2WZM,4OTK


Conserved Protein Domain Family
AKR_AKR5H1

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cd19134: AKR_AKR5H1 
Click on image for an interactive view with Cn3D
AKR5H family of aldo-keto reductase (AKR)
Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Statistics
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PSSM-Id: 381360
Aligned: 7 rows
Threshold Bit Score: 457.01
Created: 18-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2WZM: Mycobacterium smegmatis aldo-keto reductase in complex with the ligand, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                                                             
2WZM_A     12 PTVTLNDDNTLPVVGIGVGelSDSEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIpRDEIYVTTKLATpdqGF 91  Mycobacterium smeg...
4OTK_A     47 PSITLNDEHTMPVLGLGVAelSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGVaREELFVTTKLATpdqGF 126 Mycobacterium tube...
A5U6Y1     11 PSITLNDEHTMPVLGLGVAelSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGVaREELFVTTKLATpdqGF 90  Mycobacterium tube...
A0QV09     12 PTVTLNDDNTLPVVGIGVGelSDSEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIpRDEIYVTTKLATpdqGF 91  Mycobacterium smeg...
B2HIJ9     10 PSIALNDENTMPVLGMGVAglSDDETERAVSAALEIGCRLIDTAAAYGNEAAVGRAIAASGIpRAELFVTTKVATadhGF 89  Mycobacterium mari...
A1T726      8 PTVILNDDNTMPVIGLGVGelSDAEAEQSVLAALEAGYRLIDTAAAYGNEAAVGRAIAKSGVpRGELFVTTKLATddlGF 87  Mycobacterium fort...
OFV73856    6 PTVVLADGRLMPAIGLGVWqmTDEVASGSASAAIAAGYRLIDTASMYANEQGVGAAIRKSEIpRGELFVTTKVWNsdhGY 85  Rhodococcus erythr...
Feature 1                                                                                     
2WZM_A     92 TSSQAAARASLERLGLDYVDLYLIHWPGGdtsKYVDSWGGLMKVKEDGIARSIGVCNFgAEDLETIVSLtyFTPAVNQIE 171 Mycobacterium smeg...
4OTK_A    127 TRSQEACRASLDRLGLDYVDLYLIHWPAPpvgKYVDAWGGMIQSRGEGHARSIGVSNFtAENIENLIDLtfVTPAVNQIE 206 Mycobacterium tube...
A5U6Y1     91 TRSQEACRASLDRLGLDYVDLYLIHWPAPpvgKYVDAWGGMIQSRGEGHARSIGVSNFtAENIENLIDLtfVTPAVNQIE 170 Mycobacterium tube...
A0QV09     92 TSSQAAARASLERLGLDYVDLYLIHWPGGdtsKYVDSWGGLMKVKEDGIARSIGVCNFgAEDLETIVSLtyFTPAVNQIE 171 Mycobacterium smeg...
B2HIJ9     90 TASREACKASLDRLGLDYVDLYLIHWPAPaagKYVDAFGGLIQARGEGFTRSIGVSNFtEEHVSNVIDLtfVTPAVNQVE 169 Mycobacterium mari...
A1T726     88 QSSQDALRASLERLGLDYVDLYLIHWPAGsqgTYVDSWGGLMKLKELGLTRSIGVSNFhAQHLDDIIGLsfFTPAVNQIE 167 Mycobacterium fort...
OFV73856   86 DATIAACRRSLANLGLEYIDLYLIHWALAregKYVDTFRALLALRAEGLIRSVGVSNFtTVHLTELLNNtgEMPVVNQIE 165 Rhodococcus erythr...
Feature 1                            #######  #                #              # ###   #  ##   
2WZM_A    172 LHPLLNQAALREVNAGYnIVTEAYGPLGVGrlLDHPAVTAIAEAHGRTAAQVLLRWSIQLGNVVISRSANPERIASNLDV 251 Mycobacterium smeg...
4OTK_A    207 LHPLLNQDELRKANAQHtVVTQSYCPLALGrlLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDV 286 Mycobacterium tube...
A5U6Y1    171 LHPLLNQDELRKANAQHtVVTQSYCPLALGrlLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDV 250 Mycobacterium tube...
A0QV09    172 LHPLLNQAALREVNAGYnIVTEAYGPLGVGrlLDHPAVTAIAEAHGRTAAQVLLRWSIQLGNVVISRSANPERIASNLDV 251 Mycobacterium smeg...
B2HIJ9    170 LHPLLNQDELRKANAQHnVVTQSYTPLALGqlADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIATNLDV 249 Mycobacterium mari...
A1T726    168 LHPLLNQAELRAVNAEHgIVTEAYSPLGVGslLSNPAVTAIADAQDRTPAQVLIRWSLQLGNVVISRSSSPERIKSNLDV 247 Mycobacterium fort...
OFV73856  166 LHPRMAQRQMRDFHAKYgIVTQAWSPLGHGtaLEANEILRLAAKHCRAPAQIVLRWHLQNGVTALPKSSNPERIAANLQI 245 Rhodococcus erythr...
Feature 1                           #
2WZM_A    252 FGFELTADEMETLNGLDDGTRFR 274 Mycobacterium smegmatis str. MC2 155
4OTK_A    287 FDFELAAEHMDALGGLNDGTRVR 309 Mycobacterium tuberculosis
A5U6Y1    251 FDFELAAEHMDALGGLNDGTRVR 273 Mycobacterium tuberculosis H37Ra
A0QV09    252 FGFELTADEMETLNGLDDGTRFR 274 Mycobacterium smegmatis str. MC2 155
B2HIJ9    250 FEFELASQHMDAINGLNDGTRLR 272 Mycobacterium marinum M
A1T726    248 FDFELTADQMAALDGLDEGTRFR 270 Mycobacterium fortuitum complex
OFV73856  246 FDFELDSSDMGAIDALDIGERIG 268 Rhodococcus erythropolis

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