2V5S,3DMK,4X8X,4X9H


Conserved Protein Domain Family
IgI_2_Dscam

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cd20953: IgI_2_Dscam 
Second immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
The members here are composed of the second immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. DSCAM is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.
Statistics
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PSSM-Id: 409545
Aligned: 7 rows
Threshold Bit Score: 175.808
Created: 17-Sep-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       ####                                                                           
2V5S_A     217 APRTPalv----qkPLELMVAHTISLLCPAQGFPAPSFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 292  fruit fly
3DMK_A     246 VPKVVsla---kfdMKTYSGSSTMALLCPAQGYPVPVFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 322  fruit fly
4X8X_A     215 RPKVNpqd---khqFIDVELASSYSLLCMAQSYPTPSFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 291  fruit fly
4X9H_A     218 SPQLSgngnqehitLTRVPKMGSVTLMCPAQAYPVPFFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 297  fruit fly
NP_724542  246 PPKINalt----ykPNIVESMASTAILCPAQGYPAPSFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 321  Drosophila melan...
ACC65887   226 APRFPtes---sssTLKKSSSISINLLCPAQAYPAPLFRWYKYVEGSTAKQPVKLDDRVKQVSGTLIIKEAKVEDSGKYL 302  Daphnia magna
NP_724544  246 SPKISggr----lqEITKSAATDLAILCLGQSFPTPAFRWYKFIEGTTRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYL 321  Drosophila melan...
Feature 1                        
2V5S_A     293 CVVNNSVGGESVETVLTV 310  fruit fly
3DMK_A     323 CVVNNSVGGESVETVLTV 340  fruit fly
4X8X_A     292 CVVNNSVGGESVETVLTV 309  fruit fly
4X9H_A     298 CVVNNSVGGESVETVLTV 315  fruit fly
NP_724542  322 CVVNNSVGGESVETVLTV 339  Drosophila melanogaster
ACC65887   303 CNVNNSVGGESVETVLTV 320  Daphnia magna
NP_724544  322 CVVNNSVGGESVETVLTV 339  Drosophila melanogaster

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