extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)
TRPML family proteins contain a linker between the first two transmembrane helices (S1 and S2), which is called TRPML I-II linker. It forms a tight tetramer that is crucial for full-length TRPMLs assembly and localization. In lysosomes and endosomes, this linker faces the lumen (it is therefore also referred to as the 'luminal linker'); on the plasma membrane, it faces the extracellular solution. TRPML I-II linker has been named as extracytosolic/lumenal domain (ELD).
Structure:5WJ5; Homo sapiens TRPML1 extracytosolic/lumenal domain (ELD, also called TRPML I-II linker) forms a tetramer with a four-fold rotational symmetry; contacts at 4A.
Jiyao W et al.(2023). "The conserved domain database in 2023.",