3DI2


Conserved Protein Domain Family
IL7

?
pfam01415: IL7 
Interleukin 7
IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-7 and IL-7Ralpha bind the gamma-c receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells.
Statistics
?
PSSM-Id: 460203
Aligned: 12 rows
Threshold Bit Score: 103.891
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3DI2_A         3 DCDIEG-KDG--KQYESVLMVSIDQLLd--SMKEIgSNCLNNEFNFFKRHICDAnKEGMFLFRAARKLRQFLK---M--- 71 
XP_012883907  26 DCHIKD-IDG--KAFENVIIISLDKLV---KIIGNdSDCLNNESNFFKKHSCDDtKKAAFLNRAAGKLKQFHN---M--- 93 
XP_008253910  26 NCDIEKiKHG--KEYENVLMISINE-Ld--KMIEIgSNCLNNESNFFKKHSCDDnKEADFLERAARKLDQFHD---M--- 94 
XP_002819245  26 DCDIEG-KDG--KQYESVLMVSIDQLLd--SMKEIgSNCLNNEFNFFKRHICDAnKEGMFLFRAARKLRQFLK---M--- 94 
XP_008069475  26 DCEIEG-KDG--KQYEKILMVSIDILLn--SMNEIgSNCLNNEPNFFRRHLCDDnKEGMFLYRAARKLKQFSKi------ 94 
XP_016047514  26 DCDIGG-KDG--EEYESVIMVSINYLVcwdNMLETdSSCLNNESNFFKKHSCDDnKEAVFLNRAAHRLNKFKM------- 95 
Q28540        26 DCDFSG-KDG--GAYQNVLMVSIDD-Ld--NMINFdSNCLNNEPNFFKKHSCDDnKEASFLNRAARKLKQFLK---M--- 93  sheep
NP_001041603  26 DCDIEG-KDG--REYQHVLMISIND-Ld--IMIKNrTNCSNNEPNILKKHACDDnKEGMFLYRAAHKLKQFVK---V--- 93 
XP_007486982  45 DCEIEEkNKT--IIMKDYIHLLHEGIEileKAINF-ANCSSKEYSSLKNHTCDD-KEVTFIVHVTCKLKQLVKannIpen 120
XP_005338095  26 DCDIKG-KEG--KEFEHVLMISFNE-Ld--KMIEVdSNCVNNESNFFKRHSCGDsKEAAFLNRAARKLNQFLK---M--- 93  thirteen-lined ...
XP_023607687  26 DCEIEG-KSG--EEYQHVIMVSLND-Ld--RIRENdSNCLNNEPNFFKKHSCDDdKEATFLKTAARKLKQFLK---M--- 93  little brown bat
XP_014726196  26 TCAMGNrT-EirVKYENILSHDINELVn-mSAEDRdRCCKNKKYGNIKVFFCNDtEEIESLQSMACNMLRFYN------- 96  Common starling
3DI2_A        72 -NSTGDFDLHLLKVSEGTTI-LLNCTGQvkgrkpaalgaaqptkslEENKSLKEQKKlNDLCFLKRLLQEIKTCWNKILM 149
XP_012883907  94 -NISEDFGDHLSKVSEGTLA-LVNCTSR------------------KEEKSKKDKKK-SDPCFLKRLLEEIKTCWNKILM 152
XP_008253910  95 -SINEDFQNHLERVSKGTLT-LVNCTGK------------------EEKKPLKDQKK-NGRCFLKKLLQKIKTCWNKILR 153
XP_002819245  95 -NSTGDFDLHLLKVSEGTTI-LLNCTGQvkgrkpsalgeaqptkslEENKSLKEQKKlNDLCFLKRLLQEIKTCWNKILM 172
XP_008069475  95 -NSTEDFNIHLLRVSEGTLT-LLNCTSKvkgkktpsvgeaqptknlEENKFLKEQKKqNDSCFLKRLLQKIKTCWNKILS 172
XP_016047514  96 -NISEDFNIHLLKVSRGTLTlLLKCKSKvkerklissgeaqptknlENNKWAEEQQK----CLLKILLQKIKTCWNKILK 170
Q28540        94 -NISDDFKLHLSTVSQGTLT-LLNCTSKgkgrkppslgeaqptknlEENKSLKEQRKqNDLCFLKILLQKIKTCWNKILR 171 sheep
NP_001041603  94 -NNSEDFNLHLSRVSQGTLQ-LLNCTPK------------------EDNKSLKEQRKqKSLCSLGILLQKIKTCWNKILR 153
XP_007486982 121 lSHSLEVYSHHALGILKGCKcDEVNGTEkkaggpcffvendpnknpGEKSAKEQKKErKCKCLIKKMVSDVKNCWRKFLM 200
XP_005338095  94 -NMSEDFELHLSRISEGTLK-LLSCPSK-------------------EEKNVKEQKK-NDPCFLKTLLQKIKTCWNKILR 151 thirteen-lined ...
XP_023607687  94 -NIHEEFKLHLSIVSQGTLK-LLNCTRKdkekkqpslgevqptknlEEKKSSKGQKKqDEMCFLMILLEKIKTCWNKILS 171 little brown bat
XP_014726196  97 -----------------------------------------------KRRISKAFREkAAFVSCGTL--QVLQCKCRTKR 127 Common starling
3DI2_A       150 GTKEH 154
XP_012883907 153 GSTEP 157
XP_008253910 154 GIKEN 158
XP_002819245 173 GTKEH 177
XP_008069475 173 GTKGH 177
XP_016047514 171 EHAGT 175
Q28540       172 GITEH 176 sheep
NP_001041603 154 GSKEH 158
XP_007486982 201 TSNGD 205
XP_005338095 152 GNKEH 156 thirteen-lined ground squirrel
XP_023607687 172 GTKEH 176 little brown bat
XP_014726196 128 EKVCl 132 Common starling
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap