Conserved Protein Domain Family
DEXHc_CHD1L
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cd18006: DEXHc_CHD1L 
DEAH/Q-box helicase domain of CHD1L
Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350764
Aligned: 5 rows
Threshold Bit Score: 354.822
Created: 3-Feb-2014
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Saccharomyces cerevisiae Chd1 with bound gamma-thio-ATP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #######                                 #           
XP_003216901   36 LHPYQLEGVNWLThc-yGTWHGCILGDEMGLGKTCQTISLLLVLSGKLn-kRPFLVLCPLSVLNNWKEELNRFAPr-LSF 112  green anole
Q7ZU90         35 LRPYQLDGVKWLSlc-mKNQQGCILGDEMGLGKTCQTISLLAYARGSLkmnGPFLVLCPLAVLENWRQELERFCPs-LSV 112  zebrafish
Q86WJ1         46 LRSYQLEGVNWLAqr-fHCQNGCILGDEMGLGKTCQTIALFIYLAGRLndeGPFLILCPLSVLSNWKEEMQRFAPg-LSC 123  human
ADY41136       15 LRPHQVSGVETVLsw-rAEGHGGIIADEMGLGKTCEAISVLWILAKTEk-lRPHLIICPLSVVDHWEKELKRFGCddLKY 92   pig roundworm
AEC10492       51 LKPHQVEGVSWLIqkylLGVNVVLELDQMGLGKTLQAISFLSYLKFRQglpGPFLVLCPLSVTDGWVSEINRFTPn-LEV 129  thale cress

Feature 1                                                              ##                         
XP_003216901  113 ITYWGDKEERTELQQdifs---nnnFHILLTTYEICLKDASFLKRFNWACLVVDEAHRLKNEdSLLHKTLSEFSt-DFCL 188  green anole
Q7ZU90        113 ICYTGDKEKRAELQQnlks---dprFHVLLTTYEMCLKDARYLKSWKWKILVVDEAHRLKNQeSLLHQTLKEFTv-GFRV 188  zebrafish
Q86WJ1        124 VTYAGDKEERACLQQdlkq---esrFHVLLTTYEICLKDASFLKSFPWSVLVVDEAHRLKNQsSLLHKTLSEFSv-VFSL 199  human
ADY41136       93 IKFMGDLEKRLDLCRqirt---tndWNVLLTTYEYVLIEGSPIAKFHWASLVFDEAQRIKNTnSMLHAAIQQLSv-DWTI 168  pig roundworm
AEC10492      130 LRYVGDKYCRLDMRKsmydhghflpFDVLLTTYDIALVDQDFLSQIPWQYAIIDEAQRLKNPnSVLYNVLLEQFliPRRL 209  thale cress

Feature 1                                                                             
XP_003216901  189 LLTGTPIQNSLKELYALLTFIEPvifpkdlaeKFVHYYHEvkkes------ktaqELHSLLKPFLLRR 250  green anole
Q7ZU90        189 LLTGTPIQNNLQEVYSLLTFIQPsvflpeaveDFVNAYADiqtep------alvdELHQVLQPFLLRR 250  zebrafish
Q86WJ1        200 LLTGTPIQNSLQELYSLLSFVEPdlfskeevgDFIQRYQDiekes------esasELHKLLQPFLLRR 261  human
ADY41136      169 LMTGTPIQNSMQELFALLSVIDKnkfpldkldRFIKKYSKtddd-------gvveELRLTLSKYMIRR 229  pig roundworm
AEC10492      210 LITGTPIQNNLTELWALMHFCMPlvfg--tldQFLSAFKEtgdgldvsndketykSLKFILGAFMLRR 275  thale cress

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