Conserved Protein Domain Family
KRAB

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pfam01352: KRAB 
KRAB box
The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Statistics
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PSSM-Id: 426216
Aligned: 458 rows
Threshold Bit Score: 43.1899
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001005425   7 PVLFEDVS-VVFTQKEWQLLDAAQRHLYREVMLETYRHLRAVG 48  house mouse
7_pfamImport   1 GKTFRYLTeLTYHQKIHADEKPYEYNACGQPFSERKQFILHYP 43 
CAH56173       5 FVTLKDVG-MDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLD 46  human
XP_017195977  47 VTFSDVAV-DFSPEEWGWLSSAQRDLYREVTVQNYENLVSLGL 88  rabbit
XP_016278214  15 VTLKDVAV-DFTQEEWRVLNPSQKELYREVMLENVLNMLSVGL 56  gray short-tailed opossum
Q8NHY6       231 LVTIKNLA-VDFRQQ----LHPAQKNFCKNGIWENNSDLGSAG 268 human
XP_004776997 235 LVAIANVA-VDFSQQ----LDPARKSICKNMRWESHGDLGSVG 272 domestic ferret
XP_023413192  13 SVLFEDLA-EYFSQEECVSLHPVQRSLSKGATQECFKDVAWLG 54  African savanna elephant
XP_003478186  13 PVLFDDLA-VYFSQEECVTLHPAQGSHSREATQESFEDVALMG 54  domestic guinea pig
PNI81103      64 TVAYEDLS-VDYTQKKWKGLTLSQRALQWNMMPENHHSMASLD 105 chimpanzee
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