2EFG,1JQM,2XEX


Conserved Protein Domain Family
EF-G

?
cd01886: EF-G 
Click on image for an interactive view with Cn3D
Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so that it mimics the shape of a tRNA molecule. EF-G in the GTP form binds to the ribosome, primarily through the interaction of its EF-Tu-like domain with the 50S subunit. The binding of EF-G to the ribosome in this manner stimulates the GTPase activity of EF-G. On GTP hydrolysis, EF-G undergoes a conformational change that forces its arm deeper into the A site on the 30S subunit. To accommodate this domain, the peptidyl-tRNA in the A site moves to the P site, carrying the mRNA and the deacylated tRNA with it. The ribosome may be prepared for these rearrangements by the initial binding of EF-G as well. The dissociation of EF-G leaves the ribosome ready to accept the next aminoacyl-tRNA into the A site. This group contains both eukaryotic and bacterial members.
Statistics
?
PSSM-Id: 206673
Aligned: 61 rows
Threshold Bit Score: 394.166
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1             # ####                                                                  
2EFG_A     14 NIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHE.[1].AATMDFMEQERERGITITAAVTTCFW.[ 1].DHRINIIDT 84   Thermus thermophilus
CAA22530   30 NVGIIAHIDAGKTTLTEKMLYYGGFTSHFGNVDT.[1].DTVMDYLPAERQRGITINSAAISFTW.[ 1].NQRINLIDT 100  fission yeast
NP_012433  43 NIGIIAHIDAGKTTTTERMLYYAGISKHIGDVDT.[1].DTITDFLEQERSRGITIQSAAISFPW.[ 2].TFAINLIDT 114  baker's yeast
AAK29716   27 NIGVIAHVDAGKTTVTERLLYLAGAIHVAGHVDK.[1].NTVTDFLDIERERGITVQSAAVNLDW.[ 1].GHRINLIDT 97   nematode
NP_733781  72 NIGIMAHIDAGKTTTTERILYYSGYTRSLGDVDD.[1].DTVTDFMAQERERGITIQSAAVTFDW.[ 1].GYRVNLIDT 142  human
XP_448932  25 NIGIIAHIDAGKTTTTERMLYCAGKIKRIGDVDS.[1].DTVTDFLPQERDRGITIQSAAISFQW.[ 8].PRVINLIDT 102  Candida glabrata CBS138
XP_455710  25 NIGIIAHIDAGKTTTTERMLYYSGKINRIGDVDQ.[1].DTITDYLPQERSRGITIQSAAISFNW.[ 2].DYKINLIDT 96   Kluyveromyces lactis N...
XP_501982  17 NIGIIAHIDAGKTTTTERILYLSGTIKHLGNVDE.[1].DTTMDFLPAERERGITIASAATSFNW.[ 1].NHTVNLIDT 87   Yarrowia lipolytica CL...
EAL91882   71 NIGIIAHIDAGKTTTTERMLYYSGFTRRIGDVDE.[1].STVTDFLPAERARGITIQSAAITFHW.[19].SHTINLIDT 159  Aspergillus fumigatus ...
XP_718715  31 NIGIIAHIDAGKTTTTERMIYYSGRTKRIGNVDE.[1].DTVTDYLPSERERGITIQSAAITLPW.[ 1].QHKINIIDT 101  Candida albicans SC5314

Feature 1                                                            ## #                 
2EFG_A     85 PGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKY.[2].PRIAFANKMDKTGADLWLVIRTMQERL 157  Thermus thermophilus
CAA22530  101 PGHADFTFEVERSVAVLDGAVAIIDGSAGVEAQTKVVWKQATKR.[2].PKVIFVNKMDRVGSSLGSTIRSIYTNL 173  fission yeast
NP_012433 115 PGHIDFTFEVIRALKVIDSCVVILDAVAGVEAQTEKVWKQSKSK     PKICFINKMDRMGASFNHTVNDLINKF 185  baker's yeast
AAK29716   98 PGHVDFRVEVERCVRVLDGIVVVIDGSAGVQPQTLTVWRQSSKF.[2].PAHFFINKMDKLAANFENSVDSVEQKL 170  nematode
NP_733781 143 PGHVDFTLEVERCLRVLDGAVAVFDASAGVEAQTLTVWRQADKH.[2].PRICFLNKMDKTGASFKYAVESIREKL 215  human
XP_448932 103 PGHADFIFEVIRSLKVLDGAVLILDGVAGVEAQTEKLWRYSRNI     PKICFVNKMDRVGAGFSKTLKELTYKT 173  Candida glabrata CBS138
XP_455710  97 PGHADFTFEVIRSLKVLDSCVTILDSVAGVEAQTEKVWKQSSGL     PKICFLNKMDRVGAGFSRTVKELVVKM 167  Kluyveromyces lactis NRRL ...
XP_501982  88 PGHADFTFEVIRSIRVLDGAVCILDGVAGVEAQTEKVWKQASEM.[2].PKIAFVNKMDRAGAGFGRTVKEIVSKL 160  Yarrowia lipolytica CLIB99
EAL91882  160 PGHADFTFEVLRSLRILDGAVCILDGVAGVEAQTERVWHQASTY.[2].PRIVYVNKLDRDGAAFGRTVREVGSRL 232  Aspergillus fumigatus Af293
XP_718715 102 PGHADFTFEVIRSLRVLDGAVTILDAVAGVEAQTEKVWKQASAL.[2].PKVVYVNKMDRPGAGFSRTVQEVIQKL 174  Candida albicans SC5314

Feature 1                                                                                     
2EFG_A    158 .[3].PVVMQLPIG.[ 4].FSGIIDVLRMKAYTY.[ 6].DIREIP.[ 6].DNAREYHEKLVEVA.[4].ENIMLKYL 232  Thermus thermophilus
CAA22530  174 .[4].PLVLQLPVY.[ 8].FLGILDILQQKMILW.[10].GTHVQE.[ 8].ERFIEARNALVMSL.[4].ETLCDEYL 259  fission yeast
NP_012433 186 .[7].PVLVNIPYY.[10].FQGVIDVVNGKRLTW.[ 6].EIIVDE.[ 6].EQCNRCRESMIETL.[4].EDLVQHFL 270  baker's yeast
AAK29716  171 .[3].AVKLVVPLP.[ 5].NRGFLDILHSKMLPG.[ 6].NPPKNS.[ 3].ELLAEHKSELCFTL.[4].ADFQSKFL 243  nematode
NP_733781 216 .[3].PLLLQLPIG.[ 4].FKGVVDVVMKEKLLW.[ 6].GKDFER.[12].KETTEARNALIEQV.[4].DEFADLVL 296  human
XP_448932 174 .[3].CVVVNFPYF.[10].FCGVIDVINMKLLKW.[ 6].PDAVTV.[13].VEAIKSRESMVEIL.[4].DVFVQEFF 261  Candida glabrata CBS138
XP_455710 168 .[3].ALLINTPIF.[10].FSGVLDLIYGKQLIW.[ 6].KINVTD.[ 8].EYLVRGREALVETL.[4].ESIVEHFF 250  Kluyveromyces lactis N...
XP_501982 161 .[3].VALLTVPVF.[ 7].FEGVVDILNGCVITW.[ 5].GKQTVV.[11].EEYQKARTALVETL.[4].EELVEKFL 242  Yarrowia lipolytica CL...
EAL91882  233 .[3].PAVCQIPWF.[ 6].FVGVADAINLQGLRW.[ 6].VVKMLS.[12].KELRRARIALVELL.[4].EAMVEKFL 315  Aspergillus fumigatus ...
XP_718715 175 .[3].VVLCNLPYF.[ 9].FKGVIDVIHQKLLKW.[ 6].GNEISV.[11].QILEKSRESMVETL.[4].ERIIDSFL 259  Candida albicans SC5314

Feature 1                                   ###                     
2EFG_A    233 E.[ 6].EELVAAIRKGTI.[4].TPVFLGSAL.[3].GVQLLLDAVVDYLPSP 283  Thermus thermophilus
CAA22530  260 E.[ 9].DRLFKIIKQKTI.[4].VPVLCGSSL.[3].AVQPIMDAIIDYLPSP 313  fission yeast
NP_012433 271 E.[11].QFLNASIRKLTM.[4].VPVLCGASF.[3].GVQPLLDAIVNYLPSP 326  baker's yeast
AAK29716  244 D.[11].IEMKSVLRELTC.[4].ATISCGSAI.[3].KRRGQLSYMRIYTGSL 299  nematode
NP_733781 297 E.[11].EKLQTAIHRVTL.[4].VPVLCGSAL.[3].GIQPLLDAVTMYLPSP 352  human
XP_448932 262 D.[12].QVLNKSIRKLTI.[4].TPVLAGASF.[3].GIQPLLDGIIQYLPSP 318  Candida glabrata CBS138
XP_455710 251 N.[11].EVLNASIRKATI.[4].TPVLCGASF.[3].GVQPLLDAIANYLPSP 306  Kluyveromyces lactis NRRL Y-1140
XP_501982 243 E.[ 9].EDIKRALRTATI.[4].VPVLCGASF.[3].GVQPLMDAVVDFLPSP 296  Yarrowia lipolytica CLIB99
EAL91882  316 E.[10].QDILESLRRCLL.[7].VPIFAGASF.[3].GVQPLLDAVVNLLPSP 373  Aspergillus fumigatus Af293
XP_718715 260 E.[10].MLLDQVIRKATI.[4].TPVFCGASF.[3].GVQPLMDGITKYLPSP 314  Candida albicans SC5314

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap