3DI2


Conserved Protein Domain Family
IL7

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pfam01415: IL7 
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Interleukin 7/9 family
IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.
Statistics
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PSSM-Id: 426253
Aligned: 12 rows
Threshold Bit Score: 98.391
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DI2_A         3 DCDIEG-KDG--KQYESVLMVSIDQLLd--SMKEIgSNCLNNEFNFFKRHICDAnKEGMFLFRAARKLRQFLK---M--- 71  human
XP_012883907  26 DCHIKD-IDG--KAFENVIIISLDKLV---KIIGNdSDCLNNESNFFKKHSCDDtKKAAFLNRAAGKLKQFHN---M--- 93  Ord's kangaroo rat
3_pfamImport   1 SCAMGNrTTEirVKYENILSHDINELVn-mSAEDRdKCCRNKKNGNIKVFFCNDtEEIESLQSMACNMLRFYK------- 72 
XP_008253910  26 NCDIEKiKHG--KEYENVLMISINE-Ld--KMIEIgSNCLNNESNFFKKHSCDDnKEADFLERAARKLDQFHD---M--- 94  rabbit
XP_002819245  26 DCDIEG-KDG--KQYESVLMVSIDQLLd--SMKEIgSNCLNNEFNFFKRHICDAnKEGMFLFRAARKLRQFLK---M--- 94  Sumatran orangutan
XP_008069475  26 DCEIEG-KDG--KQYEKILMVSIDILLn--SMNEIgSNCLNNEPNFFRRHLCDDnKEGMFLYRAARKLKQFSKi------ 94  Philippine tarsier
XP_016047514  26 DCDIGG-KDG--EEYESVIMVSINYLVcwdNMLETdSSCLNNESNFFKKHSCDDnKEAVFLNRAAHRLNKFKM------- 95  western Europea...
Q28540        26 DCDFSG-KDG--GAYQNVLMVSIDD-Ld--NMINFdSNCLNNEPNFFKKHSCDDnKEASFLNRAARKLKQFLK---M--- 93  sheep
1_pfamImport   1 DCEIEG-KSG--EEYQHVIMVSLND-Ld--RIRENdSNCLNNEPNFFKKHSCDDdKEATFLKTAARKLKQFLK---M--- 68 
NP_001041603  26 DCDIEG-KDG--REYQHVLMISIND-Ld--IMIKNrTNCSNNEPNILKKHACDDnKEGMFLYRAAHKLKQFVK---V--- 93  dog
2_pfamImport   1 DCDIKG-KEG--KEFEHVLMISFNE-Ld--KMIEVdSNCVNNESNFFKRHSCGDsKEAAFLNRAARKLNQFLK---M--- 68 
XP_007486982  45 DCEIEEkNKT--IIMKDYIHLLHEGIEileKAINF-ANCSSKEYSSLKNHTCDD-KEVTFIVHVTCKLKQLVKannIpen 120 gray short-tail...
3DI2_A        72 -NSTGDFDLHLLKVSEGTTI-LLNCTGQvkgrkpaalgaaqptkslEENKSLKEQKKlNDLCFLKRLLQEIKTCWNKILM 149 human
XP_012883907  94 -NISEDFGDHLSKVSEGTLA-LVNCTSR------------------KEEKSKKDKKK-SDPCFLKRLLEEIKTCWNKILM 152 Ord's kangaroo rat
3_pfamImport  73 -----------------------------------------------KQRISKALREkAAFVSCGTL--QVLQCKCRTKK 103
XP_008253910  95 -SINEDFQNHLERVSKGTLT-LVNCTGK------------------EEKKPLKDQKK-NGRCFLKKLLQKIKTCWNKILR 153 rabbit
XP_002819245  95 -NSTGDFDLHLLKVSEGTTI-LLNCTGQvkgrkpsalgeaqptkslEENKSLKEQKKlNDLCFLKRLLQEIKTCWNKILM 172 Sumatran orangutan
XP_008069475  95 -NSTEDFNIHLLRVSEGTLT-LLNCTSKvkgkktpsvgeaqptknlEENKFLKEQKKqNDSCFLKRLLQKIKTCWNKILS 172 Philippine tarsier
XP_016047514  96 -NISEDFNIHLLKVSRGTLTlLLKCKSKvkerklissgeaqptknlENNKWAEEQQK----CLLKILLQKIKTCWNKILK 170 western Europea...
Q28540        94 -NISDDFKLHLSTVSQGTLT-LLNCTSKgkgrkppslgeaqptknlEENKSLKEQRKqNDLCFLKILLQKIKTCWNKILR 171 sheep
1_pfamImport  69 -NIHEEFKLHLSIVSQGTLK-LLNCTRK------------------EEKKSSKGQKKqDEMCFLMILLEKIKTCWNKILS 128
NP_001041603  94 -NNSEDFNLHLSRVSQGTLQ-LLNCTPK------------------EDNKSLKEQRKqKSLCSLGILLQKIKTCWNKILR 153 dog
2_pfamImport  69 -NMSEDFELHLSRISEGTLK-LLSCPSK-------------------EEKNVKEQKK-NDPCFLKTLLQKIKTCWNKILR 126
XP_007486982 121 lSHSLEVYSHHALGILKGCKcDEVNGTEkkaggpcffvendpnknpGEKSAKEQKKErKCKCLIKKMVSDVKNCWRKFLM 200 gray short-tail...
3DI2_A       150 GTKEH 154 human
XP_012883907 153 GSTEP 157 Ord's kangaroo rat
3_pfamImport 104 EKVCP 108
XP_008253910 154 GIKEN 158 rabbit
XP_002819245 173 GTKEH 177 Sumatran orangutan
XP_008069475 173 GTKGH 177 Philippine tarsier
XP_016047514 171 EHAGT 175 western European hedgehog
Q28540       172 GITEH 176 sheep
1_pfamImport 129 GTKEH 133
NP_001041603 154 GSKEH 158 dog
2_pfamImport 127 GNKEH 131
XP_007486982 201 TSNGD 205 gray short-tailed opossum
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