Conserved Protein Domain Family
CH_ASPM_rpt2
?
cd21224: CH_ASPM_rpt2 
second calponin homology (CH) domain found in abnormal spindle-like microcephaly-associated protein (ASPM) and similar proteins
ASPM, also called abnormal spindle protein homolog, or Asp homolog, is involved in mitotic spindle regulation and coordination of mitotic processes. It may also have a preferential role in regulating neurogenesis. Members of this family contain two copies of CH domain in the middle region. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.
Links
?
Statistics
?
PSSM-Id: 409073
Aligned: 37 rows
Threshold Bit Score: 125.491
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
 
putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   #                                                                           
Q8IZT6       1112 NIKLLMDWVNAVCAFYNk-kVENFTVSFSDGRVLCYLIHHYHPCYVPFDAIcqrttqtvectqtgsvvlnssse---sdd 1187 human
PRW61192      612 HAAALLSWVQAVCAHYDl-pVRTFGACFGDGSAFCLLIHHYLGHSYIALKDvyrsvqpveaa------------------ 672  Chlorella sor...
QDZ24099      690 VINLLLKWAQTICAGHGl-kIRNFTSSFADGHALCLIVNRYAPELLSLDSVqrvsaqgdd-------------------- 748  Chloropicon p...
XP_005647939  681 LLDLLLRWARTVCGRSGvivRDLAAGSFADGRALCYLVNFYLPWLLPAAHIchvpeqapadeddsesh------------ 748  Coccomyxa sub...
XP_002287403  683 IKRLLLVWCQVVCSFHGv-sVENFSTSFADGKVLCLLISFYLPSILPLQAIrptvsdlq--------------------- 740  Thalassiosira...
XP_003060781  807 HETMLLRWARAVCANYGv-aITDATTSFADGRALCALVHAYAPELLPLGLVknppagfdpsaaptaw------------- 872  Micromonas pu...
KAA6419435    561 RLAVLLSWCQAVCGAYGl-tVVNFRTSFADARGLCLLMSYYLPSYLSEEQIfvppraatdrlvmeayseqd--------l 631  Trebouxia sp....
PNW82494      815 ASQALLQWVRAACALHGv-gVDNFTWSLADGRALCYLVHTYLPEALPKSRIsvpdtpattdemarltggteyvkletlka 893  Chlamydomonas...
XP_024364413  680 VLDLLLSWVQAICVNVDgvtVQNFSTSFADGQVLCHLISNFLPDCLPCQAIripdnsalnvngdqsyq------------ 747  Physcomitrell...
OAE19890      669 TVELLLKWTQVVCMISGnlnIRNFRTSFADGQALCYIVNLYLPLFLAQEDVlrplchmnlqi------------------ 730  Marchantia po...

Feature 1                                 # ##  ## #          #########        # ## ##  ##  #   
Q8IZT6       1188 ssldmslkafdhentselyKELLENEKKNFHLVRSAVRDLGg--IPAMINHSDMSNt--iPDEKVVITYLSFLCARLL 1261 human
PRW61192      673 --------eksagwaggvsREQLEGARRNFTLVQGVVQSLGg--IPAMVSAEDFVEh--gYDEKGCILFTAFLCQRLL 738  Chlorella sorok...
QDZ24099      749 -----------vsrnapksEREIEQVRSNFTVMNECLSHLGg--VPRMLSFSDFDSy--gPDEIAVISFLAFLASRMM 811  Chloropicon primus
XP_005647939  749 ---fqrppwiavldegeqaGPRRAATHRNFELLAVATARLGg--VPPMLTADDCCApg-gPHEHAIIGYVGFLCARLL 820  Coccomyxa subel...
XP_002287403  741 -----------ittktgvkIAGYVHKKGNLALAMARMSEVGg--IPPLFSASDFLLp---PEEKAIILCLSFLFSRLT 802  Thalassiosira p...
XP_003060781  873 ---asarpdnpargvtrdaIVATAACEHNFDIVRGLCAALGdvpEPTFGPADVARGggggPDGKVVAGYLLFLCARLL 947  Micromonas pusi...
KAA6419435    632 afegtvgdidvssldeaarQTHIAGVKSNLHLAQAAALALGd--VPPILSAPGFLEh--gPDEKATVIFLSFLCARVL 705  Trebouxia sp. A1-2
PNW82494      894 ngwsavyemggvihddglaAAYKAAVAANFRALHAAGDALG---LPALLGAEDYLEd--gPDELAAILYVALLGEALM 966  Chlamydomonas r...
XP_024364413  748 ---ighsepqnflrcengsSRDRSAIVHNFQMVENAAELLGi--APEVLRLSDMVDgdscTSERNIIIFVAHLCSALL 820  Physcomitrella ...
OAE19890      731 --------dstpnlrgpfsPAYKKAVAHNFGLVQAVARKLGn--IPEVLQLVDLLGdp-aMSERNIIIFVAFLCSRLL 797  Marchantia poly...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap