Conserved Protein Domain Family
DUF2370

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pfam10176: DUF2370 
Protein of unknown function (DUF2370)
This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.
Statistics
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PSSM-Id: 401984
View PSSM: pfam10176
Aligned: 48 rows
Threshold Bit Score: 237.166
Threshold Setting Gi: 299749781
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKD02284     108 FLPrqrgqdehapgpgVGGGQSGVFANLSARPDgqhggegeegsewANE---NeLKDAPPSYQTALRDAVPPYWDTTVVL 184 Trichosporon as...
XP_003684999 115 FFHkpte-----vndqHGASYDGVFSNLTAKPT--------------PEvpeEvNEDFPPTYTDAANDMSPSYYGANADG 175 Tetrapisispora ...
XP_002495031  81 LFRrniqr---tshlqHGASFDGVFSNLSAKPD--------------TGsrdVvEDDNPPTYEEAAIDMAPSYYGVDDDG 143 Zygosaccharomyc...
XP_003678842  78 LFQrntqd---ashlqQGANYDGVFSNLSAKPD-------------GEEdqqAgDSDNPPTYDEAAVDMAPSYYGVDDSG 141 Torulaspora del...
XP_001386866  85 FIG---------------SGTDGVFRNLMAKPD--------------TEatrQeQETNPPSYEEAAADATPEYWESTVIS 135 Scheffersomyces...
EGW31637     118 FIG---------------QGTDGVFRNLAAKPD--------------TEaslQlKETNPPSYEEAAADSAPEYWESSVIS 168 Spathaspora pas...
XP_004197939 163 FIG---------------QGTDGVFRNLMAKPD--------------REstrIaQENHPPTYEEAAADAAPEYWESAIVS 213 Pichia farinosa...
Q6BLR2       156 FIG---------------QGTDGVFRNLMAKPD--------------REanrT-EETHPPSYEEAAADATPEYWESTVVS 205 Debaryomyces ha...
XP_001487480 172 FIG---------------HGTDGVFRNLMAKPD--------------TEsnrIgQEQHPPSYEEAAADAVPEYWESTIIS 222 Meyerozyma guil...
XP_006689804 158 FIG---------------QGTDGVFRNLMAKPD--------------TEyngAkNETNPPTYEEAAADSTPEYWETSVIA 208 Yamadazyma tenu...
EKD02284     185 PSSTSpfgplsssisgDEILIDGMPAGNLFGFVWNLAVSAAFWLPGFLLTYVLHTTHAAKHGSRAGLGVTLLRYAFHLRS 264 Trichosporon as...
XP_003684999 176 TNMFY-----------DEICIEGLPVGNVANLIWNIIVSTSFQFIGFLITYVLHTSHAAKQGSRFGLGLTFIGYGYSMVP 244 Tetrapisispora ...
XP_002495031 144 SGLYY-----------NEICIEGLPTGNIANFVWNMVVSTCFQFVGFLITYILHTSHAAKQGSRFGLGLTMLGYSYSMIP 212 Zygosaccharomyc...
XP_003678842 142 AGMYY-----------NEICIEGLPVGNIANLIWNLLVSSSFQFIGFLVTYILHTSHAAKQGSRLGLGITFLGYAYSMIP 210 Torulaspora del...
XP_001386866 136 PLYE------------DEVFVEGLPVGNIANFVWNGLVTVAFQFIGFVLCYLLHTSHAAKHGSRAGLGITFIFYGWGMVP 203 Scheffersomyces...
EGW31637     169 PMYE------------DEVFVEGLPVGNIANFVWNALVTIAFQFVGFVLCYLLHTSHAAKHGSRAGLGITLIMYGWSIVP 236 Spathaspora pas...
XP_004197939 214 PMFD------------DEVFIEGLPVGNIANFVWNILVTTAFQFVGFVLCYLLHTSHAAKQGSRAGLGATFMYSGYNLLP 281 Pichia farinosa...
Q6BLR2       206 PLYE------------DEVFVEGLPVGNVANLVWNILVSSAFQFVGFVLCYLLHTSHAAKQGSRAGLGVTFIYYGLGMIP 273 Debaryomyces ha...
XP_001487480 223 PIYE------------DEVFVEGLPVGNIANFVWNALVTVAFQFVGFVLCYLLHTSHAAKEGSRTGLGITFVFYGWNMVP 290 Meyerozyma guil...
XP_006689804 209 PIYE------------DEVFVEGLPVGNIANFVWNMLVTVAFQFVGFLLCYLLHTSHAAKHGSRAGLGVVFIFYGWNLVP 276 Yamadazyma tenu...
EKD02284     265 VAQE-LLKAGHFPGEMEVVDPATGKLAGDKQaedmlknfgstiefpqpwsppaEwGgGNETYIIHSLeeaehivhkynht 343 Trichosporon as...
XP_003684999 245 SDVTsKVGKGTIINRVKVSNPNDYD----------------------------------------DLrideqnenldtf- 283 Tetrapisispora ...
XP_002495031 213 NDVRsKVGKDNVLDRVEVPDPTDYD----------------------------------------DLhlytrptsqdef- 251 Zygosaccharomyc...
XP_003678842 211 NDVQsKVGRDKDVDRVQLSDPNEHD----------------------------------------DLhlysspatqdef- 249 Torulaspora del...
XP_001386866 204 SNFG---HADKVPSKYEPSDPNVFDVDKSSTv---------------------PvD-HLDTYN-SGIfqqhadd------ 251 Scheffersomyces...
EGW31637     237 TNFG---HPDKVPSRFIPQDPNSFDIDKSSRi-----------------------GgKIDNYTPTGVfvqnde------- 283 Spathaspora pas...
XP_004197939 282 SNFG---KADVTPIKYIPSDPNQIDVNKSMSm---------------------KkGsSIDSYK-SELasqktp------- 329 Pichia farinosa...
Q6BLR2       274 SNFG---SAEKVPDRYEPNNPNQIDIDQSASv---------------------NdG-KLDNYQ-SGIfqqhtd------- 320 Debaryomyces ha...
XP_001487480 291 ANFG---SLDAVPIRYQPTDPNLVDITHSLSi---------------------KgG-KVDGYK-SDIfqqnv-------- 336 Meyerozyma guil...
XP_006689804 277 SNFG---SADKLPDRYEPKNPNNYNIDKNTAi---------------------DdA-GVDNYA-SDLyshqa-------- 322 Yamadazyma tenu...
EKD02284     344 lldvvgqsapevgRANEWFSFMLMIIGWFLILASIGGWLRVKRFEYKLQAAQRE 397 Trichosporon asahii var. asahii CBS 8904
XP_003684999 284 -tstlshgvqeekKSLPLLAIVVGGLGLYISIKSLIDYVKVKRMEKKYLAQDdp 336 Tetrapisispora phaffii CBS 4417
XP_002495031 252 -qsslsrgntedqQKLPALAIFVGLFGAFISIKGIYDYVMVKRMESKYMTQEra 304 Zygosaccharomyces rouxii
XP_003678842 250 -tshlstgiteekQSVPAVAVFTGILGFCIAVKSLYDYVQIKRMERKYMs---- 298 Torulaspora delbrueckii
XP_001386866 252 ------psagsvaNSTPYISYGIIAFGLFIIIKSVVDYYRVKQMEKVILSPPNR 299 Scheffersomyces stipitis CBS 6054
EGW31637     284 --------vvqdsGNAPYVAYGLVAFGLFIIIKSLIDYYRVKKTERAILSPrve 329 Spathaspora passalidarum NRRL Y-27907
XP_004197939 330 --------nmtmeVKTPYFAYGVIALGIFVVVKAFIDFSNIKRMESTVLAPmns 375 Pichia farinosa CBS 7064
Q6BLR2       321 -------spdkklNQTPYFAYGIIAFGIFIIVKAFIDYYRVKQMERVILSPPSN 367 Debaryomyces hansenii
XP_001487480 337 --------dtephLKTPYFAYALIAFGLFMVLKSFVDYYRVKQIEHQIFAPHRQ 382 Meyerozyma guilliermondii ATCC 6260
XP_006689804 323 ---------detvSTTPYFAYGLIAFGLLVICKALVDYYRVKQMEQVILHPPgs 367 Yamadazyma tenuis ATCC 10573
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