Conserved Protein Domain Family
Bbox2_MYCBP2
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cd19799: Bbox2_MYCBP2 
B-box-type 2 zinc finger found in Myc-binding protein 2 (MYCBP2) and similar proteins
MYCBP2, also termed protein associated with Myc (Pam), is an atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues. MYCBP2 harbors a B-box motif that shows high sequence similarity with B-Box-type zinc finger 2 found in tripartite motif-containing proteins (TRIMs). The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380857
Aligned: 26 rows
Threshold Bit Score: 56.6332
Created: 12-Sep-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C H C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #          #  #                     #  #    #          #         
O75592       4259 PMCDNHDDGetaAIILCNVCGN------------------LCTDCDRFLHLHrrt---ktHQRQVFKEEE 4307 human
KYQ90436     3348 NTCQNHEDNiteAYVHCENCQMn-----------------LCNECDRFLHLPkkn---rdHTKSPLINDT 3397 Tieghemostelium lacteum
XP_001748055 4001 SFCDNHDDGettALVKCGECQAs-----------------FCADCDHVLHLSrtk---rdHVRVRLTTQQ 4050 Monosiga brevicollis MX1
XP_004996577 3803 FLCQHHDDGvtaAAVFCHTCHAh-----------------YCTYCDKFAHLHpsk---rnHERKDIDQIE 3852 Salpingoeca rosetta
Q17551       3334 LLCENHDDGhtvAQVFCVDCDVa-----------------LCKECFTVMHLHkkn---rnHGVKNLVQSS 3383 Caenorhabditis elegans
AAF76150     4809 PLCSNHDDGetaAIIQCETCGS------------------LCGDCDRFLHLNrkt---rsHKRTVCKEEE 4857 fruit fly
EFX74318     4251 PQCNNHDDGetgAQIVCSDCGP------------------LCIDCDRVLHLSrkf---rsHQRQVCKEEE 4299 common water flea
ANE21809      657 KMCTNHDDEstiATVICYTCQPisnatdptdlslsarlifLCAECDRYLHLSkmt---kyHIRDNLNIQP 723  Schmidtea mediterranea
XP_004993111 5097 PTCDNHGDDt-mAVVHCEECDLd-----------------LCRECDAFWHLPank---rsHKRIHMKPPP 5145 Salpingoeca rosetta
XP_642696       8 LKCQQHDKL---VTIYCCACDAy-----------------FCKKCDKEKHSQddnqedslHIRGLVNKDV 57   Dictyostelium discoideu...

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