Conserved Protein Domain Family

cl10870: NDFIP-like Superfamily 
NEDD4 family-interacting protein
The NEDD4 (neural precursor cell expressed, developmentally down-regulated protein 4)-family interacting proteins (NDFIPs) are adaptor proteins that recruit NEDD4 E3 ligases to specific substrate proteins, which leads to the ubiquitylation and subsequent degradation of these proteins. They also act as activators of the E3 ligase activity by releasing NEDD4 ligase from its auto-inhibitory conformation. NDFIP1/2 have been shown to be involved in neural development by regulating the expression of the Robo1 receptor.
Accession: cl10870
PSSM Id: 415965
Name: NDFIP-like
Created: 25-Nov-2008
Updated: 24-Nov-2020
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