3SDE,3SDE,5CA5,4WII


Conserved Protein Domain Family
RRM1_p54nrb_like

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cd12332: RRM1_p54nrb_like 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 (RRM1) found in the p54nrb/PSF/PSP1 family
This subfamily corresponds to the RRM1 of the p54nrb/PSF/PSP1 family, including 54 kDa nuclear RNA- and DNA-binding protein (p54nrb or NonO or NMT55), polypyrimidine tract-binding protein (PTB)-associated-splicing factor (PSF or POMp100), paraspeckle protein 1 (PSP1 or PSPC1), which are ubiquitously expressed and are conserved in vertebrates. p54nrb is a multi-functional protein involved in numerous nuclear processes including transcriptional regulation, splicing, DNA unwinding, nuclear retention of hyperedited double-stranded RNA, viral RNA processing, control of cell proliferation, and circadian rhythm maintenance. PSF is also a multi-functional protein that binds RNA, single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and many factors, and mediates diverse activities in the cell. PSP1 is a novel nucleolar factor that accumulates within a new nucleoplasmic compartment, termed paraspeckles, and diffusely distributes in the nucleoplasm. The cellular function of PSP1 remains unknown currently. This subfamily also includes some p54nrb/PSF/PSP1 homologs from invertebrate species, such as the Drosophila melanogaster gene no-ontransient A (nonA) encoding puff-specific protein Bj6 (also termed NONA) and Chironomus tentans hrp65 gene encoding protein Hrp65. D. melanogaster NONA is involved in eye development and behavior, and may play a role in circadian rhythm maintenance, similar to vertebrate p54nrb. C. tentans Hrp65 is a component of nuclear fibers associated with ribonucleoprotein particles in transit from the gene to the nuclear pore. All family members contain a DBHS domain (for Drosophila behavior, human splicing), which comprises two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a charged protein-protein interaction module. PSF has an additional large N-terminal domain that differentiates it from other family members.
Statistics
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PSSM-Id: 409769
Aligned: 14 rows
Threshold Bit Score: 113.16
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #                                              #  ##  ##                 
3SDE_A     22 RCRLFVGNLPtditEEDFKRLFERYGEPSEVFINrDRGFGFIRLEsRTLAEIAKAELdg--tiLKSRPLRIRF 92  human
Q04047    301 RNRLYVGNLTnditDDELREMFKPYGEISEIFSNlDKNFTFLKVDyHPNAEKAKRALdg--smRKGRQLRVRF 371 fruit fly
XP_798086 107 RCRLFVGNLAndisESDFKKMFEKYGEVSETFLNsQKGFGFIRLDtRLNAEAAKAALdg--tqQKNRTIRVRF 177 purple urchin
CBY20926  114 QSRLFVGGLPeaitQEQVRQMFQKFGEVKEVYIPqGKTFAFIKMTnRMQADQAKYGLsgktiaGQNRPIRVKF 186 Oikopleura dioica
EFX65733  100 RSRLYVGNLGndivEQDLKEYFSAYGEIAEVFLNkEKGFAFVRLDyRSNSEKAKRELdg--kvLKGRTLRVRS 170 common water flea
NP_498295 115 RCRLFVGNLPnevkETELKELFSPHGDIAECYLS-GKGFAFLRLDtRAHAESAKEAIdg--riIHGRQVRVRF 184 nematode
EDO38842    9 RCRLFVGNLIdc-dEEEMKEMFKKYGEVAEVFINkEKGFGFIRLDtRLHAEAAKAGLdm--atRKGRTLRVRF 78  starlet sea anemone
EEC01767  286 RCRLFVGNLApsmtEEEFRKLFSAYGELVEVFLHsQKGFGFIKYEqRQQAEAAKTALdn--vpRDGKYLQVRF 356 black-legged tick
3SDE_B     22 RSRLFVGNLPpditEEEMRKLFEKYGKAGEVFIHkDKGFGFIRLEtRTLAEIAKVELdn--mpLRGKQLRVRF 92  human
5CA5_A     21 RCRLFVGNLPnevkETELKELFSPHGDIAECYLS-GKGFAFLRLDtRAHAESAKEAIdg--riIHGRQVRVRF 90  Caenorhabditis elegans

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