4BE7,2W00,4BEC,4BEB,4XJX


Conserved Protein Domain Family
DEXHc_RE_I_HsdR
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cd18030: DEXHc_RE_I_HsdR 
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DEXH-box helicase domain of type I restriction enzyme HdsR subunit
The HdsR motor subunit of type I restriction-modification enzymes contains the DNA cleavage and ATP-dependent DNA translocation activities of the heteromeric complex. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350788
Aligned: 37 rows
Threshold Bit Score: 220.947
Created: 12-Jul-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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ATP bindingDEAD box
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:4BE7; Escherichia coli HsdR with bound Mg.ATP, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ####  #                                            
4BE7_B        253 LLNVLVNysVFDSSq------------tLLVMRPYQIAATERILWKIKssftak-----------------------nws 297  Escherichia coli
ADL42114      274 ILDLLHTftIFKEDpks--------kmiKVVARYQQFRAVKKMIKRLKegk----------------------------t 317  Caldicellulos...
NP_716018     286 FLDILQNfiIFEPVegk---------liKKVARYQQYRAVNKVIERLKtgq----------------------------d 328  Shewanella on...
YP_001635422  245 FLTLIRDfiVFEDDgsg--------rlvKKMAGYHQFHAVLVAVKETLrasavvssnrmaesg----gvyeagrepggkp 312  Chloroflexus ...
ADN12727      238 LLDILQSfiVFETDgdt---------itKKLAGYHQYHAVNKAITATLeath--------------------------pq 282  Cyanothece sp...
EFV08871      235 LLDIICNfiVFEKEqirdlngilsikttKKIACYHQYYAVNKAISRTItass--------------------------kd 288  Campylobacter...
ABV20607      243 LLDVIRHfiVFEASkhedskgiisirtvKKMAAYHQYYAVNAAVLSTIrasgvnadspsaevalrqqgrnskvlvnaqkt 322  Escherichia c...
BAD24840      246 LLDLIRYfvLFQDDgkg--------hisKILAAYHQYYAVNKAVDRALlass--------------------------gq 291  Staphylococcu...
Q60295        284 LIEFLEDfiIHDKK--------------KIIATYYQFYTVKKAVDRTIksvlyg-----------------------etp 326  Methanocaldoc...
ABG84559      267 LLDLMRNfiVFEAEdgv---------viKKVCRYQQFRAVNKALNKIKngk----------------------------d 309  Clostridium p...

Feature 1                    #######                                                              
4BE7_B        298 kpESGGYIWHTTGSGKTLTSFKAARLATeld--fidKVFFVVDRkDLDYQTMKEYQRFs---------PDSVNGSE--NT 364  Escherichia coli
ADL42114      318 pnERGGIVWHTQGSGKSLTMMFMVRELYhnpefgnyKVVFVTDRkDLEKQLNETSRSVg---------FTVKLARSiqEL 388  Caldicellulos...
NP_716018     329 rkEKSGVVWHTQGSGKSLTMVMLAVKMRrdpvlkqyKLVFITDRtQLDEQLSSTFRAAq--------gETIYNAGSvaEL 400  Shewanella on...
YP_001635422  313 gdRRIGVVWHTQGSGKSLTMVFYAGCIIrkpamenpTIVVLTDRnDLDDQLFNTFSRCqdl-----lrQPPVQAESrvHL 387  Chloroflexus ...
ADN12727      283 gdKKVGVVWHTQGSGKSLTMAFYAGKIIqqpemanpTLVILTDRnDLDDQLFNTFSLCtdl-----lrQTPTQAESreQL 357  Cyanothece sp...
EFV08871      289 gdKKGGVVWHTQGSGKSLSMVFYSAKAIkal--nnpTILLITDRnDLDDQLFGTFASCanl-----lrQEPKQANDkeHL 361  Campylobacter...
ABV20607      323 gdRKAGVVWHTQGSGKSLSMVFYTGKIVlal--nnpTVVVITDRnDLDDQLFGTFSSAtql-----lrQTPKQADNreEL 395  Escherichia c...
BAD24840      292 gdGKGGVIWHTQGSGKSLTMVFFSGKLIqml--nnpTLVVVTDRnDLDNQLYSTFVKSkgrsgkgllrQTPKQAETrkEL 369  Staphylococcu...
Q60295        327 edRRIGIVWHAQGTGKSITMLFYAKKALkqkelnypLLVFLTDRlELDEQLYNVFSSVf---------SEAERAESiaEL 397  Methanocaldoc...
ABG84559      310 kiSRGGVVWHTQGSGKSLTMVFLARKIKrtqgltdsTIVIVTDRiDLDKQIAGTFERTlg------kiTTPVRADTidKM 383  Clostridium p...

Feature 1                                                                                         
4BE7_B        365 AGLKRNLdkddnKIIVTTIQKLNNLMKaesdl----------------pvynqQVVFIFDECHRSQ-------------- 414  Escherichia coli
ADL42114      389 KELLKTDt---pELVMAMVYKFQEKELkgefpv---------------lntspNILIMIDEAHRTQ-------------- 436  Caldicellulos...
NP_716018     401 KALLKKDs---sDLVTAMVQKFLDLEKelstnnene--------gfinlnpsdKIIVLADEAHRTQ-------------- 455  Shewanella on...
YP_001635422  388 RQLLSVQs---gGIVFTTIQKFLPEEKgdrhpv---------------lsnrrNIVVITDEAHRSQyd------------ 437  Chloroflexus ...
ADN12727      358 QELLKVAs---gGVIFTTIQKFSPEYGnqypl----------------lsnrrNIILIADEAHRSQygleakvi------ 412  Cyanothece sp...
EFV08871      362 KELLRVAs---gGVVFTTIQKFSPENDnvfec----------------lslrdNIIVIADEAHRTQygfdakvveeksks 422  Campylobacter...
ABV20607      396 KEYLRVAs---gGVVFTTIQKFQPNDGsniyel---------------lsdrtNIVVIADEAHRSQygfsakevdvkdse 457  Escherichia c...
BAD24840      370 KSLLSVEs---gGIIFTTMQKFEPEQNettmaa---------------lterkNVIVMADEAHRTQygfnaky------- 424  Staphylococcu...
Q60295        398 QELIKKTp---gGIIFATIQKFGRKSKdehypf---------------ltdrnNIIIIADEAHRSH-------------- 445  Methanocaldoc...
ABG84559      384 KKLLSNPq---pQIIMTTIQKFQSETEekevmldgenltqkyaveypvlstkqNIIVLADEAHRSQ-------------- 446  Clostridium p...

Feature 1                                                                  
4BE7_B        415 --------FGEAQKNLKKKFKRYYQFGFTGTPifpenalgseTTASVFGreLHSYVI 463  Escherichia coli
ADL42114      437 --------YKLLGANLRKALPNATKIAFTGTPi--------eKTEMTFGdyIDKYSI 477  Caldicellulosiruptor obsidiansis OB47
NP_716018     456 --------FGGLAMTINAALPNAPKIGFTGTPllk-----tqKMDKAFGgyIDEYKI 499  Shewanella oneidensis MR-1
YP_001635422  438 -------fIDGFARHMRDALPQASFIGFTGTPiek----adaDTRAVFGdyISIYDI 483  Chloroflexus aurantiacus J-10-fl
ADN12727      413 nkqeeayiSYGFAKYLRDALPNASFIGFTGTPiea----gdiNTPAVFGdyIDIYDI 465  Cyanothece sp. PCC 7822
EFV08871      423 gdvlgqkiVYGFAKYLRDALPNATYIGFTGTPies----hdiNTPAVFGnyIDIYDI 475  Campylobacter jejuni subsp. jejuni 305
ABV20607      458 gnvtgkrtVYGFAKYMRDALPNATYLGFTGTPiek----tdvNTPAVFGnyVDIYDI 510  Escherichia coli E24377A
BAD24840      425 -ddkgegiKYGYAKYLRDALPNATFVGFTGTPvas----tdkNTQMVFGnyIDVYDM 476  Staphylococcus aureus
Q60295        446 --------YGTLAQNLRKAIPNASFLAFTATPidy----kdrSTFLVFGdyISAYPI 490  Methanocaldococcus jannaschii DSM 2661
ABG84559      447 --------YKDTAANMRKALPNAVFIGFTGTPidk----edkSTPRTFGgyIDKYSI 491  Clostridium perfringens ATCC 13124

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