Conserved Protein Domain Family
Amidase_3

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pfam01520: Amidase_3 
N-acetylmuramoyl-L-alanine amidase
This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.
Statistics
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PSSM-Id: 426303
Aligned: 62 rows
Threshold Bit Score: 100.013
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P57638          7 ILIDAGH-----GGY--DPGAIG-IRGLK-EKNINIEI-ALKLEKL-LNHDKm--FCTILTRHN-DSYL--SLKKRKQL- 69  Buchnera aphid...
Q03S01         51 ILV-MGH-----GAG--DSGARG--NGTTeATFLRQHL-LPQLRKYaIKVKH---SQVTFYNPKqD-----IVKDTLTYh 111 Lactobacillus ...
Q2FYD8        181 IMLVAGH-----GYN--DPGAVG--NGTN-ERDFIRKYiTPNIAKY-LRHAG---HEVALYGGS-SQSQ--DMYQDTAYg 243 Staphylococcus...
WP_009245051    3 igLRGGH-----SPN--CKGAIG---LID-EQAEVRKI-YNELVPM-LQAVG---HTVIDCNSN-ASNVsgELSDGTNK- 64  [Ruminococcus]...
Q183X8          3 IGINCGH-----TKTgaGSGAIG---KIN-ESIETRNV-GYKVIDK-LKKLGnnvVDCTIDKAS-TQSE--CLSKITAQ- 67  Clostridioides...
Q6LSI5          4 IALIIGH-----SAK--RGGAANkTHGIN-EFQFNEPL-AHCVAEK-LMLYG---FEPIIVYRD-S-----SYSKLPKK- 63  Photobacterium...
Q187L1          3 VVIIPGHtligkGT-----GAVG----YInESKETRIL-NDLIVKW-LKIGG---ATVYTGRVDeSSN---HLADQCAI- 64  Clostridioides...
WP_119962621   62 VCLDPGH-----GGS--DIGATG-INNIH-EKDGNLKL-SLKVAKL-LKKNG---VKVVMTRDD-DSTV--SSEERATI- 123 Clostridium sp...
jgi:Dole_2691  55 IALDPGH-----GGT--DTGTEG-SGGLL-EKEVTLAL-ARRVAAC-LEPR----YGVVLTRSG-DYRL--DGVDRAAL- 115
WP_012062720    3 IIIDSGH-----GGK--DPGAVA--FGMT-EKYLNLIF-AELLATQ-LEN-----LNIDVDRSLiNdi-yyTPKELTDL- 63  Alkaliphilus m...
P57638         70 -------------LKK---NQVNFLISIHAD-SSRKQNv-SGASIWIvsktrinreinnylknkstllfskkienifkqn 131 Buchnera aphid...
Q03S01        112 -------------kGSyklNRHATVVMFHLD---AAGG--HGGHVII--------------------------------- 140 Lactobacillus ...
Q2FYD8        244 vnvgnnkdyglywVKS---HGYDIVLEIHLD-AAGESA--SGGHVII--------------------------------- 284 Staphylococcus...
WP_009245051   65 -------------ANG---AGCDIYVTLHMN-AAGAASa-GGTEVWL--------------------------------- 93  [Ruminococcus]...
Q183X8         68 -------------ANR---QDLDWFISIHFN-A--GGG--KGCEVYT--------------------------------- 93  Clostridioides...
Q6LSI5         64 -------------VNQ---TGADIAVSFHCN-AFNDKS--NGSETLY--------------------------------- 91  Photobacterium...
Q187L1         65 -------------ANK---QETDLAVQIHFN-SNATTStpVGTETIY--------------------------------- 94  Clostridioides...
WP_119962621  124 -------------AND---CDADLYLALHRN-YAANPEa-CGVEAWI--------------------------------- 152 Clostridium sp...
jgi:Dole_2691 116 -------------ANS---RQADLFVSLHAGgGFSSTS--GGITVFYrglppdsllttad-------------------s 158
WP_012062720   64 -------------IKD---SGASICISCHNN-AFNGTV--RGFEVIH--------------------------------- 91  Alkaliphilus m...
P57638        132 kndfflkktildLQSNNFQKIELDLSKEILKQLEKNTKLNKKYPNYAS-----------LGILssi--ntPSILIETGFI 198 Buchnera aphid...
Q03S01        141 -------------HKRRPTARDKRLAQVIKKYVGLNRA--YHGYSYRTdlk-------ncnVLrkr--giDYSLIETGFI 196 Lactobacillus ...
Q2FYD8        285 ----------------SSQFNADTIDKSIQDVIKNNLGQ-IRGVTPRNdl-------lnVNVSaei--niNYRLSELGFI 338 Staphylococcus...
WP_009245051   94 --------------YDASNQTMNTIASNICNNFAGKGFT-NRGVKYSSg----------YHDLnas--nmPGMIVETLFC 146 [Ruminococcus]...
Q183X8         94 -------------YKGKQYQDAIDVCKKISD-----LGFTNRGVKDGSg----------LYVVkkt--kaKSMLIEVCFV 143 Clostridioides...
Q6LSI5         92 ---------------YKHSAKGILLASAIQKEVVHCLGLKDRGLKPCVasykgkagdrgGLLLqkt--smPCVIVEPFFI 154 Photobacterium...
Q187L1         95 -----------------KTNNGKTYAERVNTRLATVFK--DRGAKSDVr---------gLYWLnht--iaPAILIEVCFV 144 Clostridioides...
WP_119962621  153 --------------YSSGSEKNHAIAETILSNLEKVGISDNRGVRTGTqfds----dndYIVIkqt--nmTSLIIEMGFI 212 Clostridium sp...
jgi:Dole_2691 159 pessadtyslwdRVDEKQFYAARSLASLLRESFDPLAVSGDAVVRQAP-----------LAPLtgm--hmPAVLVEVGAI 225
WP_012062720   92 -----------------SIHTKDTLAKSIFEEVKKTNFIVRRVFSRRStvapg-sdqdyYYIIrlthphvETIIVEFGFM 153 Alkaliphilus m...
P57638        199 TNILEGKKLKTTNYQNKIANSIYLGLKN 226 Buchnera aphidicola str. APS (Acyrthosiphon pisum)
Q03S01        197 TNRTDMAHIRKNIGK--IAKADIEAITY 222 Lactobacillus brevis ATCC 367
Q2FYD8        339 TNKNDMDWIKKNYDL--YSKLIAGAIHg 364 Staphylococcus aureus subsp. aureus NCTC 8325
WP_009245051  147 TGTDDVARYRSLGTK-GIAEPIAKAIDs 173 [Ruminococcus] gnavus
Q183X8        144 DTEDANKYLSLGADK--LATAIVEAITK 169 Clostridioides difficile 630
Q6LSI5        155 DSDSSLELAQERFDD--LAKAYALGIKN 180 Photobacterium profundum
Q187L1        145 DSKADTDYYVNNKDK--VAKLIAEGILN 170 Clostridioides difficile 630
WP_119962621  213 SNEKDVELYDDNMDD--YAAAIANGIIe 238 Clostridium sp. AF15-41
jgi:Dole_2691 226 THPAVEDRFRDPDYLSALADAVCAAVDR 253
WP_012062720  154 DNAEDFKMLTDSVWQQRLTAAVATGISQ 181 Alkaliphilus metalliredigens
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