first calponin homology (CH) domain found in plectin and similar proteins
Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It can also bind muscle proteins such as actin to membrane complexes in muscle. Plectin contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.
Feature 1:integrin binding site [polypeptide binding site]
Evidence:
Structure:4Q58; Homo sapiens plectin in complex with integrin beta 4 through its actin-binding domain, contacts at 4A.
Comment:The interaction between the integrin alpha6beta4 and plectin is essential for the assembly and stability of hemidesmosomes, which are junctional adhesion complexes that anchor epithelial cells to the basement membrane.
Jiyao W et al.(2023). "The conserved domain database in 2023.",