6AYE,5WJ5


Conserved Protein Domain Family
ELD_TRPML

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cd21050: ELD_TRPML 
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)
TRPML family proteins contain a linker between the first two transmembrane helices (S1 and S2), which is called TRPML I-II linker. It forms a tight tetramer that is crucial for full-length TRPMLs assembly and localization. In lysosomes and endosomes, this linker faces the lumen (it is therefore also referred to as the 'luminal linker'); on the plasma membrane, it faces the extracellular solution. TRPML I-II linker has been named as extracytosolic/lumenal domain (ELD).
Links
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Statistics
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PSSM-Id: 410965
Aligned: 61 rows
Threshold Bit Score: 121.203
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:5WJ5; Homo sapiens TRPML1 extracytosolic/lumenal domain (ELD, also called TRPML I-II linker) forms a tetramer with a four-fold rotational symmetry; contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #   #### #               ########                                     #     
6AYE_A       114 RMDDTYAVYTQSDVYDQLIFAVNQYLQLyNVSVGNHAYENkgt--------------------kqsAMAICQHFYkrgni 173 human
XP_019849478 137 NKVNKLSLYNDEELNEDINFITDKYFQLpNITLGGYNHLLdsdg-------------------nmePITATVRQYqqidi 197 Amphimedon quee...
AXS78296     107 PSSGRYSVFTGPDIINQFAFMIDSYYMLqEESFASFSYDTslihrekrtlnetaavvnkisfdqipFLELCIHRIan--v 184 herring worm
XP_015786088 136 PGTGPYACYTRDDLDRNINNFVKAFANVtNSSLKTFAYDSsapd-------------------ivsPIYLEIIEFtkgee 196 two-spotted spi...
Q8IZK6       114 EDDYSCSVYTQEDAYESIFFAINQYHQLkDITLGTLGYGEned--------------------nriGLKVCKQHYkkgtm 173 human
XP_024506944 127 PSVGKYSVFTSTDLIEHFAFIINSYYSLhNDSFASFSYDIaltpynesifsgg-lrsinmdydkipPLQLCIEKLas--v 203 Strongyloides r...
XP_015784554 209 PSAGPFACYTKSDLFRNIDYAIRSFSNItNTGVGSFSYDSaapd-------------------kvsPIYVNILRFakgea 269 two-spotted spi...
5WJ5_A       112 GADDTFAAYTREQLYQAIFHAVDQYLALpDVSLGRYAYVRgggdp----------------wtngsGLALCQRYYhrghv 175 human
AAK19624     128 PAEGRYSVYDDQGLSEHLSFLINSYYSIrNDSFASFSYDVvshpsgnlg--------aqisfesipPIEVLIDRIsn--v 197 Caenorhabditis ...
XP_024499043 138 PSAGRYSVFDSSDILEHFAFATNAYYSIqNQTFASFSYDTswkgvsfvnst----itfqtpiydipPMSLCIEKIan--v 211 Strongyloides r...
Feature 1        ##  # #                                                          #   ##      ## 
6AYE_A       174 YPGNDTFDIDpEIETECFFVEPdepfhig-----------tpaenklNLTLDFHRLLTVELQFKLKAINLQtvrhqeLPD 242 human
XP_019849478 198 ESSSDSVVFNhNVITTEINIIEdsdpf----------------lqlmEEGFAWNQFIDATILLYLKKVHIVkn--pdRID 259 Amphimedon quee...
AXS78296     185 TVFNDTYEFDiSEIDGCFKLNFteeevqkvhnnswsleeilrvrgitFKPEDALIISKAELKFKLRTIHFSpvstdqRPE 264 herring worm
XP_015786088 197 NAFNFTFNFNnEIHTTNFTIKSdypagdvrwds----fsiqnflssqQYQFNFDSLIKMKLITNLKIIYRNsldfynFPE 272 two-spotted spi...
Q8IZK6       174 FPSNETLNIDnDVELDCVQLDLqdlskkp-----------pdwknssFFRLEFYRLLQVEISFHLKGIDLQtihsreLPD 242 human
XP_024506944 204 IIKNNTYEFDiKKETNCSKLIFtykelteindepsnlreilarrnvtFNANDSLVISKLVIHFNLRTIHYSpvlmdeNPE 283 Strongyloides r...
XP_015784554 270 DPFNFSYNFNnENTMDRYLIDLnytagdiewnh----fsikkflasqSYAINFDSLIQIQIVTSLRTIYLNaldsynRPQ 345 two-spotted spi...
5WJ5_A       176 DPANDTFDIDpMVVTDCIQVDPperpppppsdd---ltllessssykNLTLKFHKLVNVTIHFRLKTINLQslinneIPD 252 human
AAK19624     198 TVNNNTYNFDiREVKDTKRLNLtetevfqigqsddavrdilatrgitFLPEDALKISTVQFKFRLRTIHYSptagdqKPE 277 Caenorhabditis ...
XP_024499043 212 KINKNNYEFDiSSKKECKFLNYtsseviklrneplyikellakrnltLTPEESLSISKIFLMFNLRTIHYSpankdqTPE 291 Strongyloides r...
Feature 1                    # #####    ###      ##
6AYE_A       243 CYDFTLTITFDNKaHSGRIKISLDNDISIRe-CK 275 human
XP_019849478 260 CYLITITVLYSNEdHSGIIDRSLNFNFEFVs-CN 292 Amphimedon queenslandica
AXS78296     265 CYLIAVTITFDNSrHTGQVFISLSTEISYVnlCN 298 herring worm
XP_015786088 273 CYIIQISFVLDNSlHAGQVLMKLNTKSIQKq-CF 305 two-spotted spider mite
Q8IZK6       243 CYVFQNTIIFDNKaHSGKIKIYFDSDAKIEe-CK 275 human
XP_024506944 284 CYLIKVSIVYDNSrHTGQIGIDLKSVISYKniCN 317 Strongyloides ratti
XP_015784554 346 CYVVEIAITFDNSlHAGQLLMSLEAKRSYRp-CV 378 two-spotted spider mite
5WJ5_A       253 CYTFSVLITFDNKaHSGRIPISLETQAHIQe-CK 285 human
AAK19624     278 CYKISVSIKFDNSrHTGQVHVTLSTVVSYVnvCN 311 Caenorhabditis elegans
XP_024499043 292 CYLIKITISFDNSrHTGQVFIDLNSVISYEqiCN 325 Strongyloides ratti

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