Conserved Protein Domain Family
DEXHc_DHX34
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cd17979: DEXHc_DHX34 
DEXH-box helicase domain of DEAH-box helicase 34
DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350737
Aligned: 6 rows
Threshold Bit Score: 287.032
Created: 18-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human RNA helicase A (DHX9) with bound Mn.ADP
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #                        #######                             #                  
NP_001121459  154 LPIFQYKEKIISMVHkHQVVVVAGDTGCGKSTQVPQYLLAAGfgHIACTQPRRIACISLAKRVGFEslnqygsKVGYQIR 233  western clawe...
NP_728244     146 LPIARFRKDLREALDtSRVVIVAGDTGCGKSTQVPQYLYDFGyrSIACTQPRRLACVSLCKRVAHEllddygsRVAFQIR 225  fruit fly
NP_001121805  162 LPIFQYRDKIVELVRtHPVVVVAGDTGCGKSTQVPQYLLASGinNIACTQPRRIACISLAKRVSFEslnqygsKVGYQIR 241  zebrafish
ADY41048      133 LPIAAHREHIIDVISkNQVLIIAGDTGCGKSTQVPQYLLEANfdRIACTQPRRIAATALARRVAFEtldeygsSIAYQIR 212  pig roundworm
Q14147        162 LPIAQYGNRILQTLKeHQVVVVAGDTGCGKSTQVPQYLLAAGfsHVACTQPRRIACISLAKRVGFEslsqygsQVGYQIR 241  human
NP_001294374  144 LPIAERAGEIVELLKtNQVLIVAGDTGCGKSTQVPQYLLKAGftGVACTQPRRIACTALARRVAYEtlnqygsEVAFQIR 223  Caenorhabditi...

Feature 1                                              ##                                         
NP_001121459  234 FESSRSpatKIVFITEGLLLRQIqrdstlpqyQVIIVDEVHERHlhsDFLLGVLRQLLIlrpdLKVILMSATinIKLFSG 313  western clawe...
NP_728244     226 FERSRTkltNILFITEGLLLRQLavaanldqyDALILDEIHERNlfgDFLLGVTKCLLRarpqLKLILMSATinVELFHG 305  fruit fly
NP_001121805  242 FETSRTlatKLLFLTEGLLLRQIqqdaslgqyQVLIVDEVHERHlhcDFLLGVLRSLLSlrpdLRLVLMSATinIKLFSS 321  zebrafish
ADY41048      213 FERTRTlrtRLLFLTEGLLLRQMqidadllqhNVIILDEIHERNlsgDFLMGLLRELIRrradLKLILMSATinLELFTS 292  pig roundworm
Q14147        242 FESTRSaatKIVFLTVGLLLRQIqrepslpqyEVLIVDEVHERHlhnDFLLGVLQRLLPtrpdLKVILMSATinISLFSS 321  human
NP_001294374  224 FETTKSqktKLLFLTEGLLLRQMekdsllekyNVIILDEVHERHltsDLLIGLLRDLCTkrddLKLILMSATinLDLFKG 303  Caenorhabditi...

Feature 1                     
NP_001121459  314 YFeq--aPVLQV 323  western clawed frog
NP_728244     306 YFgeegaRLVQV 317  fruit fly
NP_001121805  322 YFnd--aPVLQV 331  zebrafish
ADY41048      293 YFag--aPVIEV 302  pig roundworm
Q14147        322 YFsn--aPVVQV 331  human
NP_001294374  304 YFeg--aPVVQV 313  Caenorhabditis elegans

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