1G60,6PBD,5HFJ,1NW6,6K0W,1BOO


Conserved Protein Domain Family
N6_N4_Mtase

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pfam01555: N6_N4_Mtase 
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DNA methylase
Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.
Statistics
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PSSM-Id: 396230
Aligned: 49 rows
Threshold Bit Score: 75.1289
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1G60_B  24 VQLAVIDPPYNLSKA----------------------DWDSFDSHNEFLAFTYRWIDKVLDK---------LDKDGSLYI 72  Moraxella bovis
O64360  22 LNHITWAKPSGVWRRqnkeslra------ffpateriIFAEHYGASGYAKGQSGYASKCAEL---------RKDVFSPLI 86  Escherichia virus N15
O58725  30 VR-ILEERIYGSNKSf--------------------aIIQAKEDIEKYFRWIGGSLKLVRLIgegvdsirdLEYSKLFTV 88  Pyrococcus horikoshii
O68568  27 ADLVYLDPPFFTNRRhssisrd---------rinafsFDDAWGDLGEYADFMEQRLREAHRV---------LKHSGSIFV 88  Xanthomonas campestris
O51937  94 VQLVYIDPPYGTGQQflvggdetdrvatvsqpkngqlGYDDTLDGPQFVEFLRERLILLREL---------MADSGLIFV 164 Thermus sp. YS45
P14827  93 AKLIYLDPPYATGMGfssr--------------snehAYDDCLTEAAYLEFMRRRLILMREI---------LDDDGTIYV 149 Enterobacter cloacae
P71366 261 VKLIYIDPPYNTGNDg--------------------fKYNDKFNHSTWLTFMKNRLEIAKTL---------LADDGVIFV 311 Haemophilus influenza...
O25922  30 LNGKTWSPP-----------------------------------SGTFWRYSIGTLKD-------------MEQNNRIVF 61  Helicobacter pylori
O25040  21 IQTIYIDPPYNTKSS----------------------NFEYEDDHADYEKWIKEHLILAKAV---------LKQSGCLFI 69  Helicobacter pylori
P70986  50 IHIVEETETFNRKLVs--------------------yQANKNQSIHNWIRYKEGFSSELVQNlie---efgLSKGDTILD 106 Geobacillus stearothe...
1G60_B  73 FNTPFNc------aFICQYLVSKG--MIFQNWITWDKRd---------GMGSAKr-----RFSTGQETILF--------- 121 Moraxella bovis
O64360  87 G-------------AFASARQQLGisAADINAATGKKMcshwfsssqwQLPSLD------DFNKLHELFMQraqvlgvac 147 Escherichia virus N15
O58725  89 SVYGRRvdwkewrrFGSMIKEV----FKEKDSAKFFKPa---------NTYAMPselilkGFPKVKDVVLL--------- 146 Pyrococcus horikoshii
O68568  89 HCDTSAnf-----lLRTLLNNIFGa-SQFRSEIIWSYk----------RWSNSAr-----NLLPAHQTILF--------- 138 Xanthomonas campestris
O51937 165 HIDEKYgf-----eVKLILDEVFGr-RNFVNHIARIASn---------PKNFSRk-----AFGSQKDMILV--------- 215 Thermus sp. YS45
P14827 150 HIGHQMlg-----eLKCLLDEIFGr-ERFINLITRRKCs---------SKNSTKn-----NFANLNDYILC--------- 200 Enterobacter cloacae
P71366 312 QCDDIEqa-----yLKILMDDIFDrdNFLNIVTVKTKIg--------gVSGSSEg----kSLKDSTEFINV--------- 365 Haemophilus influenza...
O25922  62 NGKNPMak----ryLSEVAEGRKSstFWDGSEVGY-------------------------NLNGDAEIKQL--------- 103 Helicobacter pylori
O25040  70 SMDDNKma-----eVKIIANEIFGtrNFLGTFITK-------------QATRSNa----kHINITHEYVLS--------- 118 Helicobacter pylori
P70986 107 PFLGSGtts---ltAKMLGINSIGidILPISHIAFEPKs---------FIFEYNl----eELDRAYKEIYE--------- 161 Geobacillus stearothe...
1G60_B 122 -------FSKSKNHtfn----------------------------------------------------ydEVRVPYEST 142 Moraxella bovis
O64360 148 pppfdigYSEHEKQyadlk------------------------------------------------tqydAVKAQYDGL 179 Escherichia virus N15
O58725 147 -------FVDDKVLvgetv------------------------------------------------rvtdPFELKKLDV 171 Pyrococcus horikoshii
O68568 139 -------YSKSDAYkfnvlhgsy----------------------------------------settnvdqILQLRQRDA 171 Xanthomonas campestris
O51937 216 -------YSKTRDYvwnesaspyseeeiarlfpfvdengeryttnplhapgetkdgptgrpwrgilpppgrHWRYPPEKL 288 Thermus sp. YS45
P14827 201 -------YSKGKKYiwnrplkkpdaewlakeypktdskgqfk--lvpihapgvrhgatggewkgmlpppgkHWQYTPEKL 271 Enterobacter cloacae
P71366 366 -------FSKNRERlflnpvyqktevnefiknyedsgkswkytqvlidlgekilleekdgfkyyhypnaqmTSIVKFSQD 438 Haemophilus influenza...
O25922 104 -------FNGNKVF------------------------------------------------------------------ 110 Helicobacter pylori
O25040 119 -------YAKNKAFapgfkilrtllpiyaralkd------------------lmrtiknvfkqkgqaqaqlVLKEQIKEL 173 Helicobacter pylori
P70986 162 -------ISPTKIEqkfnhlsitegafpeetendllff---------thwdnnsqysyqtktliklilvsiLEEISYTRK 225 Geobacillus stearothe...
1G60_B 143 DRIKHASekgilkngkrwfpnpngrl------------------------------------------------------ 168 Moraxella bovis
O64360 180 KAQYESLrrpfsvtadvpytd----------------------------------------------------------- 200 Escherichia virus N15
O58725 172 ERPVVRP------------------------------------------------------------------------- 178 Pyrococcus horikoshii
O68568 172 DGVSKYAtdklgntiygtekngvpl------------------------------------------------------- 196 Xanthomonas campestris
O51937 289 DELDAQGlivwskngvprkkvyardrl----------------------------------------------------- 315 Thermus sp. YS45
P14827 272 DILDASGdihwsktgnprrkvyltddk----------------------------------------------------- 298 Enterobacter cloacae
P71366 439 QNLSKEIiyteyshkvyrttnaqssirskiiedlysikngivsieyipqkgknagnlievfynasnkdmfmflsdmlike 518 Haemophilus influenza...
O25922     --------------------------------------------------------------------------------     Helicobacter pylori
O25040 174 SQKEHFNflknynlvdekgeiyfakdlstpsnprsvaieeinlfleplksrgw--------ssdeklkelyyqnrlifkn 245 Helicobacter pylori
P70986 226 DGQYLRWdyrsqkvietnkkrleqgke----------------------------------------------------- 252 Geobacillus stearothe...
1G60_B 169 -------cgevwhfssqrhkekvngkTv--------kLTHITPKPRDLIERIIRASSNP-----NDLVLDCFMGS----- 223 Moraxella bovis
O64360 201 --------------------------vwefppvqyypgkHPCEKPAAMMEHIIRSSSRP-----GDVVADFFMGS----- 244 Escherichia virus N15
O58725 179 ----------------------------------------TISIPPRLARVMVNLSEIR-----RGNVLDPFCGT----- 208 Pyrococcus horikoshii
O68568 197 ---------------------ndvwaipflnpkakertgYPTQKPILLLERIIEISTDP-----GDFIVDPFCGS----- 245 Xanthomonas campestris
O51937 316 --------------------kkgkklqdvwqfkdppypryPTEKNLDMLKLIVQTGSNE-----GDLVLDPFAGS----- 365 Thermus sp. YS45
P14827 299 -------sigytdyweefrdahhqsiLv--------tGY-PTEKNFNMMKLIVGASSNP-----GDLVIDPFCGS----- 352 Enterobacter cloacae
P71366 519 knkyfylqkvntlwddiqynnlnkegGyi-------dFK-NGKKPEALLRRIIDMTTKE-----GDIVLDYHLGS----- 580 Haemophilus influenza...
O25922 111 ----------------------------------------NNPKPEALLQRILEISTKE-----NDLVLDFFAGS----- 140 Helicobacter pylori
O25040 246 nrpyekyylkesqdnclsvldfysrqGtkdleklglkGLFKTPKPVALIKYLLLCSTPK-----DSIILDFFAGS----- 315 Helicobacter pylori
P70986 253 -------piktildkgelptvkesllNtlltikedikEIQQKCLPNESVHELIKDSALNalpkiNDNTFDAVITSppycn 325 Geobacillus stearothe...
1G60_B 224 --GTTAIVAKKLGRN---------------------FIGcd-mNAEYVN--QANF 252 Moraxella bovis
O64360 245 --GSTIKEALKLGRK---------------------AIGve-iEEERYL--QTVE 273 Escherichia virus N15
O58725 209 --GTIVMELTLQGLN---------------------AYGtd-iEEGRVR--DAKK 237 Pyrococcus horikoshii
O68568 246 --GTTLVAAAILGRR---------------------AFGid-tSREAVA--LANR 274 Xanthomonas campestris
O51937 366 --GTTLIASPLLKRR---------------------SIGid-aSWEAVK--AFTR 394 Thermus sp. YS45
P14827 353 --GSTLHAASLLQRK---------------------WIGid-eSLFAAK--TVMK 381 Enterobacter cloacae
P71366 581 --GTTAAVAHKMNRQ---------------------YIGie-qMDYIET--LAVE 609 Haemophilus influenzae Rd KW20
O25922 141 --GTTCAVAHKMKRK---------------------YIGie-mGEHFES--VILP 169 Helicobacter pylori
O25040 316 --GTTAQAVIEVNRDyclnwsfylcqkeekiknnpqAVSil-kNKGYQNtiSNIM 367 Helicobacter pylori
P70986 326 ryDYTRTYALELA-----------------------YLGvdekKIRELR--QAQL 355 Geobacillus stearothermophilus
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