Conserved Protein Domain Family
DEXHc_ATRX
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cd18068: DEXHc_ATRX 
DEXH-box helicase domain of ATRX
Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350826
Aligned: 5 rows
Threshold Bit Score: 442.02
Created: 3-Feb-2014
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Saccharomyces cerevisiae Chd1 with bound gamma-thio-ATP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #######                                    #
NP_000480 1560 LKPHQVDGVQFMWDCCcesvkktkkspGSGCILAHCMGLGKTLQVVSFLHTVLlcdkl--dfstALVVCPLNTALNWMNE 1637 human
NP_956947 1114 LKPHQVDGVQFMWDCCcesvrkveksaGSGCILAHCMGLGKTLQVVTLLHTVLlcekl--nfstALVVCPLNTVLNWLNE 1191 zebrafish
NP_651398  455 LKPHQVAGVKFMWDACfetlkesqekpGSGCILAHCMGLGKTLQVVTLSHTLLvntrr-tgvdrVLIISPLSTVNNWARE 533  fruit fly
Q9U7E0     463 LKPHQAHGIQFMYDCAcesld-rldteGSGGILAHCMGLGKTLQVITFLHTVLmhekigekckrVLVVVPKNVIINWFKE 541  nematode
XP_420305 1488 LKPHQVDGVQFMWDCCcesvkktktspGSGCILAHCMGLGKTLQVVSFLHTVLlcdkl--nfrtALVVCPLNTALNWLNE 1565 chicken

Feature 1                                                                                      
NP_000480 1638 FEKWqeglkdd-eklevsELATVKRPqers--ymlqRWQEDGGVMIIGYEMYRNlaqgrnvksr----------klkeif 1704 human
NP_956947 1192 FEKWqeglkde-eslevtELATVKRPqera--yalqRWQEDGGVMIMGYEMYRNltqgrniksk----------klketf 1258 zebrafish
NP_651398  534 FTSWmkfanr--ndievyDISRYKDKptri--fklnEWFNEGGVCILGYDMYRIlanekakglr---------kkqreql 600  fruit fly
Q9U7E0     542 FQKWlvdndeeldtidvnELDSYKTIedrrralkawHSSKTPSVMIIGYDLFRIltveddpkkkkpknrnrrlekakedf 621  nematode
XP_420305 1566 FEKWqegledd-eklevcELATVKRPqers--ymlqRWQDEGGVMIIGYEMYRNlaqgrnvksr----------klkeif 1632 chicken

Feature 1                    ##                                                                
NP_000480 1705 nkaLVDPGPDFVVCDEGHILKNeaSAVSKAMNSIRsRRRIILTGTPLQNNLiEYHCMVNFIKENLLGsikefrNRFINPI 1784 human
NP_956947 1259 qktLVDPGPDFVICDEGHVLKNeaSAVSKAMNSIKtRRRVVLTGTPLQNNLiEYHCMVNFIKENLLGsvkefrNRFINPI 1338 zebrafish
NP_651398  601 mqaLVDPGPDLVVCDEGHLLKNekTSISKAVTRMRtKRRIVLTGTPLQNNLrEYYCMIQFVKPNLLGtykeymNRFVNPI 680  fruit fly
Q9U7E0     622 rkyLQNPGPDMVVCDEAHKLKNddSALSKCMVKILtKRRICLTGTPLQNNLmEYHCMVNFVKPGLLGtktefaNRFVNII 701  nematode
XP_420305 1633 nkaLVDPGPDFVVCDEGHILKNeaSAVSKAMNSIRsRRRIILTGTPLQNNLiEYHCMVNFIKENLLGsikefrNRFINPI 1712 chicken

Feature 1                         
NP_000480 1785 QNGQCADstmvDVRVMKKR 1803 human
NP_956947 1339 QNGQCADstlvDVRVMKKR 1357 zebrafish
NP_651398  681 TNGQYTDsterDLRLMKHR 699  fruit fly
Q9U7E0     702 NRGRTKDasplEVSFMKRR 720  nematode
XP_420305 1713 QNGQCADstlvDVRVMKKR 1731 chicken

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