Conserved Protein Domain Family
SpoU-like
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cd18098: SpoU-like 
SAM-dependent rRNA or tRNA methylase related to SpoU
RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349971
Aligned: 19 rows
Threshold Bit Score: 163.588
Created: 8-Aug-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative SAM
Feature 1:putative SAM binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other SPOUT methylases
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
CCQ72178    5 FGIGSEGIHKPYNVGALMRTAHAFGaSFVYTVAasydr---pkggrTDTSKaHGHVPFYSFPDVKSLLlpe------dcK 75  Magnetospira sp. QH-2
AEE19724   11 FGIGIQNGKTPENLGVLWRSAQNLGaSFIFTIGnrya------kqsSDTHNaVKAMPYYHYDTFDDFFkhlp----kgvR 80  Krokinobacter sp. ...
EKF28127  170 VFVAVENPKTPANLGGILRAIGCFGfSGLIFSGtrllaa-lkhrpvTDTQAaGFSSPYVAIPDMINLFevlegatsfetV 248 Trypanosoma cruzi ...
NP_233016   7 VIIGLHNPKSPTNVGAVMRAAGCYNaTQVRYNGtryar---avkfqTDTQNsHERIGLVEMDDLTAGLds-------evK 76  Vibrio cholerae O1...
GAK33300   15 FAIGIERPSKVGNIGNLIRTAHGFGaAYVFSILarlepgelahqshADTARsARSVPYFEYTALDQLAlpk------gcQ 88  alpha proteobacter...
AFK57574   10 FAIGLEAVTRPMNAGTLFRAAHAFGaSYAFALSddrlg---rraaqADTSAsARHLPFFRFASIDALPmpe------gaL 80  Tistrella mobilis ...
EIK45789    6 AFIGLVNPKSPANVGMIMRAAGCYEaSGVFYTGerfdr---arkfsADTKNaASKICLQHVDQLEDAAqtgal--aegaV 80  Cellvibrio sp. BR
ABG40751   30 VALCIINPKSPQNMGSILRAAGCYGaDTIYYTGeryar---arafnTDTKNvGLNIPVEQVTTPEPAPg---------iA 97  Pseudoalteromonas ...
EEE06885   30 AAIGLHQPKDPKNIGGVLRAAGCYD-AALVVLSgrry-----qrasTDTQKaFRHLPVIQTDDVLSAIpv-------gaV 96  Burkholderia multi...
AHF91385    7 LAVGLHDPKMMKNIAGVLRACGCYEaAMLAVSGtryr------rhrCDTIKhWKSMPMLEVEDLRTVLay-------gcT 73  Opitutaceae bacter...

Feature 1        # #                                     ####  #             ## #  ## #  #    
CCQ72178   76 LVGVELlddaIDLPSFHHPp------------------NAAYILGPERgSLSPEMVArcdyTLKIPTRfCINVGLAGALV 137 Magnetospira sp. QH-2
AEE19724   81 IVGVELddraETLETFHHPr------------------RCVYLLGAEDhGLTNEAIEkshfLIKFPSTlSLNVSVAGSIV 142 Krokinobacter sp. ...
EKF28127  249 VVAVDMidgaTPLPLYRHPclhaldgvarkrrrctlpnLVVYLFGPEDgSIRQEVIArchsAVFLPTQgSLNLAAAVNVV 328 Trypanosoma cruzi ...
NP_233016  77 IVCVELavgaTALPHFTHPe------------------QAIYLFGPEDgSLPQEVVDqahyVVYVPTHgCMNLAATVNVV 138 Vibrio cholerae O1...
GAK33300   89 LVGVEItdeaIDLPSFHHPl------------------NAAYIMGGERmSLSAETCArcdhLIRIPTRfSLNVATAGAIV 150 alpha proteobacter...
AFK57574   81 LIGFEIddalDTMPYIPHPd------------------QAVYLIAPEVdGLSAAARSrasaVIRLPGRlALNPAMAGALV 142 Tistrella mobilis ...
EIK45789   81 LVAIELiegaTPLMDFIHPe------------------NAYYIFGPEDgSLKKDIIEqcqhVVYIPTIgCMNLAATVNVL 142 Cellvibrio sp. BR
ABG40751   98 MVAVELvegaTPLPHFRHPk------------------HAYYVFGPEDgSIEQSVLDrcqhVVYVPTKgCMNLAATVNVL 159 Pseudoalteromonas ...
EEE06885   97 PIAVEFtttaTPLTDFKHPe------------------SAFYIFGPEDgSVPNQIVAkcrdVVYVPTAyCMNLAAAVNVL 158 Burkholderia multi...
AHF91385   74 PVAVDLvpgaVSLVDYKHPa------------------RAFYIFGAEDgTLDDSVLAwctaRVMVPTRtCMNLASCVNVV 135 Opitutaceae bacter...

Feature 1         
CCQ72178  138 MYDR 141 Magnetospira sp. QH-2
AEE19724  143 LYDR 146 Krokinobacter sp. 4H-3-7-5
EKF28127  329 LYDR 332 Trypanosoma cruzi marinkellei
NP_233016 139 LYDR 142 Vibrio cholerae O1 biovar eltor str. N16961
GAK33300  151 MYDR 154 alpha proteobacterium Q-1
AFK57574  143 MYDR 146 Tistrella mobilis KA081020-065
EIK45789  143 LYDR 146 Cellvibrio sp. BR
ABG40751  160 LYDR 163 Pseudoalteromonas atlantica T6c
EEE06885  159 LYDR 162 Burkholderia multivorans CGD2
AHF91385  136 LYDR 139 Opitutaceae bacterium TAV5

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