2I6D,1GZ0,1IPA,1X7O,3NK7


Conserved Protein Domain Family
SpoU-like_rRNA-MTase
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cd18095: SpoU-like_rRNA-MTase 
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SAM-dependent rRNA methylase related to SpoU-TrmH
RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349968
Aligned: 324 rows
Threshold Bit Score: 97.1119
Created: 15-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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SAM bindingdimer interface
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:3NK7; Streptomyces actuosus NHR with bound SAM, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2I6D_A    104 LTLLLDGVQDPGNVGTILRTADWFGiRHVWLGTgsad-----vfspKVVQASXGALARVQPTPLkntVDTLAYFRrq--- 175 Porphyromonas ging...
3NK7_B    120 DVVVLDGVKIVGNIGAIVRTSLALGaAGIVLVDsdlat----iadrRLLRASRGYVFSLPVVLAd-rEEAVSFLRdn--- 191 Streptomyces actuosus
GAM26991   94 PIIVVLDNMEMDNVGPIIRSCASFGvRTVISLNqsllsngesiispSRYLTSRGAMEYVDIVETpsiTKLGDILMefkvy 173 Acytostelium subgl...
AEB13302  102 DAVILDRVGNANNLGAIVRSAAFFGiKNIVIPLdesqs----sittSSYRVAEGGMEFVNIYSVrsiPFLLKDMKgk--- 174 Treponema succinif...
CAM74543   99 PLVILDGIGNPHNLGAIARTMAFFGlGRLIVSDhpeqa----lpsdAAFRIAEGGLEWVDVYQVanlGKALPRLKph--- 171 Magnetospirillum g...
Q73J63    101 HVLMLDEIGNANNLGAIIRSAAFFGiENIVLTKedkqa----sittSAYRVAQGGMEFVKIFKVsstAWFLRQCRgr--- 173 Treponema denticola
EIP99003   98 PLLLLDRIGNAHNVGAIARSAAFFGvEHLVIPSraeaa----lpgeAAHRVAEGGLEHVTIWRVpdlARLCGELRea--- 170 Opitutaceae bacter...
O83093    118 FVVLLDRVGDAHNLGAIIRSAAFFGvHSLVVSDcrqqa----qvtsATYRVAQGGMEFVQLLRCtnaQEVLEMCAgk--- 190 Treponema pallidum
EHL96489  116 LLPVLDGIGNPHNLGAIARSAAFFGcKGMLLSGdprqa----glsdSAWRTSEGGLEALTLLRTsdlPVALGALApr--- 188 Acetobacteraceae b...
AFM12993   92 STLCLHDVKNPHNVGAILRTTAFFGvRDVIFSRksyda----amtaSAWRVAEGGVSLTHCYVYedaHDLFSRAKml--- 164 Turneriella parva ...

Feature 1           # #                                          ####  #             ## #     
2I6D_A    176 giPVYGAFLd----------------------GQSLYEaplpnftePAILVLGSEGrGISPEVAAeitdRLTIPASglsv 233 Porphyromonas ging...
3NK7_B    192 diALMVLDTd---------------------gDLGVKDlgd--radRMALVFGSEKgGPSGLFQEasagTVSIPMLss-- 246 Streptomyces actuosus
GAM26991  174 gwEIISIIGrernapl---------sifsddsIKSLGTk-------PLIVLLGSDGkGISSTLLRltdkDIHVPSYvi-- 235 Acytostelium subgl...
AEB13302  175 -mARFGTSLkaq------------------kkVSEMKLlcq---ekPALVVLGNEEkGISEEVAQncdsLVIIPFAgmge 232 Treponema succinif...
CAM74543  172 -yQVIGTALgah------------------rsMKDTFSsn----dkPLALVLGNEEeGLPATTLAacddIVTIPGSgr-- 226 Magnetospirillum g...
Q73J63    174 -lTCIGTDLrah------------------heIADLGRlie--kdeACVIVLGNEErGISEEAKKlcvhLIKIKGSgn-- 230 Treponema denticola
EIP99003  171 gyEVIGAAAhggtlrpdeakpargpargsgsrMPDAGPgprg-grpLRALVLGNEEhGLAPEVAAactrLVTIPGSgr-- 247 Opitutaceae bacter...
O83093    191 -mTRVGASPhafr---------------sltrLSNILSpe-----eAVILVLGNEEtGLSEHLTAhcdhLCRIAGSgq-- 247 Treponema pallidum
EHL96489  189 -fLTVAAVArgg------------------eaPEAILAsgd---arDIALVLGNEEeGLAEPTIAacarRVTLPGSgl-- 244 Acetobacteraceae b...
AFM12993  165 gwWCAAAVRpekg---------------rlpsLESICVrag---raHVVACLGNEEeGLPGAFVAgcgyKFTILGSgs-- 224 Turneriella parva ...

Feature 1           ## #  #        
2I6D_A    234 -kghtESLNVAIATAILCSEW 253 Porphyromonas gingivalis W83
3NK7_B    247 ----tESLNVSVSVGIALHER 263 Streptomyces actuosus
GAM26991  236 ----nGGLNASQSISIILSEC 252 Acytostelium subglobosum LB1
AEB13302  233 agpkvDSLNVAQAASVIMYEL 253 Treponema succinifaciens DSM 2489
CAM74543  227 ----vQSLNVSATAAILIHLL 243 Magnetospirillum gryphiswaldense MSR-1
Q73J63    231 ----vESLNVAQAATLFCHSL 247 Treponema denticola
EIP99003  248 ----vESLNVSAAAAVLMFAL 264 Opitutaceae bacterium TAV1
O83093    248 ----vESLNVAQAGALFLSTI 264 Treponema pallidum
EHL96489  245 ----vESLNVSVAAAVLMHAL 261 Acetobacteraceae bacterium AT-5844
AFM12993  225 ----vESLNVSVTAALCLEKM 241 Turneriella parva DSM 21527

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