3L2C,1E17


Conserved Protein Domain Family
FH_FOXO4

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cd20062: FH_FOXO4 
Click on image for an interactive view with Cn3D
Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins
FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.
Statistics
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PSSM-Id: 410836
Aligned: 8 rows
Threshold Bit Score: 176.049
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ## #  ###                 #   #                ##  #  ## ##  #      #        ## 
3L2C_A        21 RNAWGNQSYAELISQAIESApekRLTLAQIYEWMVRTVPYFKDKGDSNSsaGWKNSIRHNLSLHsKFIKVHNeatGKSSW 100 human
1E17_A        37 RNAWGNQSYAELISQAIESApekRLTLAQIYEWMVRTVPYFKDKGDSNSsaGWKNSIRHNLSLHsKFIKVHNeatGKSSW 116 human
P98177        98 RNAWGNQSYAELISQAIESApekRLTLAQIYEWMVRTVPYFKDKGDSNSsaGWKNSIRHNLSLHsKFIKVHNeatGKSSW 177 human
XP_006003804  78 RNAWGNQSYAELISQAIESSpdkRLTLSQIYDWMVKSVPYFKDKGDSNSsaGWKNSIRHNLSLHnKFIRVHNeatGKSSW 157 coelacanth
XP_007892293 114 RNAWGHQSYADLITKAIESSpdkRLTLSQIYEWMVKSVPYFRDKGDSNSsaGWKNSIRHNLSLHsKFIRVHNeatGKSSW 193 elephant shark
KYO41007      39 RNAWGNQSYAELISQAIDSApdkRLTLAQIYEWMVRSVPYFKDKGDSNSsaGWKNSIRHNLSLHsKFIKVHNeatGKSSW 118 American alligator
CAG09785      74 RNAWGNQSYADLISQAIENSpekRLTLAQIYEWMVKTVPYFRDKGDTNSsaGWKNSIRHNLSLHnKFLRVHNestGKSSW 153 spotted green p...
OCT67372      88 RNAWGNQSYAELISQAIESSpekRLTLSQIYDWMVKSIPYFKDKGDSNSsaGWKNSIRHNLSLHsKFIKVHNeatGKSSW 167 African clawed ...
Feature 1        #     
3L2C_A       101 WMLNPE 106 human
1E17_A       117 WMLNPE 122 human
P98177       178 WMLNPE 183 human
XP_006003804 158 WMLNPE 163 coelacanth
XP_007892293 194 WMLNPE 199 elephant shark
KYO41007     119 WMLNPE 124 American alligator
CAG09785     154 WMLNPE 159 spotted green pufferfish
OCT67372     168 WMLNPE 173 African clawed frog

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