1E90,6G6W


Conserved Protein Domain Family
PI3K_rbd

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pfam00794: PI3K_rbd 
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PI3-kinase family, ras-binding domain
Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding pfam00788 domains (unpublished observation).
Statistics
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PSSM-Id: 395642
Aligned: 12 rows
Threshold Bit Score: 95.4385
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1E90_A         62 TSKPLPEYLLkkiTNNCVFIVIHRS------------TTSQTIKVSADDTPGTILQSFFTKmakKKSLMDIPESQne--- 126  pig
O00750        364 AVTPSPEHLG---DEVNLKVTVLCDr----------lQEALTFTCNCSSTVDLLIYQTLCY---THDDLRNVDVG----- 422  human
O00443        409 SPVTAQRNICg--ENASVKVSIDIEg----------fQLPVTFTCDVSSTVEIIIMQALCW---VHDDLNQVDVG----- 468  human
XP_002030170  433 sIKVIVHPALntlQSNVLAASMGKEqvk-------gyGMPVTFTCDIDSVVAQVVAQALAS----LEGQVKGTVT----- 496 
P54675        724 AARLTPYPPPk-tIPEFFVIRVHLFk-----------NQTKSLRCANNHTAFSLMTILSEK----LKNTTPFDPT----- 782  Dictyostelium...
P54673        688 LVRLSPLPIPi--VGNKILISIFLPi----------tQVTKTLDLELNETADQFTNRLFTK---NYSKHLPNVNSn---- 748  Dictyostelium...
P54674        808 MIYVSSEPLPl-tIPNKITIMVLLPgd---------gKIIKRVDCCPNSSVGDVKKEIFKKfamIDRVHTQGKTQd---- 873  Dictyostelium...
Q94125        241 VGESCPKDLEskvKAAKLSYQMFWRkrkaeingvcekMMKIQIEFNPNETPKSLLHTFLYEm-rKLDVYDTDDPAde--- 316  Caenorhabditi...
XP_009893617  173 sSPELPKHIYnklDKGQIIVVIWVIvsp------nndKQKYTLKINHDCVPEQVIAEAIRKk--TRSMLLSSEQLklcvl 244 
P91634        200 NSTKMPELIRerhPTRTFLIVVKNEn----------dQSTFTLSVNEQDTPFSLTESTLQKm--NRSQMKMNDRTs---- 263  fruit fly
6G6W_A        203 AQTWGPGTLRl--PNRALLVNVKFEg----------sEESFTFQVSTKDVPLALMACALRK---KATVFRQPLVEqp--- 264  human
P42338        180 HEPSIPENLEdklYGGKLIVAVHFEn----------cQDVFSFQVSPNMNPIKVNELAIQK---RLTIHGKEDEVsp--- 243  human
1E90_A        127 ---rDFvLRVCGRDEYLV-GETPIKNFQWVRQCLKNGEEIHLVLDTPPD 171  pig
O00750        423 ----DFvLKPCGLEEFLQ-NKHALGSHEYIQYCRKFDIDIRLQLMEQKV 466  human
O00443        469 ----SYvLKVCGQEEVLQ-NNHCLGSHEHIQNCRKWDTEIRLQLLTFSA 512  human
XP_002030170  497 ----DYaVKPIGLLEWLA-PTSRLSQLECVHNSFQLEKDVHLGLCLStt 540 
P54675        783 ----QYrFLITGINQYVD-PNVPLLSVEYIVEKIKRKGEIDLTMVELLS 826  Dictyostelium discoideum
P54673        749 ----DFiLKVVGSSDFIH-GPHDIRTFESIRNHIIQGTKPQLTLIQRPK 792  Dictyostelium discoideum
P54674        874 ----DFvLKVTGFREYIL-CIHELGNLTSRQRFYPTGSGGDFSLMDYDY 917  Dictyostelium discoideum
Q94125        317 ---gWF-LQLAGRTTFVTnPDVKLTSYDGVRSELESYRCPGFVVRRQSL 361  Caenorhabditis elegans
XP_009893617  245 eyqgKYiLKVCGCDEYLL-EKYPLSQYKYIRSCIMLGRMPNLMLMAKEs 292 
P91634        264 ----DYiLKVSGRDEYLL-GDYPLIQFLYIQEMLSDSAVPNVVLQSVYR 307  fruit fly
6G6W_A        265 ---eDYtLQVNGRHEYLY-GSYPLCQFQYICSCLHSGLTPHLTMVHSSS 309  human
P42338        244 ---yDYvLQVSGRVEYVF-GDHPLIQFQYIRNCVMNRALPHFILVECCK 288  human
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