Conserved Protein Domain Family
BACK_KLHL22
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cd18461: BACK_KLHL22 
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)
KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.
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Statistics
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PSSM-Id: 350536
Aligned: 7 rows
Threshold Bit Score: 189.971
Created: 5-Oct-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q53GT1       147 VDEENILDVYRLAELFdLSRLTEQLDTYILKNFvaFSRTDKYRQLPLeKVYSLLSSNRLEVsCETEVYEGALLYHYSLEQ 226 human
XP_005987260 148 VDNENLLEMYKLADLFgLTHLSDQLDSYILKNFpsFSKTETYRQLPLnKVYSLLCSQRLEVnSENEVYEAALHYHYTPEQ 227 coelacanth
Q08CY1       147 VDEENVLELYKLADIFhLNRLTEQLDTFVLKNFitFSQTQMYRQLPLdKVFSLLNSNRLEVaSENEVYEGALLYHYTPEQ 226 western clawed ...
XP_007908273 139 IDNDNILALYELAELYsLTQLSDKIDSYILQNFlsFSKTETYRQMPLkKVQTLLSSDKLWInSESEVYEAALLYNYTPEE 218 elephant shark
XP_003199199 145 LDDDNILEVEKLADIYgLHQLGEKIRSYLLKNIqtFSRTPVYRKLPAeKVLSVLCSNELEVdSENEVYEAALHYHYTPEQ 224 zebrafish
KYO31632     133 VDEENILDMYKLADLFdLRHLSEQLDSYILKNFvtFSKTETYRQLSLeKVYTLLSSNCLEVsCENEVYEGALLYHYTPEQ 212 American alligator
XP_016081468 147 VDEENILDVYRLAGLFhLAHLADQLDAYVLGHFpaFCRSPAYRRLPPdKVRSLLGSDRLRVdSEREVLTGVLLYHFPPEV 226 platypus

Q53GT1       227 VQaDQISLHEPPKLLETVRFPLME 250 human
XP_005987260 228 IErDEVSLEEPPKLLETVRFPLME 251 coelacanth
Q08CY1       227 LEkDQVSLLESPKLLEAVRFPLMD 250 western clawed frog
XP_007908273 219 IEkDQVSLQDPPKLLQMVRFALIE 242 elephant shark
XP_003199199 225 VEkDQVCLQEPLRMLEAVRFCLME 248 zebrafish
KYO31632     213 LEtDQVSLMEPPKLLETVRFPLME 236 American alligator
XP_016081468 227 ADaGRVPPAVPPDLLDAVRFPLMD 250 platypus
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