Conserved Protein Domain Family
Parvo_NS1

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pfam01057: Parvo_NS1 
Parvovirus non-structural protein NS1
This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.
Statistics
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Aligned: 24 rows
Threshold Bit Score: 171.338
Threshold Setting Gi: 81936477
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q66NY3    41 NnkdiykadktardeffsdfvhnNNYHSLIggig-------lgaKNLIEEHVlgnslygmGKRKNTEKDWATIK-----R 108 Dendrolimus punctat...
Q2LD59   317 L----------------------SRKQKIM--------------AEVIQRAT--------DGLLLTYNDLVVHLsdlmlM 352 Bovine parvovirus-1
Q65023   281 TdqtdsatsktgtsliwkscatkVTSKKEVanpvqqpskklysaQNTLDALF--------NVGCFTPEDMIIKQsdkylE 352 Aleutian mink disea...
P05842   288 NhkevfqadkqardefftsfvhiGNVHSLIggig-------lgtKNLVEEHVlgkplygmGKRKSTEKDWAKIK-----R 355 Bombyx mori densovirus
Q993M6     2 Q----------------------TRKEVSI--------------KTTLKELV--------HKRVTSPEDWMMMQpdsyiE 37  Autonomous rat parv...
Q00683   225 K--------------------------SKF--------------LGTIEWLS--------DLGIVTEDAWIRRDirsymQ 256 Human herpesvirus 6...
Q9DW64    55 E-----------------------SPVDKL--------------PKMVATLI--------EYGIVNENTWCLEEfesylE 89  Rat cytomegalovirus...
Q89621     1 M----------------------SRESERY--------------WTLVHALI--------DRGVVSREQWQMVDpaqyqF 36  Fowl aviadenovirus 1
Q9YYR9     1 M----------------------SGSRDRY--------------WSLVESLI--------NRGIVTRQQWYFNDrseygY 36  Fowl aviadenovirus 8
AMQ81251   1 M------------------------ASDRY--------------WDLVNSLI--------NRGIVTREQWQSADlaeyrR 34  Fowl aviadenovirus C
Q66NY3   109 INRARAARRERENDLNQPDIRNFGHVAGENINPDEEVNl-------aDFPDFLQDFVAEAGPSGTQPLETAQESPPVMSQ 181 Dendrolimus punctat...
Q2LD59   353 LEGMPGGSKTAEQLLTMIHIKLCAKYNAYEFMLMKTPAtqnmnpgapHYDCQGNLVFKLLNLQGYNPWQVGHWLVMMLSK 432 Bovine parvovirus-1
Q65023   353 LSLEPNGPQKINTLLHMNQVKTSTMMTAFDCIIKFNEE------------EDDKPLLATIKDMGLNEQYLKKVLCTILTK 420 Aleutian mink disea...
P05842   356 INRARAARR--ENQENQPDIREFGHVAGQNINADQEVNl-------aDFPDFLQDFDAEAGPSGTQPVETAQQSPPTMSE 426 Bombyx mori densovirus
Q993M6    38 MMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETsk-----laNFSMASTRTCRIFAEHGWNYIKVCHAICCVLNR 112 Autonomous rat parv...
Q00683   257 LLTLTHGDVLIHRALSIAKKRIRATRKAIDFIAHIDTD----------FQIYENPVYQLFCLQSFDPILAGTILYQWLSH 326 Human herpesvirus 6...
Q9DW64    90 VQSDPVKRARARKAISVARRYLGTRESPLRYVIKGDGTt-------vARDICDNPTYRLIRTHNLNPRVVAGVLWAFLRS 162 Rat cytomegalovirus...
Q89621    37 YHRSKQRGFKVRHILRDVIRHMCWSRTLLDYMSSASTPs--------PDDVLRNPLYQLLLCNGYNPAVVGTALIRWAGH 108 Fowl aviadenovirus 1
Q9YYR9    37 YTKRYRGAMKLSNLFRDVRRHMFWTKCLADYMLTPETD---------FLQIEENPFYSVFSKNGYDPALVGSMLLAWAAR 107 Fowl aviadenovirus 8
AMQ81251  35 YSKGYVRGFSVRKVLRDVIKHMCWTKVLGDYLVCPVVC---------QDDIHLNPFYVILMKNGYNPRVVGTILHKWSML 105 Fowl aviadenovirus C
Q66NY3   182 ENVPMDTEGATdvgggaqvdprs--ggqaaggmgggGAANDGRQDIFAgapqpnqnheliygksyhfTLTNGLPDFRH-- 257 Dendrolimus punctat...
Q2LD59   433 KTGKRNSTLFY-------------------------GPASTGKTNLAK-------------------AICHAVGLYGCv- 467 Bovine parvovirus-1
Q65023   421 QGGKRGCIWFY-------------------------GPGGTGKTLLAS-------------------LICKATVNYGMv- 455 Aleutian mink disea...
P05842   427 DIQPMETVGATdtgggaqvdprtggqaaggsemgagGSANDGREDIFSgapqpnqhhtlvygksyhfTITKWFTEFRHl- 505 Bombyx mori densovirus
Q993M6   113 QGGKRNTVLFH-------------------------GPASTGKSIIAQ-------------------AIAQAVGNVGCy- 147 Autonomous rat parv...
Q00683   327 RGGKKNTVSFI-------------------------GPPGCGKSMLTG-------------------AILENIPLHGIlh 362 Human herpesvirus 6...
Q9DW64   163 RHTPKNCLWLY-------------------------GEADTGALDLAN-------------------AIMACVPLTGIl- 197 Rat cytomegalovirus...
Q89621   109 Q-SNRNTVWIR-------------------------GTPMSGAPYLAQ-------------------AIAYCSPLVGSv- 142 Fowl aviadenovirus 1
Q9YYR9   108 Q-SKRNTVWIR-------------------------GAPVTGAPYLAE-------------------AIAYCCPLMTCv- 141 Fowl aviadenovirus 8
AMQ81251 106 T-SNKNTVWVW-------------------------GGAETGGPYLAE-------------------AIAYTSPVVGCv- 139 Fowl aviadenovirus C
Q66NY3   258 -AITNNAYSAQLRFKHIHGiPWERLLMYVSEGELLRLMRDYTALKVE--------------EVVCEVYSLGVRLPFV-TS 321 Dendrolimus punctat...
Q2LD59   468 -NHNNKQFPFNDAPNKMIL-WWEECIMTTDYVEAAKCVLGGTHVRVDvkhkd-----srelPQIPVLLSSNHDVYTV-VG 539 Bovine parvovirus-1
Q65023   456 -TTSNPNFPWTDCGNRNII-WAEECGNLGNWVEDFKAITGGGDVKVDtknkq-----pqsiKGC-VIVTSNTNITKV-TV 526 Aleutian mink disea...
P05842   506 -ATTNSGYYAQQRFKHIHGiPWERLLMYVSEGELLRMFRDYTSLKVE--------------EVVCEVYSLGVRLPFV-TS 569 Bombyx mori densovirus
Q993M6   148 -NAANVNFPFNDCTNKNLI-WVEEAGNFGQQVNQFKAICSGQTIRIDqkgkg-----skqiEPTPVIMTTNENITVV-RI 219 Autonomous rat parv...
Q00683   363 gSLNTKNL---RAYGQVLVlWWKDISINFDNFNIIKSLLGGQKIIFPinend-----hvqiGPCPIIATSCVDIRSM-VH 433 Human herpesvirus 6...
Q9DW64   198 -VGTPTQEDLAACVDKLLI-WWRDPPENVLVSDTYRSLLAGMLLKVrakev------tkslRKTPVLVTTGRELVRT-ED 268 Rat cytomegalovirus...
Q89621   143 -DWRNKSNPFEGCPDSLVF-WWDGGYVYDCCVGLVKQVFRGEHVILPpeglrgp-npcselFRTPVLMYSQADICMTrLR 219 Fowl aviadenovirus 1
Q9YYR9   142 -DWRNKQNPFEKGFESLLF-WWDGGHVPHRCVALCRQVFRGENVMFPredgq-----mselVRTPVLLYSEHDACRTlVK 214 Fowl aviadenovirus 8
AMQ81251 140 -DWRNRANPFARNYNCLVY-WLDGGLFPESAIGLCEQVLRGEGTMVEveegatgerrwreiNRTPVLISTSHDVTLTyVK 217 Fowl aviadenovirus C
Q66NY3   322 aTTSSVANANAqypigcfhfdnaYEIQYDATQVNDVINKAlgaeWKNSTRPDTPVST-QWSETfpnisassTSRDISNPV 400 Dendrolimus punctat...
Q2LD59   540 gNATFGVHAAP------------LKERITQMNFMKQLPNT----FGEITPGMISNWL-SHCAHihqehlslEGFAIKWDV 602 Bovine parvovirus-1
Q65023   527 gCVETNAHAEP------------LKQRMIKIRCMKTINPK-----TKITPGMLKRWLnTWDRQ---------PIQLSHEM 580 Aleutian mink disea...
P05842   570 aTTSSVANANAqypidvfhfdeaYETNYGINNVADIINKAlgteWKNATRPTAPVTT-AWSEQfpnisassTSRDINNPV 648 Bombyx mori densovirus
Q993M6   220 gCEERPEHTQP------------IRDRMLNIHLTRTLPGD----FGLVDKHEWPLIC-AWLVK--------NGYQSTMAC 274 Autonomous rat parv...
Q00683   434 sN----LHKIN------------LSQRVYNFTFDKVIPRN----FPVIQKDDINQFL-FWARN--------RSINCFIDY 484 Human herpesvirus 6...
Q9DW64   269 gS----PNAVH------------LKSKMWKVCLAGTVSQD----MLGLRSRDVREFL-QWLEM--------IEMGETASM 319 Rat cytomegalovirus...
Q89621   220 sGELSAEHAVG------------LRDCMYLIRLTEDFDCA-----GGISCADVKQFV-AWSREh------pGEVRETHEL 275 Fowl aviadenovirus 1
Q9YYR9   215 wGVFSDEFSDG------------LRNSMYCLDLSAPMEGA-----QCVTCADARAFF-TWAYP----------RRMDFDC 266 Fowl aviadenovirus 8
AMQ81251 218 yGQTCKDHTNS------------LRSAMYVLRLTERVEPG-----FVITCNDARKFV-TWASN---------NPHINAED 270 Fowl aviadenovirus C
Q66NY3   401 I 401 Dendrolimus punctatus densovirus
Q2LD59   603 Q 603 Bovine parvovirus-1
Q65023   581 P 581 Aleutian mink disease virus
P05842   649 I 649 Bombyx mori densovirus
Q993M6   275 Y 275 Autonomous rat parvovirus RV-Y
Q00683   485 T 485 Human herpesvirus 6 (strain Uganda-1102)
Q9DW64   320 N 320 Rat cytomegalovirus Maastricht
Q89621   276 K 276 Fowl aviadenovirus 1
Q9YYR9   267 F 267 Fowl aviadenovirus 8
AMQ81251 271 M 271 Fowl aviadenovirus C
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