Conserved Protein Domain Family
Parvo_NS1

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pfam01057: Parvo_NS1 (484622 is an unknown moldel)
Parvovirus non-structural protein NS1
This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.
Statistics
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PSSM-Id: 484622
Aligned: 24 rows
Threshold Bit Score: 171.338
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q66NY3        41 NnkdiykadktardeffsdfvhnNNYHSLIggig-------lgaKNLIEEHVlgnslygmGKRKNTEKDWATIK-----R 108 Dendrolimus pun...
P07296       317 L----------------------SRKQKIM--------------AEVIQRAT--------DGLLLTYNDLVVHLsdlmlM 352 Bovine parvovir...
Q65023       281 TdqtdsatsktgtsliwkscatkVTSKKEVanpvqqpskklysaQNTLDALF--------NVGCFTPEDMIIKQsdkylE 352 Aleutian mink d...
P05842       288 NhkevfqadkqardefftsfvhiGNVHSLIggig-------lgtKNLVEEHVlgkplygmGKRKSTEKDWAKIK-----R 355 Bombyx mori den...
Q993M6         2 Q----------------------TRKEVSI--------------KTTLKELV--------HKRVTSPEDWMMMQpdsyiE 37  Autonomous rat ...
Q00683       225 K--------------------------SKF--------------LGTIEWLS--------DLGIVTEDAWIRRDirsymQ 256 Human herpesvir...
Q9DW64        55 E-----------------------SPVDKL--------------PKMVATLI--------EYGIVNENTWCLEEfesylE 89  Rat cytomegalov...
Q89621         1 M----------------------SRESERY--------------WTLVHALI--------DRGVVSREQWQMVDpaqyqF 36  Fowl aviadenovi...
1_pfamImport   1 M----------------------SGSRDRY--------------WSLVESLI--------NRGIVTRQQWYFNDrseygY 36 
2_pfamImport   1 M------------------------ASDRY--------------WDLVNSLI--------NRGIVTREQWQSADlaeyrR 34 
Q66NY3       109 INRARAARRERENDLNQPDIRNFGHVAGENINPDEEVNl-------ADFPDFLQDFVAEAGPSGTQPLETAQESPPVMSQ 181 Dendrolimus pun...
P07296       353 LEGMPGGSKTAEQLLTMIHIKLCAKYNAYEFMLMKTPAtqnmnpgaPHYDCQGNLVFKLLNLQGYNPWQVGHWLVMMLSK 432 Bovine parvovir...
Q65023       353 LSLEPNGPQKINTLLHMNQVKTSTMMTAFDCIIKFNEE------------EDDKPLLATIKDMGLNEQYLKKVLCTILTK 420 Aleutian mink d...
P05842       356 INRARAARR--ENQENQPDIREFGHVAGQNINADQEVNl-------ADFPDFLQDFDAEAGPSGTQPVETAQQSPPTMSE 426 Bombyx mori den...
Q993M6        38 MMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETsk-----lANFSMASTRTCRIFAEHGWNYIKVCHAICCVLNR 112 Autonomous rat ...
Q00683       257 LLTLTHGDVLIHRALSIAKKRIRATRKAIDFIAHIDTD----------FQIYENPVYQLFCLQSFDPILAGTILYQWLSH 326 Human herpesvir...
Q9DW64        90 VQSDPVKRARARKAISVARRYLGTRESPLRYVIKGDGTt-------VARDICDNPTYRLIRTHNLNPRVVAGVLWAFLRS 162 Rat cytomegalov...
Q89621        37 YHRSKQRGFKVRHILRDVIRHMCWSRTLLDYMSSASTP--------SPDDVLRNPLYQLLLCNGYNPAVVGTALIRWAGH 108 Fowl aviadenovi...
1_pfamImport  37 YTKRYRGAMKLSNLFRDVRRHMFWTKCLADYMLTPETD---------FLQIEENPFYSVFSKNGYDPALVGSMLLAWAAR 107
2_pfamImport  35 YSKGYVRGFSVRKVLRDVIKHMCWTKVLGDYLVCPVVC---------QDDIHLNPFYVILMKNGYNPRVVGTILHKWSML 105
Q66NY3       182 ENVPMDTEGATdvgggaqvdprs--ggqaaggmgggGAANDGRQDIFAgapqpnqnheliygksyhfTLTNGLPDFRH-- 257 Dendrolimus pun...
P07296       433 KTGKRNSTLFY-------------------------GPASTGKTNLAK-------------------AICHAVGLYGCv- 467 Bovine parvovir...
Q65023       421 QGGKRGCIWFY-------------------------GPGGTGKTLLAS-------------------LICKATVNYGMv- 455 Aleutian mink d...
P05842       427 DIQPMETVGATdtgggaqvdprtggqaaggsemgagGSANDGREDIFSgapqpnqhhtlvygksyhfTITKWFTEFRHl- 505 Bombyx mori den...
Q993M6       113 QGGKRNTVLFH-------------------------GPASTGKSIIAQ-------------------AIAQAVGNVGCy- 147 Autonomous rat ...
Q00683       327 RGGKKNTVSFI-------------------------GPPGCGKSMLTG-------------------AILENIPLHGIlh 362 Human herpesvir...
Q9DW64       163 RHTPKNCLWLY-------------------------GEADTGALDLAN-------------------AIMACVPLTGIl- 197 Rat cytomegalov...
Q89621       109 Q-SNRNTVWIR-------------------------GTPMSGAPYLAQ-------------------AIAYCSPLVGSv- 142 Fowl aviadenovi...
1_pfamImport 108 Q-SKRNTVWIR-------------------------GAPVTGAPYLAE-------------------AIAYCCPLMTCv- 141
2_pfamImport 106 T-SNKNTVWVW-------------------------GGAETGGPYLAE-------------------AIAYTSPVVGCv- 139
Q66NY3       258 -AITNNAYSAQLRFKHIHGiPWERLLMYVSEGELLRLMRDYTALKVE--------------EVVCEVYSLGVRLPFV-TS 321 Dendrolimus pun...
P07296       468 -NHNNKQFPFNDAPNKMIL-WWEECIMTTDYVEAAKCVLGGTHVRVDvkhkd-----srelPQIPVLLSSNHDVYTV-VG 539 Bovine parvovir...
Q65023       456 -TTSNPNFPWTDCGNRNII-WAEECGNLGNWVEDFKAITGGGDVKVDtknkq-----pqsiKGC-VIVTSNTNITKV-TV 526 Aleutian mink d...
P05842       506 -ATTNSGYYAQQRFKHIHGiPWERLLMYVSEGELLRMFRDYTSLKVE--------------EVVCEVYSLGVRLPFV-TS 569 Bombyx mori den...
Q993M6       148 -NAANVNFPFNDCTNKNLI-WVEEAGNFGQQVNQFKAICSGQTIRIDqkgkg-----skqiEPTPVIMTTNENITVV-RI 219 Autonomous rat ...
Q00683       363 gSLNTKNL---RAYGQVLVlWWKDISINFDNFNIIKSLLGGQKIIFPinend-----hvqiGPCPIIATSCVDIRSM-VH 433 Human herpesvir...
Q9DW64       198 -VGTPTQEDLAACVDKLLI-WWRDPPENVLVSDTYRSLLAGMLLKVrakev------tkslRKTPVLVTTGRELVRT-ED 268 Rat cytomegalov...
Q89621       143 -DWRNKSNPFEGCPDSLVF-WWDGGYVYDCCVGLVKQVFRGEHVILPpeglrgp-npcselFRTPVLMYSQADICMTrLR 219 Fowl aviadenovi...
1_pfamImport 142 -DWRNKQNPFEKGFESLLF-WWDGGHVPHRCVALCRQVFRGENVMFPredgq-----mselVRTPVLLYSEHDACRTlVK 214
2_pfamImport 140 -DWRNRANPFARNYNCLVY-WLDGGLFPESAIGLCEQVLRGEGTMVEveegatgerrwreiNRTPVLISTSHDVTLTyVK 217
Q66NY3       322 ATTSSVANANAqypigcfhfdnaYEIQYDATQVNDVINKAlgaeWKNSTRPDTPVST-QWSETfpnisassTSRDISNPV 400 Dendrolimus pun...
P07296       540 GNATFGVHAAP------------LKERITQMNFMKQLPNT----FGEITPGMISNWL-SHCAHihqehlslEGFAIKWDV 602 Bovine parvovir...
Q65023       527 GCVETNAHAEP------------LKQRMIKIRCMKTINPK-----TKITPGMLKRWLnTWDRQ---------PIQLSHEM 580 Aleutian mink d...
P05842       570 ATTSSVANANAqypidvfhfdeaYETNYGINNVADIINKAlgteWKNATRPTAPVTT-AWSEQfpnisassTSRDINNPV 648 Bombyx mori den...
Q993M6       220 GCEERPEHTQP------------IRDRMLNIHLTRTLPGD----FGLVDKHEWPLIC-AWLVK--------NGYQSTMAC 274 Autonomous rat ...
Q00683       434 SN----LHKIN------------LSQRVYNFTFDKVIPRN----FPVIQKDDINQFL-FWARN--------RSINCFIDY 484 Human herpesvir...
Q9DW64       269 GS----PNAVH------------LKSKMWKVCLAGTVSQD----MLGLRSRDVREFL-QWLEM--------IEMGETASM 319 Rat cytomegalov...
Q89621       220 SGELSAEHAVG------------LRDCMYLIRLTEDFDCA-----GGISCADVKQFV-AWSREh------pGEVRETHEL 275 Fowl aviadenovi...
1_pfamImport 215 WGVFSDEFSDG------------LRNSMYCLDLSAPMEGA-----QCVTCADARAFF-TWAYP----------RRMDFDC 266
2_pfamImport 218 YGQTCKDHTNS------------LRSAMYVLRLTERVEPG-----FVITCNDARKFV-TWASN---------NPHINAED 270
Q66NY3       401 I 401 Dendrolimus punctatus densovirus
P07296       603 Q 603 Bovine parvovirus 1
Q65023       581 P 581 Aleutian mink disease virus
P05842       649 I 649 Bombyx mori densovirus
Q993M6       275 Y 275 Autonomous rat parvovirus RV-Y
Q00683       485 T 485 Human herpesvirus 6 (strain Uganda-1102)
Q9DW64       320 N 320 Rat cytomegalovirus Maastricht
Q89621       276 K 276 Fowl aviadenovirus 1
1_pfamImport 267 F 267
2_pfamImport 271 M 271
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