2YPT


Conserved Protein Domain Family
Peptidase_M48
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pfam01435: Peptidase_M48 
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Peptidase family M48
Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologs such as Human FACE-1 protease. These are metallopeptidases, with the characteriztic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit.
Links
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Statistics
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PSSM-Id: 426263
Aligned: 22 rows
Threshold Bit Score: 86.7159
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YPT_B        228 PLPEGKLKEEIEVMA--KSIDFPLT---Kvy--vvEGSKRsSHS------NAYFYGF-FKNKRIVLFDTLLEEYsvlnkd 293 human
P44840         72 NQTERWLIDTVSRQA--QKAGIPMP---D------VAIYHsPDV------NAFATGAtKSNSLVAVSTGLLNNM------ 128 Haemophilus in...
O25144        203 PLNNRDLESQIEGMM--DKVGFKSE---Gif--vmDASKRdGRL------NAYFGGL-GKNKRVVLFDTLISKV------ 262 Helicobacter p...
P40769        207 PLKNKELESKILELA--DEANIPAD---Hvy--evNMSEKtNAL------NAYVTGI-GANKRIVLWDTTLNKL------ 266 Bacillus subti...
jgi:Mfer_1108  73 PQEAPELHSIVEELA--RNAGIPKP---K------VGIAEiSIP------NAFAFGRsKRDGRVCVTRGILNLL------ 129
Q10071        262 PLENGSLRTQIEELA--ASINFPLK---Kly--viDASRRsTHS------NAFFYGLpWNKG-IVLFDTLVKNH------ 321 Schizosaccharo...
Q8RX88        213 PLPDGDLREKIEKLA--SSLKFPLK---Klf--vvDGSTRsSHS------NAYMYGF-FKNKRIVLYDTLIQQCk----- 273 thale cress
O30004        102 AQRDERLQMVVNSVA--RRLNVKPP---Ka-----VVVRSpP--------NAFAYGNfLTGKFVAVSESLMRML------ 157 Archaeoglobus ...
Q9RXW5        191 AARQAQLQREFKDVAqwAGGGYPYRlllRdgtpqaNGDKDsPAPsgsigtNAFA----LPGGTVVMTEQLVKLAh----- 261 Deinococcus ra...
Q9A748         78 LIRDTEIEEILHRDSdpIFAAAGLD---Pkn--vrILIVGdKSL------NAFA----TQGLQMGLNTGLILQTe----- 137 Caulobacter vi...

2YPT_B        294 iqedsgmeprneeegnseeikakvknkkqgcKNEEVLAVLGHALGHWKLGHTVKNIIIsQMNSFLCFFLF-AVLIGRKEL 372 human
P44840        129 -------------------------------TEAEAEAVLAHEISHISNGDMVTMALLqGVLNTFVIFLSrVIATAVASS 177 Haemophilus in...
O25144        263 -------------------------------GTEGLLAILGHELGHFKNKDLLKSLGImGGLLALVFALIaHLPPLVFEG 311 Helicobacter p...
P40769        267 -------------------------------DDSEILFIMGHEMGHYVMKHVYIGLAGyLLVSLAGFYVI-DKLYKRTVR 314 Bacillus subti...
jgi:Mfer_1108 130 -------------------------------DKEELKAVLGHEISHIRHNDMIVMTFI-SVVPLICYWIF-QSMYWGSLM 176
Q10071        322 -------------------------------TEPELIAILGHELGHWYMSHNLINTIIdYGMSLFHLFLF-AAFIRNNSL 369 Schizosaccharo...
Q8RX88        274 -------------------------------NEDEIVAVIAHELGHWKLNHTTYSFIAvQILAFLQFGGY-TLVRNSTDL 321 thale cress
O30004        158 -------------------------------SQEELEAVIGHEIGHHKHRDNAVMLLF-GLLPSVIFYLG-YALLHSSMR 204 Archaeoglobus ...
Q9RXW5        262 -------------------------------SDRELMGVLAHETGHVTHRHSLSSIYQgLGLTLLTTAVTgDLIGAS--- 307 Deinococcus ra...
Q9A748        138 -------------------------------NPNQLRGVIAHETGHLAGGHPIRSDEMmRAGLKPMILTMgLGVLAALAG 186 Caulobacter vi...

2YPT_B        373 FAAFGfydsqptligllIIFQFIFSPYNEVLsfCLTVLSRRFEFQADAFAKKLGKAKD--LY-SALIKLN---------- 439 human
P44840        178 RNNNGeetrssgiyflvSMVLEMLFGVLASI--IAMWFSRYREFRADAGSASLVGKEKmiMAlQRLQQLHepq------- 248 Haemophilus in...
O25144        312 FNVSQtpa------sliAILLLFLPVFSFYAmpLIGFFSRKNEYNADKFGASLSSKE---VLaKALVSIV---------- 372 Helicobacter p...
P40769        315 LTRSMfhlegrhdlaalPLLLLLFSVLSFAVtpFSNAVSRYQENKADQYGIELTENRE--AAvKTFQDLA---------- 382 Bacillus subti...
jgi:Mfer_1108 177 DRDRGssl-------aiIGILAFIAYMIGQL--LVLFVSRIREYYADLGSVEIGGKPH--KLaSALYKLVygsavvsken 245
Q10071        370 YTSFNfitekp-vivglLLFSDALGPLSSILtfASNKVSRLCEYQADAFAKQLGYAKD--LG-DGLIRIH---------- 435 Schizosaccharo...
Q8RX88        322 FRSFGfdtqp--vliglIIFQHTVIPLQHLVsfGLNLVSRAFEFQADAFAVKLGYAKD--LRp-ALVKLQ---------- 386 thale cress
O30004        205 DDRRGaql-------aaIGIAAVIVSFIVQI--LVLAFSRLREYYADFEGVRATNK-D--AMqRSLAKIHlfyhrypdyl 272 Archaeoglobus ...
Q9RXW5        308 -----------------------TFAAAVPTwlLKNGYSRQSETQSDEVAGRFLMERY--GTtKPLRDVLarle------ 356 Deinococcus ra...
Q9A748        187 APDAG---------------AVLIGNAQYAGalGALGYSREQESRADQAGAGFLEATG--QSgRGLVEFFd--------- 240 Caulobacter vi...

2YPT_B        440 --------------------------------KDNLGFPVSDWLF---------------SMWHYSHPPLLERLQALKTM 472 human
P44840        249 -----------------------------nleGSLNAFMINGKR----------------SELFMSHPPLEKRIEALRNL 283 Haemophilus in...
O25144        373 --------------------------------SENKAFPYSHPFY---------------VFLHFTHPPLLERLKALDYE 405 Helicobacter p...
P40769        383 --------------------------------VTGLSQVDPPVLV---------------KIFRGSHPSIMERIQHAEKE 415 Bacillus subti...
jgi:Mfer_1108 246 keevnqvsgfkafflndinqagheikdlkqvdMDMNGTISREELErlrytpvkigltekiLEIFSTHPNTLKRIKRLSEL 325
Q10071        436 --------------------------------DDNLSPLEFDSLY---------------TSYYHSHPILVDRLNAIDYT 468 Schizosaccharo...
Q8RX88        387 --------------------------------EENLSAMNTDPLY---------------SAYHYSHPPLVERLRAIDGE 419 thale cress
O30004        273 a--------------------piqdskfrtlfIYAFTNAVAEPITradiealknmkvspiQEFLSTHPPLPKRLRFIESI 332 Archaeoglobus ...
Q9RXW5        357 -----------------------------tedENADENSVKRDDP---------------GAFLQTHPGTAERIRHLREI 392 Deinococcus ra...
Q9A748        241 --------------------------------NFRYQEVFDQARR---------------FAYFRSHPLSSERIEVLRSR 273 Caulobacter vi...

2YPT_B        473 K 473 human
P44840            -     Haemophilus influenzae Rd KW20
O25144        406 I 406 Helicobacter pylori
P40769        416 E 416 Bacillus subtilis subsp. subtilis str. 168
jgi:Mfer_1108 326 T 326
Q10071        469 T 469 Schizosaccharomyces pombe 972h-
Q8RX88        420 D 420 thale cress
O30004        333 R 333 Archaeoglobus fulgidus DSM 4304
Q9RXW5        393 E 393 Deinococcus radiodurans
Q9A748        274 V 274 Caulobacter vibrioides
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