Conserved Protein Domain Family
Parvo_NS1

?
pfam01057: Parvo_NS1 
Parvovirus non-structural protein NS1
This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.
Statistics
?
PSSM-Id: 307276
View PSSM: pfam01057
Aligned: 24 rows
Threshold Bit Score: 171.726
Threshold Setting Gi: 81936477
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81936477   41 NnkdiykadktardeffsdfvhnNNYHSLIggig-------lgaKNLIEEHVlgnslygmGKRKNTEKDWATIK-----R 108
gi 123833648 317 L----------------------SRKQKIM--------------AEVIQRAT--------DGLLLTYNDLVVHLsdlmlM 352
gi 81935471  281 TdqtdsatsktgtsliwkscatkVTSKKEVanpvqqpskklysaQNTLDALF--------NVGCFTPEDMIIKQsdkylE 352
gi 128572    288 NhkevfqadkqardefftsfvhiGNVHSLIggig-------lgtKNLVEEHVlgkplygmGKRKSTEKDWAKIK-----R 355
gi 81966177    2 Q----------------------TRKEVSI--------------KTTLKELV--------HKRVTSPEDWMMMQpdsyiE 37
gi 231453    225 K--------------------------SKF--------------LGTIEWLS--------DLGIVTEDAWIRRDirsymQ 256
gi 81968832   55 E-----------------------SPVDKL--------------PKMVATLI--------EYGIVNENTWCLEEfesylE 89
gi 82011592    1 M----------------------SRESERY--------------WTLVHALI--------DRGVVSREQWQMVDpaqyqF 36
gi 81982824    1 M----------------------SGSRDRY--------------WSLVESLI--------NRGIVTRQQWYFNDrseygY 36
gi 407829732 305 P----------------------NKKEKLM--------------LNLLDKCK--------ELNLLVYEDLVANCpelllM 340
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81936477  109 INRARAARRERENDLNQPDIRNFGHVAGENINPDEEVNl-------aDFPDFLQDFVAEAGPSGTQPLETAQESPPVMSQ 181
gi 123833648 353 LEGMPGGSKTAEQLLTMIHIKLCAKYNAYEFMLMKTPAtqnmnpgapHYDCQGNLVFKLLNLQGYNPWQVGHWLVMMLSK 432
gi 81935471  353 LSLEPNGPQKINTLLHMNQVKTSTMMTAFDCIIKFNEE------------EDDKPLLATIKDMGLNEQYLKKVLCTILTK 420
gi 128572    356 INRARAARR--ENQENQPDIREFGHVAGQNINADQEVNl-------aDFPDFLQDFDAEAGPSGTQPVETAQQSPPTMSE 426
gi 81966177   38 MMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETsk-----laNFSMASTRTCRIFAEHGWNYIKVCHAICCVLNR 112
gi 231453    257 LLTLTHGDVLIHRALSIAKKRIRATRKAIDFIAHIDTD----------FQIYENPVYQLFCLQSFDPILAGTILYQWLSH 326
gi 81968832   90 VQSDPVKRARARKAISVARRYLGTRESPLRYVIKGDGTt-------vARDICDNPTYRLIRTHNLNPRVVAGVLWAFLRS 162
gi 82011592   37 YHRSKQRGFKVRHILRDVIRHMCWSRTLLDYMSSASTPs--------PDDVLRNPLYQLLLCNGYNPAVVGTALIRWAGH 108
gi 81982824   37 YTKRYRGAMKLSNLFRDVRRHMFWTKCLADYMLTPETD---------FLQIEENPFYSVFSKNGYDPALVGSMLLAWAAR 107
gi 407829732 341 LEGQPGGARLIEQVLGMHHINVCSNFTALTYLFHLHPVt--------SLD-SDNKALQLLLIQGYNPLAVGHALCCVLNK 411
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81936477  182 ENVPMDTEGATdvgggaqvdprs--ggqaaggmgggGAANDGRQDIFAgapqpnqnheliygksyhfTLTNGLPDFRH-- 257
gi 123833648 433 KTGKRNSTLFY-------------------------GPASTGKTNLAK-------------------AICHAVGLYGCv- 467
gi 81935471  421 QGGKRGCIWFY-------------------------GPGGTGKTLLAS-------------------LICKATVNYGMv- 455
gi 128572    427 DIQPMETVGATdtgggaqvdprtggqaaggsemgagGSANDGREDIFSgapqpnqhhtlvygksyhfTITKWFTEFRHl- 505
gi 81966177  113 QGGKRNTVLFH-------------------------GPASTGKSIIAQ-------------------AIAQAVGNVGCy- 147
gi 231453    327 RGGKKNTVSFI-------------------------GPPGCGKSMLTG-------------------AILENIPLHGIlh 362
gi 81968832  163 RHTPKNCLWLY-------------------------GEADTGALDLAN-------------------AIMACVPLTGIl- 197
gi 82011592  109 Q-SNRNTVWIR-------------------------GTPMSGAPYLAQ-------------------AIAYCSPLVGSv- 142
gi 81982824  108 Q-SKRNTVWIR-------------------------GAPVTGAPYLAE-------------------AIAYCCPLMTCv- 141
gi 407829732 412 QFGKQNTVCFY-------------------------GPASTGKTNMAK-------------------AIVQGIRLYGCv- 446
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81936477  258 -AITNNAYSAQLRFKHIHGiPWERLLMYVSEGELLRLMRDYTALKVE-------------EVVCEVYSLGVRLPFV-TSa 322
gi 123833648 468 -NHNNKQFPFNDAPNKMIL-WWEECIMTTDYVEAAKCVLGGTHVRVDvkhkd----srelPQIPVLLSSNHDVYTV-VGg 540
gi 81935471  456 -TTSNPNFPWTDCGNRNII-WAEECGNLGNWVEDFKAITGGGDVKVDtknkq----pqsiKGC-VIVTSNTNITKV-TVg 527
gi 128572    506 -ATTNSGYYAQQRFKHIHGiPWERLLMYVSEGELLRMFRDYTSLKVE-------------EVVCEVYSLGVRLPFV-TSa 570
gi 81966177  148 -NAANVNFPFNDCTNKNLI-WVEEAGNFGQQVNQFKAICSGQTIRIDqkgkg----skqiEPTPVIMTTNENITVV-RIg 220
gi 231453    363 gSLNTKNL---RAYGQVLVlWWKDISINFDNFNIIKSLLGGQKIIFPinend----hvqiGPCPIIATSCVDIRSM-VHs 434
gi 81968832  198 -VGTPTQEDLAACVDKLLI-WWRDPPENVLVSDTYRSLLAGMLLKVrakev-----tkslRKTPVLVTTGRELVRT-EDg 269
gi 82011592  143 -DWRNKSNPFEGCPDSLVF-WWDGGYVYDCCVGLVKQVFRGEHVILPpeglrgpnpcselFRTPVLMYSQADICMTrLRs 220
gi 81982824  142 -DWRNKQNPFEKGFESLLF-WWDGGHVPHRCVALCRQVFRGENVMFPredgq----mselVRTPVLLYSEHDACRTlVKw 215
gi 407829732 447 -NHLNKGFVFNDCRQRLVV-WWEECLMHQDWVEPAKCILGGTECRIDvkhrd----svllTQTPVIISTNHDIYAV-VGg 519
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81936477  323 TTSSVANANAqypigcfhfdnaYEIQYDATQVNDVINKAlgaeWKNSTRPDTPVST-QWSETfpnisassTSRDISNPVI 401
gi 123833648 541 NATFGVHAAP------------LKERITQMNFMKQLPNT----FGEITPGMISNWL-SHCAHihqehlslEGFAIKWDVQ 603
gi 81935471  528 CVETNAHAEP------------LKQRMIKIRCMKTINPK-----TKITPGMLKRWLnTWDRQ---------PIQLSHEMP 581
gi 128572    571 TTSSVANANAqypidvfhfdeaYETNYGINNVADIINKAlgteWKNATRPTAPVTT-AWSEQfpnisassTSRDINNPVI 649
gi 81966177  221 CEERPEHTQP------------IRDRMLNIHLTRTLPGD----FGLVDKHEWPLIC-AWLVK--------NGYQSTMACY 275
gi 231453    435 N----LHKIN------------LSQRVYNFTFDKVIPRN----FPVIQKDDINQFL-FWARN--------RSINCFIDYT 485
gi 81968832  270 S----PNAVH------------LKSKMWKVCLAGTVSQD----MLGLRSRDVREFL-QWLEM--------IEMGETASMN 320
gi 82011592  221 GELSAEHAVG------------LRDCMYLIRLTEDFDCA-----GGISCADVKQFV-AWSREh------pGEVRETHELK 276
gi 81982824  216 GVFSDEFSDG------------LRNSMYCLDLSAPMEGA-----QCVTCADARAFF-TWAYP----------RRMDFDCF 267
gi 407829732 520 NSVSHVHAAP------------LKERVIQLNFMKQLPQT----FGEITATEIAALL-QWCFN---------EYDCTltgf 573
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap