3FXH


Conserved Protein Domain Family
IGCP_Hfx_cass2
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cd12842: IGCP_Hfx_cass2 
integron gene cassette protein (IGCP) Hfx_cass2 and similar proteins
This family contains the unique integron gene cassette protein Hfx_cass2 and similar proteins that have yet to be characterized. The structure of Hfx_cass2 depicts a homodimer incorporating a compact all-alpha fold of six helical segments with a core central bundle of helices. It has a surface cleft reminiscent of an enzyme active site. This family may allow an assessment of the impact of the integron/gene cassette system on the emergence of new phenotypes, such as drug resistance or virulence.
Links
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Statistics
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PSSM-Id: 410985
Aligned: 13 rows
Threshold Bit Score: 157.541
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Integron Gene Cassette Protein Hfx_cass2 forms a homodimer
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #  ##  ## ##                                                            
3FXH_A        24 NKHATSAVHEIIREICRLVDsgHSXTrDQFHELSEQerFIAFLAEKYss-tIKLYYLadssplfekDTSSFIENAFGRHA 102 uncultured bact...
CAP48202      12 NKHATSAVHEIIREICRLVDsgHSMTrDQFHELSEQerFIAFLAEKYss-tIKLYYLadssplfekDTSSFIENAFGRHA 90  uncultured bact...
WP_029882044   5 AEKLRDGCQWLSRELTRLEQlnRPLTiDEFYSWSEQenFIGTIFEKYrhhiIGLEMLdpksdyckkDILGFIENALARHT 84  Enterobacter
WP_023296447   5 AEKLRDGCQSLTRELTRLEQlnRPLSlDEFYSWTERenFVSTIFDKYrsyiIALDVLdpksercdgNLLSYIENALGRHS 84  Enterobacter ho...
WP_045340946   5 AEKLRDGCQSLTRELTRLEQlnRPLSlDEFYSWTERenFVSTIFDKYrsyiIALDVLdpksercdgNLLSYIENALGRHS 84  Enterobacter ho...
WP_025204082   5 AENLRDGCQWFSRELTRLEQlnRPLSiDEFFSLTEQqiFIKTMFKRYgdyiIGLQTLdpesdhcnvDLLDYIEDALGRHT 84  Enterobacter lu...
WP_047356397   5 AENLRDGCQWFSRELTRLEQlnRPLSiDEFFSLTEQqiFIKTMFKRYgdyiIGLQILdpesdrcnvDLLDYIEDALGRHT 84  Enterobacter sp...
WP_023136421   5 AEQLRDGCQWLSRELTRLEQlnRPLSiDEFFDLSEDekFINTMFEKYghfiLGLHLLdhrsehcnkELIAYLENALSRYS 84  Salmonella ente...
WP_036971541   5 PELLRDGCQWLARELTRLEQlnQPLSiNDFFSWSSNeaFIKTIFTRYrefiKGLYILdheseyycvELTEYMENALARHE 84  Proteus mirabilis
WP_019210803   5 AEQLRDASQWLIRELTRLSQlnRPLTlDEFYQFSENeiFIHELFENYwefiRGLHVLdpskdthnkELLEYMENAFCRHA 84  Yersinia massil...
SKC22493       5 AVYLRDTCQMIVLELTRLQQlnLPLSiEQFYEWSEKekFITTILKKYghfcRALSELkldsahfqsEMLSYIENAYSRHS 84  Kosakonia radic...
WP_131681040   5 KRYLSDSCQLLSVELTRLEQlgLPFSlDEFYSWSLSgeFIESFFKQYgayiQGLHELnpsnddckkELIECINHSFEMMS 84  Providencia ret...
WP_152551527   3 DKNAVSAVHEVIRELCRLIDsgSFMKrNQFHELSEQerFVAFLIEEFsq-tVRFDYLadssplfekDIFLFVENAFGRHA 81  Polycyclovorans...

Feature 1               ######  #  ##  #   #   
3FXH_A       103 NTvvxedFGLKSNALLLAINICLAILREIN 132 uncultured bacterium
CAP48202      91 NTvvmedFGLKSNALLLAINICLAILREIN 120 uncultured bacterium
WP_029882044  85 NVitsgtYGVVDNAYLLAINVLFAISREAD 114 Enterobacter
WP_023296447  85 NVitsatYGVVDNAYLLAINVLFSISREAD 114 Enterobacter hormaechei
WP_045340946  85 NVitsatYGVVDNAYLLAINVLFSISREAD 114 Enterobacter hormaechei
WP_025204082  85 NVitsgtYGVVENAYLLAINVLFSIAREAD 114 Enterobacter ludwigii
WP_047356397  85 NVitsgtYGVVENAYLLAINVLFSIAREAD 114 Enterobacter sp. GN02730
WP_023136421  85 NVitrdtYGVVDNAYLLAINVLFDISREAD 114 Salmonella enterica
WP_036971541  85 NVitpevYGVVDNAYLLAINVVFSIAREAD 114 Proteus mirabilis
WP_019210803  85 NAitpktYGVVDDAYLLAINVAASISREAD 114 Yersinia massiliensis
SKC22493      85 NVitpetYGVTDDAYLLAINVAFAISREAD 114 Kosakonia radicincitans
WP_131681040  85 QIinkemFGITDSAYLLAIHYLILIMTDEG 114 Providencia rettgeri
WP_152551527  82 NVvvmedFGLRSNSLLLAINICVAILRELQ 111 Polycyclovorans algicola

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