Conserved Protein Domain Family
C1_DGKtheta_typeV_rpt1
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cd20803: C1_DGKtheta_typeV_rpt1 
first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase theta, also called diglyceride kinase theta (DGK-theta), is the only isoform classified as type V; it contains a pleckstrin homology (PH)-like domain and an additional C1 domain, compared to other DGKs. It may regulate the activity of protein kinase C by controlling the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DAG kinase theta contains three copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410353
Aligned: 27 rows
Threshold Bit Score: 88.9033
Created: 4-Oct-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #            #  #              #  #    #  #        #     
P52824         60 GHSFRKVTLTKPTFCHLCSDFIWGL---AGFLCDVCNFMSHEKCLKHVRi-PCTSVAP 113  human
OXB66126       39 GHSFRRVTLTKPTFCHYCTDFIWGL---AGYQCEVCNFMSHEKCLKNVNi-PCSCIAP 92   scaled quail
NP_508191      20 GHYFVKKTFGKPAYCHHCCDKIWGMl-tTGYSCEMCNFVCHEKCLRTVVs-YCSSVAL 75   Caenorhabditis elegans
TSK87390       67 GHSFRKVTLTKPTFCHHCSDFIWGL---VGYVCEVCNFMSHEKCLKHVRt-VCSCMAP 120  goonch
XP_014352777   56 GHSIRKVTLTKPTFCHHCTDFIWGL---IGYQCEVCSFMSHEKCLKHVKt-LCSCMAP 109  coelacanth
VVC30520        6 GHVFTKKTFHLPAYCHNCTNLLWGVv-tQGNFCTVCNYIAHESCLKKPGisPCHSLAA 62   Cinara cedri
VDL17655       68 GHSFYRKSLSKPAYCHHCSEVIWGPl-sTGFACDVCNFLAHEKCLRDIVt-VCPAYAA 123  Hymenolepis diminuta
CCD58700       42 GHSFVKKNLHKPATCHHCSDLLWGIlgtTGMVCEVCNFLAHEKCMRSVVt-ACTCIAP 98   Schistosoma mansoni
CCD75754       85 GHSFIRRTLHKPAYCHHCGEVIWGIl-sSGFQCEICNLLAHERCQTVVSs-PCTSVAP 140  Schistosoma mansoni
XP_019901510   44 GHCFRKVTLTKPTFCHNCSDFIWGI---IGFICEVCELHAHSDCAMFTCg-DCRVCHQ 97   northern pike

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