Conserved Protein Domain Family

cd03172: SORL_classII (this model, PSSM-Id:28803 is obsolete and has been replaced by 239422)
Click on image for an interactive view with Cn3D
Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism against reactive oxygen species and are found in anaerobic bacteria and archeae, and microaerophilic Treponema pallidum. The SORL domain contains an active iron site, Fe[His4Cys(Glu)], which in the reduced state loses the glutamate ligand. Superoxide reductase (class II) forms a homotetramer with four Fe[His4Cys(Glu)] centers.
PSSM-Id: 28803
Aligned: 22 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 7-Nov-2005
Updated: 9-Mar-2011
Aligned Rows:
non-heme irontetramer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:non-heme iron binding site [ion binding site]
  • Comment:Each iron is coordinated to imidazole nitrogens of four histidines in a planar arrangement, with a cysteine ligand occupying an axial position.
  • Structure:1DQI; Superoxide reductase (SOR) in oxidized form.
    View structure with Cn3D
  • Comment:In two of the subunits of oxidized SOR, a Glu carboxylate serves as the sixth ligand to form an overall six-coordinate, octahedral coordinate environment.
  • Structure:1DQK; Superoxide reductase (SOR) in reduced form.
    View structure with Cn3D
  • Comment:The iron centers in all four subunits of reduced SOR exhibit pentacoordination.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1            # #                           #     #                                      
1DQI_A        9 GDWKGEKHVPVIEYEReg---elVKVKVQVGkeIPHPNTTEHHIRYIELYFLpegenfVYQVGRVEFTahgesvngpnts 85  Pyrococcus furiosus
YP_385557    52 KTPLEQKHAPVIKAPHavkagepFTVEVTVGe-QVHPMGPTHWIEYIELNVG------NEPAGRIAMQpr---------- 114 Geobacter metall...
AAR34050     51 KSPLEQKHVPVITAPKavkagepFTVEVAVGe-VVHPMGPTHWIQFIELNVG------NEPAGRVDMQpr---------- 113 Geobacter sulfur...
NP_988277    12 GTDFEKKHVPMIECKNsvkpdeiYEVKIHTAg-VEHPMEDGHFIQFIELNVE------EYPLLRVQLTq----------- 73  Methanococcus ma...
Q58151       13 GTDFEKKHTPFIECKDrvkandyFEVKISTG--IPHPMEDNHFIHWIELYMG------DLYLARVDFTq----------- 73  Methanocaldococc...
NP_618610    20 LTDGEKKHIPIINVPEtivagepFDVTVEVGi-IPHVMEEKHHIEWIELYLN------DKKIRRAELSle---------- 82  Methanosarcina a...
ZP_00562675  39 ITETEQKHVPVIEADEvmtaegsFEVTVKVGe-LPHVMQDEHYIEWIELSLG------DMKIGRVELSps---------- 101 Methanococcoides...
AAM07090     20 LTDGEKKHIPIINVPEtivagepFDVTVEVGi-IPHVMEEKHHIEWIELYLN------DKKIRRAELSle---------- 82  Methanosarcina a...
NP_632656    17 LTEGEKKHVPVIEAPEmviagrpFEVAVTVGs-IPHVMEEKHFIEWVELYLH------NKLVGRKELDp----------- 78  Methanosarcina m...
NP_247726    13 GTDFEKKHTPFIECKDrvkandyFEVKISTG--IPHPMEDNHFIHWIELYMG------DLYLARVDFTq----------- 73  Methanocaldococc...
Feature 1                                                             #  #       
1DQI_A       86 dvyTEPIAYFVLktk-----------------------------kkGKLYALSYCNIHGLWENEV 121 Pyrococcus furiosus
YP_385557   115 -gfLHPKVTFTVvipkea-----------------------apagkITLVAHQRCNLHGYWEGSL 155 Geobacter metallireducens GS-15
AAR34050    114 -gfLSPKATFTVtipkea-----------------------apegkITLVVNERCNLHGYWEGSI 154 Geobacter sulfurreducens PCA
NP_988277    74 --hSKPDVVVNIkapnee-----------------------hkgrtIKLVATMFCNLHGLWKYEK 113 Methanococcus maripaludis S2
Q58151       74 --fMKPEVKLMVkapsk-------------------------ehekFILRALMRCNLHGVWEYEK 111 Methanocaldococcus jannaschii
NP_618610    83 --nKKAEATFTVeadks------------------------lagkeSKLRALENCNIHGLWEEFM 121 Methanosarcina acetivorans C2A
ZP_00562675 102 --dEKAEATFTVepteeivgihayqvcn--ihgvnvcgkcgsksvvMKLDALISCNVHGLWESKK 162 Methanococcoides burtonii DSM 6242
AAM07090     83 --nKKAEATFTVeadks------------------------lagkeSKLRALENCNIHGLWEEFM 121 Methanosarcina acetivorans C2A
NP_632656    79 --sGEKVATVIFeveadealiaikeietcrvrgvnicgscgeksviANLRAVEKCNVHGIWEEYK 141 Methanosarcina mazei Go1
NP_247726    74 --fMKPEVKLMVkapsk-------------------------ehekFILRALMRCNLHGVWEYEK 111 Methanocaldococcus jannaschii D...

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