Conserved Protein Domain Family
KH-I_HOW

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cd22466: KH-I_HOW 
type I K homology (KH) RNA-binding domain found in Drosophila protein held out wings (how) and similar proteins
How, also called KH domain protein KH93F, or protein muscle-specific, or protein Struthio, or protein wings held out (who), or Quaking-related 93F (qkr93F), is an RNA-binding protein involved in the control of muscular and cardiac activity. It is required for integrin-mediated cell-adhesion in wing blade. It plays essential roles during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization.
Statistics
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PSSM-Id: 411894
Aligned: 6 rows
Threshold Bit Score: 224.415
Created: 20-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative RNAGXXG motif
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure evidence that Homo sapiens Quaking protein (4JVH) binds RNA

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            # ### #####   #        #####   # #             #            
O01367       132 GSVVTMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDaNRGKPNWEHLSDDLHVLIT 211 fruit fly
EEC14144      69 GPPVSRSEKVYVPVKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDlNRGKPNWEHLNDDLHVLIT 148 black-legged tick
XP_002127447 152 GPTITLTEKVYVPVKDHPEYNFVGRLLGPRGLTAKQLEQETKCKIMVRGKGSMRDKKKEDlNRGKPNWEHLNDELHVLIT 231 vase tunicate
XP_027238261  67 GASVTLSDKVYVPVKEHPEFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEEqNRGKPNWEHLNEELHVLIT 146 Penaeus vannamei
EFX67278      93 GAAVNLSEKVYVPVKEFPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGRGSMRDKKKEEqNRGKPNWEHLNDELHVLIT 172 common water flea
G5EFF1       125 GDSTVHTEKVFVPAKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGRGSMRDKKKEElNRGKPNWEHLSEELHVLIQ 204 Caenorhabditis ...
Feature 1                                 
O01367       212 VEDTENRATVKLAQAVAEVQKLLVP 236 fruit fly
EEC14144     149 VEDSNNRADVKLQRAVDEVRKLLVP 173 black-legged tick
XP_002127447 232 VEDTDNRARVKMQRAMEEIQKLLIP 256 vase tunicate
XP_027238261 147 VEDTENRAKLKIQRAIEEIRKLLVP 171 Penaeus vannamei
EFX67278     173 VEDTENRAKVKLQRAVDEIRKLLVP 197 common water flea
G5EFF1       205 CEDTENRAKVKLMRAVEEVRKLLVP 229 Caenorhabditis elegans

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