2QBY,3PVS


Conserved Protein Domain Family
HLD_clamp_RarA

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cd18139: HLD_clamp_RarA 
helical lid domain of recombination factor protein RarA
Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.
Statistics
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PSSM-Id: 350841
Aligned: 81 rows
Threshold Bit Score: 38.767
Created: 13-Nov-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2QBY; Sulfolobus solfataricus Orc1 complex with bound ATP; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                            ##  #                       
2QBY_B       197 YDAEQLKFILSKYAEygl----------ikGTYD-DEILSYIAAISakehGDARKAVNLLFRAAQLasg-------ggiI 258 Sulfolobus solf...
YP_001255066 152 LNREDIILGLEKAINklid-------kginIKYT-FESLEYISEICq---GDYRKAYNILELAVNShcgf------nieI 214 Clostridium bot...
P40151       297 LNVNELCIVLSRGIAllnkcrkqvwnienpLKLS-RSILEYVVDLSv---GDTRRALNMLEMIEVStrerk---adeeeL 369 Saccharomyces c...
Q9HHZ9       183 YHENELIPILHDRVHwgl----------eeDVIS-DSHLQLIAANAg---GDARVVIGILRHSARTaret-----gsdqI 243 Halobacterium s...
YP_004889359 151 LSDTDIEIALRRAVTdiyn--------ltdDQVD-AKALNLIAISAe---GDLRIALNILETLHAIdq---------kqI 209 Lactobacillus p...
YP_193953    151 IKAEDIELVLIKAAEeh-----------lnFDLP-KKQAHAIANSGn---GDVRVSLNILDTLNAMhp---------qnI 206 Lactobacillus a...
O51974       195 YHDEQLHDILAARVKggl----------dqDVIT-TNQLDRIADAAa---GDARLAIGILRTAASKadre-----srerI 255 Halobacterium s...
Q975X3       208 YNAEELEDILKRRATlaf---------ydsVVSD-DVIKLCAAIAArd-hGDARRALDLLRVAGEVaerd-----gaekL 271 Sulfolobus toko...
NP_349245    265 LDAEEIKIIAKNAVEki------------nVNID-SKALELIAMYS----SNGRDVINLIQLACGIvine-----nrgrI 322 Clostridium ace...
O75943       290 VAPTIMMKFLNRIVTieank------nggkITVPdKTSLELLCQGCs---GDIRSAINSLQFSSSKgennlrprkkgmsL 360 human
Feature 1                  
2QBY_B       259 RKEHVDKAIV 268 Sulfolobus solfataricus
YP_001255066 215 NLDYIESLAQ 224 Clostridium botulinum
P40151       370 SIDDVRDIIK 379 Saccharomyces cerevisiae S288c
Q9HHZ9       244 TADLIEEVTP 253 Halobacterium salinarum
YP_004889359 210 TVAAVQHFAQ 219 Lactobacillus plantarum
YP_193953    207 SMANIEEFAR 216 Lactobacillus acidophilus
O51974       256 TDDILLNAAE 265 Halobacterium sp. NRC-1
Q975X3       272 TIEHVNKARV 281 Sulfolobus tokodaii
NP_349245    323 EAEDILWIAE 332 Clostridium acetobutylicum
O75943       361 KSDAVLSKSK 370 human

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