Conserved Protein Domain Family
DEXHc_RecQ3
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cd18017: DEXHc_RecQ3 
DEAH-box helicase domain of RecQ3
DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Links
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Statistics
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PSSM-Id: 350775
Aligned: 5 rows
Threshold Bit Score: 342.14
Created: 20-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Escherichia coli RecQ with bound Mg.gamma-thio-ATP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ###  #                   #######                                     
Q14191        537 VTCLKMyfgHSSFKPVQWKVIHSVLeeRRDNVAVMATGYGKSLCFQYPPVyvgkIGLVISPLISLMEDQVLQLKMsniPA 616  human
EAT45563       12 LAALEShfgHSNFRPMQWTIIRSIIedRRDNCVIMATGYGKSLTYQYPSVflqrLTLVISPLISLMEDQVLSLNLsniPS 91   yellow fever ...
ADY41874       45 LDKLNKyfgHKSFRPLQWEIIRNALe-RKDQLVVMSTGYGKSICYQMPSLlkdnLTLIVSPLISLMNDQVTNASAngiAA 123  pig roundworm
Q19546        216 LNALNEffgHKGFREKQWDVVRNVLg-GKDQFVLMSTGYGKSVCYQLPSLllnsMTVVVSPLISLMNDQVTTLVSkgiDA 294  nematode
NP_001081838  478 ISCLKTyfgHSSFKPVQWKVVHSVLreRRDNLVVMATGYGKSLCYQFAPVytsgIGIVICPLISLMEDQVLQLEMsniSS 557  African clawe...

Feature 1                                                                  ##                     
Q14191        617 CFLGSAqsenvlt----diklgkyRIVYVTPEYc--sGNMGLLQQleadigiTLIAVDEAHCISEWGhDFRDSFRKLGSL 690  human
EAT45563       92 CLLGSAqranpvp----dikagkfRVVYLTPEYvtgeSGKYLLEQvan--qlVLIAIDEAHCLSKWGhDFRPAYRNLGVI 165  yellow fever ...
ADY41874      124 SCITGEtqredrnevfedclngrlRLLYVTPEFg--lNNPELIRKisl--riGLLAIDEAHCVSQWGhEFRSDYRCLSSI 199  pig roundworm
Q19546        295 VKLDGHstqiewdq--vannmhriRFIYMSPEMvtsqKGLELLTScrk--hiSLLAIDEAHCVSQWGhDFRNSYRHLAEI 370  nematode
NP_001081838  558 CFLGSAqsknvlq----dvkdgkmRVIYMTPEFc--sRGISLLQDldnrygiTLIAIDEAHCISEWGhDFRSAYRSLGSL 631  African clawe...

Feature 1                        #                           
Q14191        691 KTal--pmVPIVALTATAsSSIREDIVRCLnlrnPQITCTGFD 731  human
EAT45563      166 RKwc--prVPILAVTATAtPNVRDDIVTSLglwnPQVLCTGFD 206  yellow fever mosquito
ADY41874      200 RDii--gdVPLMALTATAtPEVKKDIIKNLhmrqAVTLCTSLD 240  pig roundworm
Q19546        371 RNrsdlcnIPMIALTATAtVRVRDDVIANLrlrkPLITTTSFD 413  nematode
NP_001081838  632 KRml--pnVPIVALTATAsPSIREDITKSLnlhnPQVTCTSFD 672  African clawed frog

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