhFLPAQVSKIPL-NAEDPvkt-----dviIGPESKRP-LR 79   Methanothermobact...

1OFE_A    866 IVKRFCTGGMSLGALSREAHETLAIAMNRLG-AKSNSGEGGEDVVRYLTLDDVdsegnsptlphlhglqngdtansAIKQ 944  Synechocystis sp....
CBS88067  890 IRKRFITPGMSMGALSPEAHGTLNVAMNRIG-AKSDSGEGGEDPARFRPDKNGdnw------------------nsAIKQ 950 
P39812    860 IVKRFKTGAMSFGSLSKEAHEALAIAMNRLG-GKSNSGEGGEDPKRFVPDENGddr------------------rsAIKQ 920  Bacillus subtilis...
Q12680    932 IARRFASGAMSYGSISMEAHSTLAIAMNRLG-AKSNCGEGGEDAERSAVQENGdtm------------------rsAIKQ 992  Saccharomyces cer...
Q8ILB1   1154 ILLRFCTGAMSFGSLSEEAHTTVATAMNSMG-LKSNTGEGGEAEERIKTANNEint------------------nsAVKQ 1214 Plasmodium falcip...
Q9ZNZ7    967 IVQRFCTGGMSLGAISRETHEAIAIAMNRIG-GKSNSGEGGEDPIRWKPLTDVvdgysptlphl-kglqngdiatsAIKQ 1044 thale cress
P09831    854 LFKRFDTAAMSIGALSPEAHEALAEAMNSIG-GNSNSGEGGEDPARYGTNKVS-----------------------RIKQ 909  Escherichia coli ...
O34849    175 VKGLVGQSAMSYGSLGERAVTALSKGLHLAGgTWMNTGEGGLSEYHLKGGADI------------------------ICQ 230  Bacillus subtilis...
Q58746    174 LDTPIMIAHMSYGALSLNAHLSFAKAVKECG-TFMGTGEGGLPKALYPYADHI------------------------ITQ 228  Methanocaldococcu...
O29309    175 IETPIVFSAMSYGAISYQAFKSLAMAASEFG-TLFNTGEGGLPKELRKYGKNA------------------------IVQ 229  Archaeoglobus ful...
O26208    291 LQTPVLIAGMSFGALSKESKLAMAKGSSMVG-SCANTGEGGMLPEERELADNL------------------------MVQ 345  Methanothermobact...
O26296    162 LDTPIMIAAMSFGALSKEAKIALAMGASLAG-TATNTGEGGMLPEERRYASKL------------------------IAQ 216  Methanothermobact...
O27702     80 LKSPIIISGMSYGAVSEKTRIAIASVADRLK-IGFNSGEGGVLQRELEKAGDY-----------------------LIIQ 135  Methanothermobact...

1OFE_A    945 IASGRFGVT-------------PEYLMSGKQLEIKMAQGAKPGEGGQLPGKKVSEYIAMLRRSKPGVTLISPPPHHDIYS 1011 Synechocystis sp....
CBS88067  951 VASGRFGVT-------------AEYLNQCRELEIKVAQGAKPGEGGQLPGFKVTEMIARLRHSTPGVMLISPPPHHDIYS 1017
P39812    921 IASGRFGVK-------------SHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTPGVGLISPPPHHDIYS 987  Bacillus subtilis...
Q12680    993 VASARFGVT-------------SYYLSDADEIQIKIAQGAKPGEGGELPAHKVSKDIAKTRHSTPNVGLISPPPHHDIYS 1059 Saccharomyces cer...
Q8ILB1   1215 IASARFGVT-------------AYSLVNAQELQIKVAQGSKPGEGGELPGYKVSSKIASIRRSTPGVGLISPPPHHDMYS 1281 Plasmodium falcip...
Q9ZNZ7   1045 VASGRFGVT-------------PTFLVNADQLEIKVAQGAKPGEGGQLPGKKVSAYIARLRSSKPGVPLISPPPHHDIYS 1111 thale cress
P09831    910 VASGRFGVT-------------PAYLVNADVIQIKVAQGAKPGEGGQLPGDKVTPYIAKLRYSVPGVTLISPPPHHDIYS 976  Escherichia coli ...
O34849    231 IGPGLFGVRkrngefsweefkrKSRIDQIKAFELKLAQGAKTR-GGHVDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSN 309  Bacillus subtilis...
Q58746    229 VASGRFGVN-------------EEYLMKGSAIEIKIGQGAKPGIGGHLPGEKVTAEISATRMIPEGSDAISPAPHHDIYS 295  Methanocaldococcu...
O29309    230 CASGRFGVD-------------PEYLNVAAVVEIKIGQGAKPGIGGHLPGEKVTLPISVTRMIPEGTDALSPAPQHDIYS 296  Archaeoglobus ful...
O26208    346 YSSGRFGVS-------------SDYLNVADAIEVKIGQGAKPGMGGHLLAEKVSPEVAKIRGIPEGTDALSPARFLDATR 412  Methanothermobact...
O26296    217 YASGRFGVS-------------AEYLNNSEAIEIKIGQGAKSGMGGHLLAEKVTAEVSRIRMIPEGTDALSPARHMDIVG 283  Methanothermobact...
O27702    136 YSTGRFGIT-------------EDVLRGAAAIEIRFGQGAYPGKGSYLPPDKISPDVARVRGLAPGEGSYSPAHHHDIRD 202  Methanothermobact...

1OFE_A   1012 IEDLAQLIYDLHQIN-PEAQVSVKLVAEIGIGTIAAG----VAKANADIIQISGHDGGTGASPLSSIKHAGSPWELGVTE 1086 Synechocystis sp....
CBS88067 1018 IEDLAQLIYDLKQIN-PDAKVTVKLVSRSGIGTIAAG----VAKANADIILISGNSGGTGASPQTSIKFAGLPWEMGLSE 1092
P39812    988 IEDLAQLIHDLKNAN-RDARISVKLVSKAGVGTIAAG----VAKATADVIVISGYDGGTGASPKTSIKHTGLPWELGLAE 1062 Bacillus subtilis...
Q12680   1060 IEDLKQLIYDLKCAN-PRAGISVKLVSEVGVGIVASG----VAKAKADHILVSGHDGGTGAARWTSVKYAGLPWELGLAE 1134 Saccharomyces cer...
Q8ILB1   1282 IEDVGQLVYDLKNIN-KEAKISVKLVSKLGIGVITSG----VVKGNCEQILISGTSGGTGASKWTSIKHAGLPWEIGLAE 1356 Plasmodium falcip...
Q9ZNZ7   1112 IEDLAQLIFDLHQIN-PNAKVSVKLVAEAGIGTVASG----VAKGNADIIQISGHDGGTGASPISSIKHAGGPWELGLTE 1186 thale cress
P09831    977 IEDLAQLIFDLKQVN-PKAMISVKLVSEPGVGTIATG----VAKAYADLITIAGYDGGTGASPLSSVKYAGCPWELGLVE 1051 Escherichia coli ...
O34849    310 PPEMLDFIEKLRDVG--QKPVGIKLVAGHPEELHELFshmqKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPI 387  Bacillus subtilis...
Q58746    296 IEDLAQLVRSLKEATrWKKPVFVKIAAVHNAPAIAVG----IATSDADAVVIDGYKGGTGAAPKVFRDHVGIPIEMAIAA 371  Methanocaldococcu...
O29309    297 IEDLSMLIYALKEATnYEKPVSVKIAAVHNVAAIASG----MVRAGADIIAIDGLRGGTGAAPKMIRDNVGIPVELALAA 372  Archaeoglobus ful...
O26208    413 EGDLAKHIELLREVTdWRVPIVVKLGPGRVYEDVQI-----AAEAGADVISVDGMEGGTGAAPEVVIEHTGVPTLAALVQ 487  Methanothermobact...
O26296    284 PEDLSMKISQLREITdWKVPIMVKFTSGRVADDVKI-----AAKAGADAVVVDGMQGGTGAGPDVVTEHSGIPTIAAIVE 358  Methanothermobact...
O27702    203 QMELEEKVKELRKMS-GGAPIGAKIGCGNVEDDVKA-----LLDAGVDFISLDGFGGGTGAVNPHIRDNTGIPLIAAIPR 276  Methanothermobact...

1OFE_A   1087 VHRVLMENQLRDRVLLRADGGLKTGWDVVMAALMGAEEYGFGSIAMIAEGCIMARVCHTNNCPVGVATQQERLR--QRFK 1164 Synechocystis sp....
CBS88067 1093 VHQVLTLNKLRHRVRLRTDGGLKTGRDIVIAAMLGAEEFGIGTASLIAMGCIMVRQCHSNTCPVGVCVQDEKLR--EKFV 1170
P39812   1063 AHQTLMLNGLRDRVVLETDGKLMTGRDVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELR--KKFM 1140 Bacillus subtilis...
Q12680   1135 THQTLVLNDLRRNVVVQTDGQLRTGFDIAVAVLLGAESFTLATVPLIAMGCVMLRRCHLNSCAVGIATQDPYLR--SKFK 1212 Saccharomyces cer...
Q8ILB1   1357 AHQTLCKSKLRKRVILQIDGQLKTGRDVILGALLGAESFSFSTQPLISLGCIMMRKCHLNICPVGICTQDPELR--KKFA 1434 Plasmodium falcip...
Q9ZNZ7   1187 THQTLIANGLRERVILRVDGGLKSGVDVLMAAAMGADEYGFGSLAMIATGCVMARICHTNNCPVGVASQREELR--ARFP 1264 thale cress
P09831   1052 TQQALVANGLRHKIRLQVDGGLKTGVDIIKAAILGAESFGFGTGPMVALGCKYLRICHLNNCATGVATQDDKLRk-NHYH 1130 Escherichia coli ...
O34849    388 VDTLLKQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCPAGVATTDPKLQkaLSVE 467  Bacillus subtilis...
Q58746    372 VDQRLREEGLRNEISIIASGGIRCSADVFKAIALGADAVYIGTAAMVALGCRVCGRCYTGLCAWGIATQRPELVkrLDPE 451  Methanocaldococcu...
O29309    373 VDQRLRDEGIRNKASILVAGGFRCSADVVKAIALGADAVYIGTPALVAMGCTLCQKCHTGICNWGICTQDPYLAkrLNPE 452  Archaeoglobus ful...
O26208    488 AVNGLNDIGLKDEVDLIITGGIRSGADVAKAMAMGADAVYIGTGAMIAMGCRACRMCYTGKCPVGVATQDPVLRerMDVD 567  Methanothermobact...
O26296    359 ADEALKEVNLRDEVSLIAAGGIRSGADVAKAIALGADAVYIGTAALVSIGCRVCQMCYTGTCRKGIATQDPRLRkrLDYV 438  Methanothermobact...
O27702    277 AVKTVINEGHGDRVSLIAGGGLRTAADMAKCLALGADAVYTGTAALIALNCQQHRLCHTGKCPTGITTHDPDLLkhMDLE 356  Methanothermobact...

1OFE_A   1165 GVPGQVVNFFYFIAEEVRSLLAHLGYR 1191 Synechocystis sp. PCC 6803
CBS88067 1171 GTPEKVVNLFTFLAEEVREILARLGFR 1197
P39812   1141 GDPDHIVNYMLFIAEEVREYMAALGFK 1167 Bacillus subtilis subsp. subtilis str. 168
Q12680   1213 GQPEHVINFFYYLIQDLRQIMAKLGFR 1239 Saccharomyces cerevisiae S288C
Q8ILB1   1435 GKPEYIVNFFFMLAEEVREYLASMGFR 1461 Plasmodium falciparum 3D7
Q9ZNZ7   1265 GVPGDLVNYFLYVAEEVRGILAQLGYN 1291 thale cress
P09831   1131 GLPFKVTNYFEFIARETRELMAQLGVt 1157 Escherichia coli K-12
O34849    468 EKQHRVCNYVISLREGLFNLAAAAGIN 494  Bacillus subtilis subsp. subtilis str. 168
Q58746    452 VGARRVANLIKAWTHEIKELLGAAGIN 478  Methanocaldococcus jannaschii DSM 2661
O29309    453 ITAKRLVNLLRAWSHEIKEMLGGMGIN 479  Archaeoglobus fulgidus DSM 4304
O26208    568 LAARRVANYIKSMTEEAKMLAQLAGHD 594  Methanothermobacter thermautotrophicus str. Delta H
O26296    439 EAGKNVARYIEAMTEEVCMLTQQAGNT 465  Methanothermobacter thermautotrophicus str. Delta H
O27702    357 RAIEGLENFIRVSTAEIADFCQDHRKG 383  Methanothermobacter thermautotrophicus str. Delta H
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