Conserved Protein Domain Family
DUF4455

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pfam14643: DUF4455 
Domain of unknown function (DUF4455)
This domain family is found in bacteria and eukaryotes, and is approximately 480 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.
Statistics
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PSSM-Id: 464231
Aligned: 23 rows
Threshold Bit Score: 377.391
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:MICPUN_104071  108 ARQRRERHERVVAAWTGERARLADVARARVATAVRELRDAIATSDASLAKGTGVYDDDAALVELTSDDAIKVWDeFVATR 187 
EEN65433           131 AESRRQRHESTLEDMHQELGVISTDTEPKIANLGETLMGYLEENDQEIDQLLSRIADDSELIDYSLQQLRDLWV-MVASQ 209 
EKC33617           338 AASRQKRHESTVEDLHQELSLINSDLEPVITEYSETLLRKLDDDDKEINHLLARIEKDEDLLTYNLEELYKLWD-QVQHH 416 
EGD78892            39 GRDRHDRHISAWNKLHADLAAVREEVDERIMEHSQRARQKILESDEEARELLAQLQDDRALRTMSWQQVVMCRT-MITEH 117 
EFJ43278           119 MEGQMERHNEAWEAFVRAREEARADLEEAVAAAAASFQQRLAGDDAGIAEDMSAL-DDDRVMRLTGQELYQVWD-CVAQR 196 
XP_003057208       114 KGSREERHSLTTAAWDEERDSLCEEARERVARAVGAFRERMQRSDDAMASRTSVYDDDDALMRVEEDEVRSVWDeIANAS 193 
XP_001323276        25 QERLASKYSQIVKKLQDKANSQSSECRMQMANKMMLYRQAESEILTNQKAICDSLGTTQEHYDVLKEKLQKLSDeLLEKS 104 
A0DIZ4             100 KDNRREKHLKFCDEFEKWVNRLNKNLEEAYKDIKRDITDFFSESDQQITNYYQTL-TDEALLKREIEFVESIHS-TVNAH 177  Parameci...
EGR27437            30 RENRREKHLKTLNDFEKWIESLEKDVLLNYKEIKNDIDNYFIINDKQLDDYFEKL-NDDVLLKREKNIIQEIND-IVKQC 107 
4_pfamImport         1 AEKRKEKHEKTLEEMYHDLSMISNRVEPRITSIGENLQQQLKEDDQIIEAEFSPIIEDTSLVNFSHDQLEKVWR-QIESH 79  
jgi:MICPUN_104071  188 LRDRQLWIDNLEKDVASAATETREEMASALAHTVDALTAVAHVSRGDVERFAAEATMEINADALEDRRGVAELLARLRTR 267 
EEN65433           210 SSVRREKIHELDSELQKVEDSRMDQISEVLQSYAKTLEQIAHMMAPDVQRRMEKEAMEINQSVLANKRAYADLFARLMTA 289 
EKC33617           417 SAERQAWINELDQQLSKVEDDRMDMMRNIFKSYAKTLEKIAHLMPPDLNRFLDQESQLVNQTMLSNRRAYSDLFVRLMSA 496 
EGD78892           118 LQGCNSIIDTLYNTLMEIEAQRVEKLRGVLRDAHRLIVSIAHVLPSEADRMVYAEAEEINRTMLDNYVAYADVKAQLLAD 197 
EFJ43278           197 IPQRARWIEECSAALEAAEERRREAVESALVSLCAGLNDAAVVSEGEVERLVEKEAMALNVAILENRRAYADLITRLQVT 276 
XP_003057208       194 IPTRSSWIDALVAEIDVAEKEVKEKLRESMTYVIDALVAVAHKTRGEIERYAADETSALNKQSIEDRRGVAELVKRLRTR 273 
XP_001323276       105 RNLKTDCMELYDNTF--------KSLHPLVEECFNESQDIIPQMPVAYADKLPRCVSTLNVNYLRNKQELIKTFFTIELG 176 
A0DIZ4             178 REKRETKVNALDKRLEDLEKERFRSLELFCNRFQEGLIDVAFQLEPEITAHVDTFREEFRKVVAEKRAENQVYVQDVNRQ 257  Parameci...
EGR27437           108 EVKKKNKVNNLDEKLEELEKERENNFIFFCNKLEFSLIEIAFMLEPQVKELVNIKRDEFQKSVKENRILNEEYVKNTEEQ 187 
4_pfamImport        80 STTRRHYIKDTNEWFNQAEDERLDAIAGVFRKFSSKLIKVASLSTPDVHRLIEKESMMINQSVLANRRAYEKLHINLMES 159 
jgi:MICPUN_104071  268 EVELERSERGRYDAALVKWRTLRTERGVSLFAELIESERMSDNPEREAITRELAEDQVKARDSLLAHADAF-----K-AL 341 
EEN65433           290 DVEREKKQHLQWLDRVGDWRELNTKRTIEQFREFMQSAPVVQPPGADQVLEHLLTEQKAQAQKRMDLLNSI-----K-DM 363 
EKC33617           497 DIEREKSQYTIWKRRVEDWRQLNTKLAIEHFSNFMQEEKIINPPSLSLSLSLSLSLS----------LHKIfyvskS-DL 565 
EGD78892           198 RVNMEEHMDVQWEILSERWKHFKEQDLTQQCLDTILDLTAYDEQRCLR-LDQFNRDLHDLMQTRIELMKSA-----A-HL 270 
EFJ43278           277 EVEAERTRRAAWQDGLRRWRVLRTQHAIRTFVERIRSTEFSEPAERLAAFAALRERQSQALSALTAHWGRA-----G-SV 350 
XP_003057208       274 EVEMEKREFARWEEGLEKWRRVRTEHCIAEYEALIASDALQDPPTRRELMESLATHQAGAHASLVENVERL-----GrNH 348 
XP_001323276       177 VMRQNASLMDEFQHRTDEWKANRFNSLVADAK---NKFNPNNTIDLMPFYENFHQEQGRFTLCCKKLLQNI-----S-LV 247 
A0DIZ4             258 HQKTFKLYDETQIQKEQRWRDLKHQHYIEEFNVDIQKLEFVYPDERTKLYDNFRKTQKDIFRERKQLLEKL-----N-SI 331  Parameci...
EGR27437           188 QLKALENFIQKRDQKILRWKQLKHDEALNIFNVEIQTMEYVNPNQRKELYQELKDRQVEIFKGKNEFLDKV-----N-NI 261 
4_pfamImport       160 DIQRELDQHRTWCERLADWKKLNAEFAVQKFTEFMKSTAIINPPGVERVMETMLKEQKELSDARQQILEQI-----Q-QL 233 
jgi:MICPUN_104071  342 LPggfdgepgsfdgvgslSRAGVELnpvgVKRWAAGLLARCDAWDGACALGLKRLETLESTLRAEADEALATVVAAVEEY 421 
EEN65433           364 KP----------------PSSTKTS----VYEWYNALSTVNEQIDQLHVQYMGKLHGEYEKVCQECLTEIEKYRESLLTR 423 
EKC33617           566 KP----------------PASTKTA----VYQWDKTIQNLTKEIDSVNQLHLTKLHAEYEKVCQDCLEKIEFIKKSLIDD 625 
EGD78892           271 SP----------------AFAAASEydarLQAWQADMRNIHNTYAQMHHTLRSDLQRLLQEKQDECNAAVTSCLRSLVDE 334 
EFJ43278           351 SP----------------PHLSSKK----VANWKAEVAALEEAWAKERQQHLGEMRSSEDALCARVADLVAALRAEVEGY 410 
XP_003057208       349 LP----------------PGTQY------IERWEQGFEVRHEDHGKVVDHFLEKLRADETRISAEASQTFETLRADVQRY 406 
XP_001323276       248 AP----------------PAQFSMDd---LNKWWAEVEDILSLHAEFIKQFTAKLQAKVDEVNNENAEYLQKLEQELVTL 308 
A0DIZ4             332 DM----------------AALTKTI----VEKWIDETKAYNELASQTIDVCCNNLLEETKKTHAHCMQRYELIKSQLLYA 391  Parameci...
EGR27437           262 DM----------------NALSKSY----CEKQLEELQKYNNTAQLYFDQIFDKIMQESEENKQKCTQRVFQLQQRLNYI 321 
4_pfamImport       234 QP----------------PSSTKPS----VYKWNTALTKANEDLDKLHLKMVRSLHEEYEAVCQSCLSEIEKYKQNLLLS 293 
jgi:MICPUN_104071  422 AGpIMDQRArEKLVRKRCVRVYDKRNADASDYIERVRSMVEPQRVEWRRKCECLMRFARRVARCRDVHRREAEAIHESVF 501 
EEN65433           424 GI-CSQERS-LQVINEHFLPLVGERQRAFEDKLEAMDKALEELSEESANQLKSLFKFAQGGAHIWDVHEIGLAKQERALQ 501 
EKC33617           626 GV-CAPPRA-QQVVDQHMLPLVGERQRVFENNLETMEKDLENHMKEMTERLKMLFKFAQGAAHVWDVHEIGLAKQERALQ 703 
EGD78892           335 NV-CSPERA-RLLVDRECRHACVVVLRDSHKETEAFVQALDDVSATLHAEADALTEICRSLYEQWTECGQMVAQQEDAVV 412 
EFJ43278           411 QG-YPPDQL-DELVREQAGLATEERRQAALGLLAQTEAFLEQQAARWAAVSAALGGWLGKLCAMYDGHRAVTATDEAEVR 488 
XP_003057208       407 AA-YDEETQ-FAMLEERAMTPAVKRAEEAQAFIDRVETFMREQAADWKDKSEKLVDFMRRVSKYREKHFAKTEKIHEDNV 484 
XP_001323276       309 KE--ETESS-AAI--AEITPLLRASQKYNATVVEKLTKYWENRKVALRKSFESIKEFVTPLINDYAEYTTKLNTFKQNYE 383 
A0DIZ4             392 RA-KSEEEL-NQLLDEQFLPQVNGLNQSARDLMKQAINYYERIDQQQTDIITNFGQFYMKIAQKNDEYKTEMQLLIHNYE 469  Parameci...
EGR27437           322 EN-LPENEI-EVLLNEQINPIIIQLYENSRQQIKKSMQFQEEQDFKQNELVQNILKVFLKIGEKNDDSKKNMQKLNFEFE 399 
4_pfamImport       294 KV-CDEDDM-RRIVNDHLLPLVGNQLRNFERKLEKMDQLLEEIASRTEQQLRRLFKFAQGSAHLWDVHEIGLAKQERKLQ 371 
jgi:MICPUN_104071  502 ARLDARRAEHERVDAAKEGAFDAACEDIAVAADEAKLEAAVDVAHQRLDDIELNYRDFNGAMGEIARSNPKSQSEAWEEY 581 
EEN65433           502 EKLEACRHSHDATNQDREANLDIVMDHMRQDSTEEALQNSLQQALTMLNIIKEGYELFHGQQVDIVKGYPSMVTEELTNY 581 
EKC33617           704 EKLEQCRQVHDNQNQDKEAHLDIIMDRMRQDATEKQLKDSLDKALDMLNKIKNAYEVFHTDQMDIVKNYPTMVKAEMKNY 783 
EGD78892           413 EKIHGLRSLLRQRQAETEQALDMKIDALRQAGSKDALAGLKRAVETHLTQAKKLLEEYGDSAKGVPTTHPTKIKAQAEAY 492 
EFJ43278           489 GALKQYREAFNAADAAREAALDAAVAAVTRGSGETQLDACVAEALKRLDDIEAGYRSFHREMTSRARAYPGAVRTANDAY 568 
XP_003057208       485 AELATQRAAFEARDAECENVFKEKVERMATAATEEDLDEMFNDANGTLDDIETNYRDLRANGTATAEKYPISQSEEWADY 564 
XP_001323276       384 TEQKTVDEQSTQLLDGYEQTLTQKTNEITTLVDAQKIKQCVDDCKQTLSKIEAEYREHYKKVLAIIEKQPGELVSIYESS 463 
A0DIZ4             470 IQKAQAADKNDEVLEELTKKLKENKQKLTEALHHPRLEECLAQCYKDLDLFGEEYERFHQDNLAIANQHPNIIRNKHQMF 549  Parameci...
EGR27437           400 LKKATAADENDEKLEKLNEEFEKIKFLLKQALHHPKLNELLEISFNKIDDIEKEYRDFHEKNIQIAKQQPILIQNLFLEY 479 
4_pfamImport       372 SELEQTRQVHDTDNQEREGKLDVCLDRLRQESNDEALSVCLQQCLEMLAYIKEGYEEFHNQQMEKVAEYPSMIAEELTKY 451 
jgi:MICPUN_104071  582 QRRLCLVLRLVPNVAPRP 599 
EEN65433           582 DAGLCRFFGVDRNPTGPS 599 
EKC33617           784 DEGVCKFFEVGRNQPKKS 801 
EGD78892           493 FERVEAILGVVRLSEKAA 510 
EFJ43278           569 HVNLCAELGVQPQIRLAG 586 
XP_003057208       565 QRKLCRMLRLVPNVPPKR 582 
XP_001323276       464 ETNMLTKLKMKKTANSTE 481 
A0DIZ4             550 EKSALSIFELVDPQKEQF 567  Paramecium tetraurelia
EGR27437           480 EKSILEYFELIPLSQKSQ 497 
4_pfamImport       452 DQLVCKFFNVDRNNPVDL 469 
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