ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3 (MAP1LC3)
Autophagy is an essential intracellular process that targets large protein complexes, bacterial pathogens, and organelles for degradation. MAP1LC3 (also known as LC3) has a ubiquitin-like (Ubl) fold and belongs to the ATG8 autophagy protein family. A Ubl conjugation of MAP1LC3 by the phospholipid phosphatidylethanolamine (PE) is an essential process for the formation of autophagosomes. MAP1LC3 is cleaved by the cysteine protease ATG4 and is then conjugated with PE by E1-like enzyme ATG7 and ATG3, an E2-like enzyme. The Ubl conversion of MAP1LC3 is known as a marker of autophagy-induction. This sub-family includes MAP1LC3A, MAP1LC3B, and MAP1LC3C, each encoded by a different MAP1LC3 gene.
Feature 1:Atg13 interaction site [polypeptide binding site]
Evidence:
Comment:LC3-Atg13 interaction site
Comment:Autophagy is a bulk degradation process that degrade cytosolic materials to maintain cellular homeostasis. Atg13 and LC3 proteins are required for making autophagosome.
Structure:3WAO; Homo sapiens LC3 interacts with ATG13 LIR, contacts at 4A.
Jiyao W et al.(2023). "The conserved domain database in 2023.",